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Aliases for U2SURP Gene

Aliases for U2SURP Gene

  • U2 SnRNP Associated SURP Domain Containing 2 3 5
  • Functional Spliceosome-Associated Protein A 2 3
  • Ser/Arg-Rich Domain Protein, 140 KDa 2 3
  • 140 KDa Ser/Arg-Rich Domain Protein 3 4
  • U2-Associated Protein SR140 3 4
  • SR140 3 4
  • U2 SnRNP-Associated SURP Motif-Containing Protein 3
  • U2 SnRNP-Associated SURP Domain Containing 2
  • U2 Associated SR140 Protein 2
  • U2-Associated SR140 Protein 3
  • KIAA0332 4
  • FSAPa 3

External Ids for U2SURP Gene

Previous GeneCards Identifiers for U2SURP Gene

  • GC03P142720
  • GC03P142683

Summaries for U2SURP Gene

GeneCards Summary for U2SURP Gene

U2SURP (U2 SnRNP Associated SURP Domain Containing) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

Additional gene information for U2SURP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for U2SURP Gene

Genomics for U2SURP Gene

GeneHancer (GH) Regulatory Elements for U2SURP Gene

Promoters and enhancers for U2SURP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I142997 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 568.2 +35.9 35924 6.2 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 U2SURP LOC100289361 XRN1 PBX2P1 ATR ST13P15 PAQR9 PAQR9-AS1 TFDP2 LOC100507389
GH03I142962 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 563.2 -1.2 -1150 2.3 HDGF PKNOX1 ARID4B ZNF2 ZNF48 YY1 GLIS2 SP3 ZHX2 REST U2SURP PAQR9 ATR GC03P142958 PAQR9-AS1
GH03I143118 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 31.5 +156.9 156852 5.5 HDGF PKNOX1 SMAD1 ATF1 SIN3A IRF4 POLR2B GLIS2 ZNF143 RUNX3 CHST2 U2SURP XRN1 ATR PBX2P1 GK5 ENSG00000241679 LOC105374137
GH03I142222 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.7 -740.1 -740097 3.6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 GK5 U2SURP PBX2P1 XRN1 ATR TRPC1 RASA2 TFDP2
GH03I143442 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +479.7 479667 3.4 PKNOX1 ATF1 ARNT BATF RAD21 ZBTB40 EGR1 FOS ATF7 RUNX3 U2SURP ATR XRN1 CHST2 GC03M143367 SLC9A9-AS2 SLC9A9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around U2SURP on UCSC Golden Path with GeneCards custom track

Genomic Locations for U2SURP Gene

Genomic Locations for U2SURP Gene
chr3:142,964,497-143,060,725
(GRCh38/hg38)
Size:
96,229 bases
Orientation:
Plus strand
chr3:142,683,339-142,779,567
(GRCh37/hg19)

Genomic View for U2SURP Gene

Genes around U2SURP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
U2SURP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for U2SURP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2SURP Gene

Proteins for U2SURP Gene

  • Protein details for U2SURP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15042-SR140_HUMAN
    Recommended name:
    U2 snRNP-associated SURP motif-containing protein
    Protein Accession:
    O15042
    Secondary Accessions:
    • A0PJ60
    • Q0D2M1
    • Q2NKQ7
    • Q9BR70

    Protein attributes for U2SURP Gene

    Size:
    1029 amino acids
    Molecular mass:
    118292 Da
    Quaternary structure:
    • Interacts with ERBB4.
    SequenceCaution:
    • Sequence=AAH16323.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI05605.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for U2SURP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2SURP Gene

Post-translational modifications for U2SURP Gene

  • Ubiquitination at posLast=476476 and isoforms=2, 3622

No data available for DME Specific Peptides for U2SURP Gene

Domains & Families for U2SURP Gene

Gene Families for U2SURP Gene

Suggested Antigen Peptide Sequences for U2SURP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15042

UniProtKB/Swiss-Prot:

SR140_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with U2SURP: view

Function for U2SURP Gene

Gene Ontology (GO) - Molecular Function for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22681889
GO:0005515 protein binding IPI 20858735
genes like me logo Genes that share ontologies with U2SURP: view
genes like me logo Genes that share phenotypes with U2SURP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for U2SURP Gene

Localization for U2SURP Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2SURP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for U2SURP gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 20858735
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with U2SURP: view

Pathways & Interactions for U2SURP Gene

genes like me logo Genes that share pathways with U2SURP: view

Pathways by source for U2SURP Gene

Gene Ontology (GO) - Biological Process for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with U2SURP: view

No data available for SIGNOR curated interactions for U2SURP Gene

Drugs & Compounds for U2SURP Gene

No Compound Related Data Available

Transcripts for U2SURP Gene

Unigene Clusters for U2SURP Gene

U2 snRNP-associated SURP domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for U2SURP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:

ExUns: 21b ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for U2SURP Gene

GeneLoc Exon Structure for
U2SURP
ECgene alternative splicing isoforms for
U2SURP

Expression for U2SURP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for U2SURP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for U2SURP Gene

This gene is overexpressed in Lymph node (13.2), Fetal testis (6.4), and Blymphocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for U2SURP Gene



Protein tissue co-expression partners for U2SURP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of U2SURP Gene:

U2SURP

SOURCE GeneReport for Unigene cluster for U2SURP Gene:

Hs.596572

Evidence on tissue expression from TISSUES for U2SURP Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with U2SURP: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for U2SURP Gene

Orthologs for U2SURP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2SURP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2SURP 33 34
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia U2SURP 33 34
  • 95.95 (n)
cow
(Bos Taurus)
Mammalia U2SURP 33 34
  • 95.66 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia U2surp 33
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia U2surp 33 16 34
  • 92.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia U2SURP 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves U2SURP 33 34
  • 84.71 (n)
lizard
(Anolis carolinensis)
Reptilia U2SURP 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia u2surp 33
  • 79.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2668 33
zebrafish
(Danio rerio)
Actinopterygii u2surp 33 34
  • 72.18 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG9346 33 34
  • 55.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005006 33
  • 53.43 (n)
worm
(Caenorhabditis elegans)
Secernentea C07H6.4 33 34
  • 49.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25060 33
  • 50.83 (n)
rice
(Oryza sativa)
Liliopsida Os02g0179900 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
Species where no ortholog for U2SURP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for U2SURP Gene

ENSEMBL:
Gene Tree for U2SURP (if available)
TreeFam:
Gene Tree for U2SURP (if available)

Paralogs for U2SURP Gene

Pseudogenes.org Pseudogenes for U2SURP Gene

genes like me logo Genes that share paralogs with U2SURP: view

No data available for Paralogs for U2SURP Gene

Variants for U2SURP Gene

Sequence variations from dbSNP and Humsavar for U2SURP Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000027194 -- 143,054,358(+) A/T intron_variant
rs1000027376 -- 143,059,570(+) A/T 3_prime_UTR_variant
rs1000028725 -- 143,044,725(+) A/G intron_variant
rs1000055500 -- 143,037,084(+) G/A intron_variant
rs1000058283 -- 143,054,045(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for U2SURP Gene

Variant ID Type Subtype PubMed ID
nsv591921 CNV loss 21841781
nsv513081 CNV loss 21212237
esv3598016 CNV gain 21293372
esv3598015 CNV gain 21293372
esv2759183 CNV gain 17122850
dgv4913n100 CNV gain 25217958

Variation tolerance for U2SURP Gene

Residual Variation Intolerance Score: 4.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for U2SURP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
U2SURP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for U2SURP Gene

Disorders for U2SURP Gene

Additional Disease Information for U2SURP

No disorders were found for U2SURP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for U2SURP Gene

Publications for U2SURP Gene

  1. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PMID: 12234937) Will CL … Lührmann R (The EMBO journal 2002) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  3. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. (PMID: 20858735) Gilmore-Hebert M … Stern DF (Molecular cancer research : MCR 2010) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for U2SURP Gene

Sources for U2SURP Gene

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