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Aliases for UBALD2 Gene
Aliases for UBALD2 Gene
External Ids for UBALD2 Gene
- HGNC: 28438
- NCBI Entrez Gene: 283991
- Ensembl: ENSG00000185262
- UniProtKB/Swiss-Prot: Q8IYN6
Previous HGNC Symbols for UBALD2 Gene
- FAM100B
Previous GeneCards Identifiers for UBALD2 Gene
- GC17P074262
Summaries for UBALD2 Gene
GeneCards Summary for UBALD2 Gene
UBALD2 (UBA Like Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is UBALD1.
Additional gene information for UBALD2 Gene
- HGNC (28438)
- NCBI Entrez Gene (283991)
- Ensembl (ENSG00000185262)
- UniProtKB/Swiss-Prot (Q8IYN6)
- Open Targets Platform(ENSG00000185262)
- Search for UBALD2 at DataMed
- Search for UBALD2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBALD2 Gene
Genomics for UBALD2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UBALD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBALD2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBALD2
Genomic Locations for UBALD2 Gene
Latest Assembly
- chr17:76,265,348-76,271,298
- (GRCh38/hg38)
- Size:
- 5,951 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:74,261,429-74,267,379
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 5,951 bases
- Orientation:
- Plus strand
- chr17:74,261,283-74,267,375
- (GRCh37/hg19 by Ensembl)
- Size:
- 6,093 bases
- Orientation:
- Plus strand
Genomic View for UBALD2 Gene
Genes around UBALD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
UBALD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBALD2 Gene
Proteins for UBALD2 Gene
-
Protein details for UBALD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYN6-UBAD2_HUMAN
- Recommended name:
- UBA-like domain-containing protein 2
- Protein Accession:
- Q8IYN6
Protein attributes for UBALD2 Gene
- Size:
- 164 amino acids
- Molecular mass:
- 17877 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for UBALD2 Gene
Other Protein References for UBALD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for UBALD2
- Invitrogen Antibodies for UBALD2 (AFLGC-UBALD2)
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for UBALD2
- Origene Custom Protein Services for UBALD2
- Novus Biologicals proteins for UBALD2
Assay products for research
No data available for DME Specific Peptides for UBALD2 Gene
Domains & Families for UBALD2 Gene
Gene Families for UBALD2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for UBALD2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for UBALD2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein FAM100B (F100B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IYN6- Family:
-
- Belongs to the UBALD family.
Function for UBALD2 Gene
Phenotypes From GWAS Catalog for UBALD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for UBALD2 Gene
- GenomeRNAi human phenotypes for UBALD2:
-
- no effect
- Decreased viability
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), decreased viability (cell death)
- Decreased and increased HIV-LTR-beta-galactosidase protein expression
Animal Models for research
-
Taconic Biosciences Mouse Models for UBALD2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBALD2 - Starting at $85 >
- * UBALD2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBALD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBALD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBALD2
miRNA for UBALD2 Gene
- miRTarBase miRNAs that target UBALD2
-
- hsa-miR-4738-5p (MIRT489449)
- mmu-miR-340-5p (MIRT600912)
- hsa-miR-1913 (MIRT738493)
- hsa-miR-324-3p (MIRT741235)
- hsa-miR-361-3p (MIRT741646)
- hsa-miR-4267 (MIRT743523)
- hsa-miR-4313 (MIRT743966)
- hsa-miR-4690-3p (MIRT747065)
- hsa-miR-5685 (MIRT751193)
- hsa-miR-6512-3p (MIRT753238)
- hsa-miR-6720-5p (MIRT753770)
- hsa-miR-6736-3p (MIRT754203)
- hsa-miR-6829-5p (MIRT757118)
- hsa-miR-6849-3p (MIRT757556)
- hsa-miR-766-3p (MIRT759624)
- hsa-miR-1587 (MIRT762920)
- hsa-miR-3620-5p (MIRT766117)
- hsa-miR-378g (MIRT767526)
- hsa-miR-4492 (MIRT769725)
- hsa-miR-4498 (MIRT769759)
- hsa-miR-4656 (MIRT770767)
- hsa-miR-4675 (MIRT770899)
- hsa-miR-4741 (MIRT771885)
- hsa-miR-5001-5p (MIRT772924)
- hsa-miR-762 (MIRT781798)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBALD2
- Browse OriGene Inhibitory RNA Products For UBALD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBALD2
Clone products for research
- Applied Biological Materials (abm): Clones for UBALD2 - Starting at $45 >
- * UBALD2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for UBALD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBALD2
Cell Lines for research
-
Horizon Cell Lines for UBALD2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBALD2 Gene
Localization for UBALD2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| nucleus | 1 |
| mitochondrion | 0 |
| cytosol | 0 |
| golgi apparatus | 0 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UBALD2 Gene
Transcripts for UBALD2 Gene
mRNA/cDNA for UBALD2 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000327490 1446 nts (view in UCSC)
- ENST00000587913 286 nts (view in UCSC)
- ENST00000589240 660 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBALD2 - Starting at $85 >
- * UBALD2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBALD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBALD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBALD2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBALD2
- Browse OriGene Inhibitory RNA Products For UBALD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBALD2
Clone products for research
- Applied Biological Materials (abm): Clones for UBALD2 - Starting at $45 >
- * UBALD2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for UBALD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBALD2
Relevant External Links for UBALD2 Gene
- GeneLoc Exon Structure for
- UBALD2
Expression for UBALD2 Gene
mRNA differential expression in normal tissues according to GTEx for UBALD2 Gene
This gene is overexpressed in Whole Blood (x11.8).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBALD2
SOURCE GeneReport for Unigene cluster for UBALD2 Gene:
Hs.744981Evidence on tissue expression from TISSUES for UBALD2 Gene
- Muscle(2.2)
Primer products for research
-
OriGene qPCR primer pairs for UBALD2
-
OriGene qPCR primer pairs and template standards for UBALD2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBALD2 Gene
Orthologs for UBALD2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UBALD2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | UBALD2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ubald2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ubald2 30 17 31 |
|
OneToMany | |
| Gm7367 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | UBALD2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UBALD2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ubald2 30 |
|
||
| Str.19931 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5480 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ubald2 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for UBALD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for UBALD2 Gene
- ENSEMBL:
- Gene Tree for UBALD2 (if available)
- TreeFam:
- Gene Tree for UBALD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBALD2: view image
Paralogs for UBALD2 Gene
Variants for UBALD2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Gene Damage Index Score:
0.11;
2.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBALD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UBALD2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBALD2 Gene
Disorders for UBALD2 Gene
Additional Disease Information for UBALD2
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for UBALD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBALD2 Gene
Publications for UBALD2 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4
- Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
ExternalLinks
Products for UBALD2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for UBALD2
- Origene Custom Protein Services for UBALD2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBALD2
- Browse OriGene Inhibitory RNA Products For UBALD2
- OriGene qPCR primer pairs for UBALD2
- OriGene qPCR primer pairs and template standards for UBALD2
- OriGene CRISPR knockouts for UBALD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For UBALD2
- Sino Biological Human cDNA Clone for UBALD2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for UBALD2
- Novus Biologicals proteins for UBALD2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for UBALD2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for UBALD2 (AFLGC-UBALD2)
- VectorBuilder Custom and pre-made DNA vectors for UBALD2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for UBALD2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for UBALD2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for UBALD2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for UBALD2
- antibodies-online: Search results for available UBALD2 related products ranked by validation data
- antibodies-online: Search results for available UBALD2 related products ranked by validation data
- antibodies-online: Search results for available UBALD2 related products ranked by validation data
- Horizon Cell Lines for UBALD2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBALD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBALD2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for UBALD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBALD2
Sources for UBALD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB