Aliases for UBASH3A Gene
External Ids for UBASH3A Gene
Previous GeneCards Identifiers for UBASH3A Gene
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for UBASH3A Gene
UBASH3A (Ubiquitin Associated And SH3 Domain Containing A) is a Protein Coding gene. Diseases associated with UBASH3A include Hantavirus Hemorrhagic Fever With Renal Syndrome and Dirofilariasis. An important paralog of this gene is UBASH3B.
UniProtKB/Swiss-Prot Summary for UBASH3A Gene
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.