Aliases for UBA7 Gene
External Ids for UBA7 Gene
Previous HGNC Symbols for UBA7 Gene
Previous GeneCards Identifiers for UBA7 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBA7 Gene
UBA7 (Ubiquitin Like Modifier Activating Enzyme 7) is a Protein Coding gene. Diseases associated with UBA7 include Acute Promyelocytic Leukemia and Hutchinson-Gilford Progeria Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin activating enzyme activity. An important paralog of this gene is UBA1.
UniProtKB/Swiss-Prot for UBA7 Gene
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.