Aliases for U2AF1L4 Gene

Aliases for U2AF1L4 Gene

  • U2 Small Nuclear RNA Auxiliary Factor 1 Like 4 2 3 5
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like Protein 3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like Protein 3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like Protein 4 3 4
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 3 2 3
  • Splicing Factor U2AF 26 KDa Subunit 3 4
  • U2 Auxiliary Factor 26 3 4
  • U2AF1-Like Protein 3 3 4
  • U2AF1-Like 4 3 4
  • U2AF1-RS3 3 4
  • U2AF1L3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 3 3
  • U2AF1L3V1 3
  • U2AF1RS3 3
  • U2af26 3

External Ids for U2AF1L4 Gene

Previous HGNC Symbols for U2AF1L4 Gene

  • U2AF1L3

Previous GeneCards Identifiers for U2AF1L4 Gene

  • GC00U914419
  • GC19M040926
  • GC19M036233
  • GC19M032738
  • GC19M035772
  • GC19M035912
  • GC19M038992
  • GC19M039130
  • GC19M039195
  • GC19M035937
  • GC19M036802
  • GC19M037405
  • GC19M037734
  • GC19M038030
  • GC19M038328
  • GC19M038623
  • GC19M038863

Summaries for U2AF1L4 Gene

GeneCards Summary for U2AF1L4 Gene

U2AF1L4 (U2 Small Nuclear RNA Auxiliary Factor 1 Like 4) is a Protein Coding gene. Diseases associated with U2AF1L4 include Myelophthisic Anemia and Atypical Chronic Myeloid Leukemia. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is U2AF1.

UniProtKB/Swiss-Prot Summary for U2AF1L4 Gene

  • RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).

Additional gene information for U2AF1L4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for U2AF1L4 Gene

Genomics for U2AF1L4 Gene

GeneHancer (GH) Regulatory Elements for U2AF1L4 Gene

Promoters and enhancers for U2AF1L4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around U2AF1L4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for U2AF1L4

Top Transcription factor binding sites by QIAGEN in the U2AF1L4 gene promoter:
  • c-Ets-1
  • COMP1
  • CREB
  • deltaCREB
  • NF-1
  • NF-1/L
  • p53
  • POU2F1
  • POU2F1a
  • ZIC2

Genomic Locations for U2AF1L4 Gene

Genomic Locations for U2AF1L4 Gene
chr19:35,742,464-35,745,445
(GRCh38/hg38)
Size:
2,982 bases
Orientation:
Minus strand
chr19:36,233,365-36,236,346
(GRCh37/hg19)
Size:
2,982 bases
Orientation:
Minus strand

Genomic View for U2AF1L4 Gene

Genes around U2AF1L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
U2AF1L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for U2AF1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2AF1L4 Gene

Proteins for U2AF1L4 Gene

  • Protein details for U2AF1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU68-U2AF4_HUMAN
    Recommended name:
    Splicing factor U2AF 26 kDa subunit
    Protein Accession:
    Q8WU68
    Secondary Accessions:
    • A6NKI8
    • Q56UU3

    Protein attributes for U2AF1L4 Gene

    Size:
    220 amino acids
    Molecular mass:
    25744 Da
    Quaternary structure:
    • Interacts with GFI1, U2AF2 and C1QBP.

    Alternative splice isoforms for U2AF1L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2AF1L4 Gene

Post-translational modifications for U2AF1L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for U2AF1L4 Gene

Domains & Families for U2AF1L4 Gene

Gene Families for U2AF1L4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for U2AF1L4 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Zn-finger, C-x8-C-x5-C-x3-H type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for U2AF1L4 Gene

GenScript: Design optimal peptide antigens:
  • U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 (U2AF4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WU68

UniProtKB/Swiss-Prot:

U2AF4_HUMAN :
  • The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
  • Belongs to the splicing factor SR family.
Domain:
  • The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
  • The region 162-220 is essential for the nuclear import of the protein in spite of the absence of a nuclear localization signal (NLS). This region is essential for the interaction with C1QBP, interaction which is required for the nuclear translocation. This region may be involved in the localization in nuclear dot-like structures and it also confers the ability of nucleo-cytoplasmic shuttling.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with U2AF1L4: view

Function for U2AF1L4 Gene

Molecular function for U2AF1L4 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).

Phenotypes From GWAS Catalog for U2AF1L4 Gene

Gene Ontology (GO) - Molecular Function for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0030628 pre-mRNA 3'-splice site binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view
genes like me logo Genes that share phenotypes with U2AF1L4: view

Animal Model Products

CRISPR Products

miRNA for U2AF1L4 Gene

miRTarBase miRNAs that target U2AF1L4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for U2AF1L4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for U2AF1L4 Gene

Localization for U2AF1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2AF1L4 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. {ECO:0000250 UniProtKB:Q8BGJ9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for U2AF1L4 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view

Pathways & Interactions for U2AF1L4 Gene

genes like me logo Genes that share pathways with U2AF1L4: view

Pathways by source for U2AF1L4 Gene

Gene Ontology (GO) - Biological Process for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view

No data available for SIGNOR curated interactions for U2AF1L4 Gene

Drugs & Compounds for U2AF1L4 Gene

No Compound Related Data Available

Transcripts for U2AF1L4 Gene

mRNA/cDNA for U2AF1L4 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for U2AF1L4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for U2AF1L4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9: - -
SP10: - - -
SP11: - - - -
SP12: -
SP13: - -
SP14: -
SP15:

ExUns: 11c · 11d · 11e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for U2AF1L4 Gene

GeneLoc Exon Structure for
U2AF1L4

Expression for U2AF1L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for U2AF1L4 Gene

Protein differential expression in normal tissues from HIPED for U2AF1L4 Gene

This gene is overexpressed in Urine (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for U2AF1L4 Gene



Protein tissue co-expression partners for U2AF1L4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for U2AF1L4

SOURCE GeneReport for Unigene cluster for U2AF1L4 Gene:

Hs.351558

mRNA Expression by UniProt/SwissProt for U2AF1L4 Gene:

Q8WU68-U2AF4_HUMAN
Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for U2AF1L4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with U2AF1L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for U2AF1L4 Gene

Orthologs for U2AF1L4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2AF1L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2AF1L4 30
  • 98.71 (n)
-- 31
  • 51 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia U2af1l4 31
  • 50 (a)
OneToMany
cow
(Bos Taurus)
Mammalia U2AF1L4 31
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta U2af38 31
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uaf-2 31
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12075 30
corn
(Zea mays)
Liliopsida Zm.4357 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9845 31
  • 45 (a)
OneToMany
Species where no ortholog for U2AF1L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for U2AF1L4 Gene

ENSEMBL:
Gene Tree for U2AF1L4 (if available)
TreeFam:
Gene Tree for U2AF1L4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for U2AF1L4: view image

Paralogs for U2AF1L4 Gene

Paralogs for U2AF1L4 Gene

(3) SIMAP similar genes for U2AF1L4 Gene using alignment to 9 proteins:

  • U2AF4_HUMAN
  • K7EJH3_HUMAN
  • K7EJM7_HUMAN
  • K7EPL9_HUMAN
  • M0QYK5_HUMAN
  • M0R1E1_HUMAN
  • S4R353_HUMAN
  • S4R3L8_HUMAN
  • S4R443_HUMAN

Pseudogenes.org Pseudogenes for U2AF1L4 Gene

genes like me logo Genes that share paralogs with U2AF1L4: view

Variants for U2AF1L4 Gene

Additional dbSNP identifiers (rs#s) for U2AF1L4 Gene

Structural Variations from Database of Genomic Variants (DGV) for U2AF1L4 Gene

Variant ID Type Subtype PubMed ID
nsv515536 CNV loss 19592680
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781

Variation tolerance for U2AF1L4 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for U2AF1L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
U2AF1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for U2AF1L4 Gene

Disorders for U2AF1L4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for U2AF1L4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myelophthisic anemia
  • anemia leukoerythroblastic
atypical chronic myeloid leukemia
  • acml
myelodysplastic/myeloproliferative neoplasm
  • myelodysplastic myeloproliferative cancer
chronic leukemia
  • cll
bone marrow cancer
  • bone marrow neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for U2AF1L4

genes like me logo Genes that share disorders with U2AF1L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for U2AF1L4 Gene

Publications for U2AF1L4 Gene

  1. Characterization of U2AF(6), a splicing factor related to U2AF(35). (PMID: 11739736) Shepard J … Graveley BR (Molecular and cellular biology 2002) 2 3 54
  2. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. (PMID: 8586425) Kitagawa K … Murata A (Genomics 1995) 2 3 54
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3 54

Products for U2AF1L4 Gene

Sources for U2AF1L4 Gene