Aliases for U2AF1L5 Gene

Aliases for U2AF1L5 Gene

  • U2 Small Nuclear RNA Auxiliary Factor 1 Like 5 2 3 5
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like Protein 5 3 4
  • Splicing Factor U2AF 35 KDa Subunit-Like Protein 3 4
  • Splicing Factor U2AF 35 KDa Subunit 3

External Ids for U2AF1L5 Gene

Summaries for U2AF1L5 Gene

GeneCards Summary for U2AF1L5 Gene

U2AF1L5 (U2 Small Nuclear RNA Auxiliary Factor 1 Like 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. An important paralog of this gene is U2AF1.

UniProtKB/Swiss-Prot Summary for U2AF1L5 Gene

  • Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.

Additional gene information for U2AF1L5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for U2AF1L5 Gene

Genomics for U2AF1L5 Gene

GeneHancer (GH) Regulatory Elements for U2AF1L5 Gene

Promoters and enhancers for U2AF1L5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J006497 Promoter 0.3 Ensembl 500.7 +0.5 483 6 HSALNG0133381 U2AF1L5 piR-52662-003
GH21J006495 Enhancer 0.2 Ensembl 0.7 +4.2 4183 0.2 U2AF1L5 piR-52662-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around U2AF1L5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for U2AF1L5

Genomic Locations for U2AF1L5 Gene

Genomic Locations for U2AF1L5 Gene
chr21:6,484,623-6,499,284
(GRCh38/hg38)
Size:
14,662 bases
Orientation:
Minus strand

Genomic View for U2AF1L5 Gene

Genes around U2AF1L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
U2AF1L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for U2AF1L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2AF1L5 Gene

Proteins for U2AF1L5 Gene

  • Protein details for U2AF1L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN76-U2AF5_HUMAN
    Recommended name:
    Splicing factor U2AF 35 kDa subunit-like protein
    Protein Accession:
    P0DN76

    Protein attributes for U2AF1L5 Gene

    Size:
    240 amino acids
    Molecular mass:
    27872 Da
    Quaternary structure:
    • Interacts (via RS domain) with PHF5A (via N-terminus). Identified in the spliceosome C complex. Heterodimer with U2AF2. Interacts with ZRANB2.

neXtProt entry for U2AF1L5 Gene

Post-translational modifications for U2AF1L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for U2AF1L5 Gene

Domains & Families for U2AF1L5 Gene

Gene Families for U2AF1L5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for U2AF1L5 Gene

Graphical View of Domain Structure for InterPro Entry

P0DN76

UniProtKB/Swiss-Prot:

U2AF5_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with U2AF1L5: view

No data available for Suggested Antigen Peptide Sequences for U2AF1L5 Gene

Function for U2AF1L5 Gene

Molecular function for U2AF1L5 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.

Gene Ontology (GO) - Molecular Function for U2AF1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0030628 pre-mRNA 3'-splice site binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with U2AF1L5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for U2AF1L5 Gene

Localization for U2AF1L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2AF1L5 Gene

Nucleus. Nucleus speckle.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for U2AF1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IBA 21873635
GO:0016607 nuclear speck IEA --
GO:0089701 U2AF IEA,IBA 21873635
genes like me logo Genes that share ontologies with U2AF1L5: view

No data available for Subcellular locations from COMPARTMENTS for U2AF1L5 Gene

Pathways & Interactions for U2AF1L5 Gene

genes like me logo Genes that share pathways with U2AF1L5: view

Pathways by source for U2AF1L5 Gene

2 KEGG pathways for U2AF1L5 Gene

Gene Ontology (GO) - Biological Process for U2AF1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA 21873635
genes like me logo Genes that share ontologies with U2AF1L5: view

No data available for SIGNOR curated interactions for U2AF1L5 Gene

Drugs & Compounds for U2AF1L5 Gene

No Compound Related Data Available

Transcripts for U2AF1L5 Gene

mRNA/cDNA for U2AF1L5 Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for U2AF1L5 Gene

No ASD Table

Relevant External Links for U2AF1L5 Gene

GeneLoc Exon Structure for
U2AF1L5

Expression for U2AF1L5 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for U2AF1L5 Gene

Orthologs for U2AF1L5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2AF1L5 Gene

Organism Taxonomy Gene Similarity Type Details
zebrafish
(Danio rerio)
Actinopterygii u2af1 30
  • 79.28 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons U2AF35B 30
  • 58.38 (n)
rice
(Oryza sativa)
Liliopsida Os05g0564200 30
  • 60.54 (n)
Species where no ortholog for U2AF1L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for U2AF1L5 Gene

ENSEMBL:
Gene Tree for U2AF1L5 (if available)
TreeFam:
Gene Tree for U2AF1L5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for U2AF1L5: view image

Paralogs for U2AF1L5 Gene

Paralogs for U2AF1L5 Gene

genes like me logo Genes that share paralogs with U2AF1L5: view

Variants for U2AF1L5 Gene

Additional dbSNP identifiers (rs#s) for U2AF1L5 Gene

Additional Variant Information for U2AF1L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
U2AF1L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for U2AF1L5 Gene

Disorders for U2AF1L5 Gene

Additional Disease Information for U2AF1L5

No disorders were found for U2AF1L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for U2AF1L5 Gene

Publications for U2AF1L5 Gene

  1. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3 54
  2. CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. (PMID: 28977666) Hoffmeister H … Längst G (Nucleic acids research 2017) 3 54
  3. KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II. (PMID: 26725010) McNamara RP … D'Orso I (Molecular cell 2016) 3 54
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 54
  5. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A … Comb MJ (Molecular & cellular proteomics : MCP 2014) 4 54

Products for U2AF1L5 Gene

Sources for U2AF1L5 Gene