TRMT61A Gene (Protein Coding)

TRNA Methyltransferase 61A

GC14P103529
GIFtS:
32
See more...

Aliases for TRMT61A Gene

Aliases for TRMT61A Gene

  • TRNA Methyltransferase 61A 2 3 5
  • MRNA Methyladenosine-N(1)-Methyltransferase Catalytic Subunit TRMT61A 3 4
  • TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A 3 4
  • TRNA(M1A58)-Methyltransferase Subunit TRMT61A 3 4
  • TRNA(M1A58)MTase Subunit TRMT61A 3 4
  • C14orf172 3 4
  • Gcd14p 2 3
  • HTRM61 2 3
  • GCD14 2 3
  • TRM61 3 4
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A 3
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61 3
  • TRNA Methyltransferase 61 Homolog A (S. Cerevisiae) 2
  • TRNA(M1A58)-Methyltransferase Subunit TRM61 3
  • Chromosome 14 Open Reading Frame 172 2
  • TRNA Methyltransferase 61 Homolog A 3
  • TRNA(M1A58)MTase Subunit TRM61 3
  • EC 2.1.1.220 4
  • EC 2.1.1.36 51
  • EC 2.1.1.- 4
  • FLJ40452 2
  • TRMT61A 5

External Ids for TRMT61A Gene

Previous HGNC Symbols for TRMT61A Gene

  • C14orf172

Previous GeneCards Identifiers for TRMT61A Gene

  • GC14P103067
  • GC14P103995
  • GC14P084173

Summaries for TRMT61A Gene

GeneCards Summary for TRMT61A Gene

TRMT61A (TRNA Methyltransferase 61A) is a Protein Coding gene. Diseases associated with TRMT61A include Combined Oxidative Phosphorylation Deficiency 30 and Thiamine-Responsive Megaloblastic Anemia Syndrome. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity. An important paralog of this gene is TRMT61B.

UniProtKB/Swiss-Prot Summary for TRMT61A Gene

  • Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).

Additional gene information for TRMT61A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRMT61A Gene

Genomics for TRMT61A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TRMT61A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRMT61A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRMT61A

Top Transcription factor binding sites by QIAGEN in the TRMT61A gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • Max1
  • SRY
  • USF-1
  • USF-1:USF-2
  • USF1

Genomic Locations for TRMT61A Gene

Genomic Locations for TRMT61A Gene
chr14:103,529,196-103,537,073
(GRCh38/hg38)
Size:
7,878 bases
Orientation:
Plus strand
chr14:103,995,509-104,003,410
(GRCh37/hg19)
Size:
7,902 bases
Orientation:
Plus strand

Genomic View for TRMT61A Gene

Genes around TRMT61A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT61A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT61A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRMT61A Gene

Proteins for TRMT61A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TRMT61A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FX7-TRM61_HUMAN
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Protein Accession:
    Q96FX7
    Secondary Accessions:
    • A6NN78
    • Q8N7Q9

    Protein attributes for TRMT61A Gene

    Size:
    289 amino acids
    Molecular mass:
    31382 Da
    Quaternary structure:
    • Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.
    SequenceCaution:
    • Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRMT61A Gene

neXtProt entry for TRMT61A Gene

Protein Expression for TRMT61A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for TRMT61A Gene

Q96FX7:
  • GHTGYLTFA
  • PTPELWT
  • LPHRTQI

Post-translational modifications for TRMT61A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT61A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for TRMT61A

Domains & Families for TRMT61A Gene

Gene Families for TRMT61A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRMT61A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRMT61A Gene

GenScript: Design optimal peptide antigens:
  • TRMT61A protein (Q96B39_HUMAN)
  • tRNA(m1A58)-methyltransferase subunit TRMT61A (TRM61_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FX7

UniProtKB/Swiss-Prot:

TRM61_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
genes like me logo Genes that share domains with TRMT61A: view

Function for TRMT61A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TRMT61A Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43152, Rhea:RHEA-COMP:10365, Rhea:RHEA-COMP:10366, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.220; Evidence={ECO:0000255|PROSITE-ProRule:PRU00952, ECO:0000269|PubMed:16043508};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=adenosine in mRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55392, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; Evidence={ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537};.

Enzyme Numbers (IUBMB) for TRMT61A Gene

Phenotypes From GWAS Catalog for TRMT61A Gene

Gene Ontology (GO) - Molecular Function for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16043508
GO:0008168 methyltransferase activity IEA --
GO:0016429 tRNA (adenine-N1-)-methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0061953 mRNA (adenine-N1-)-methyltransferase activity IDA 29072297
genes like me logo Genes that share ontologies with TRMT61A: view
genes like me logo Genes that share phenotypes with TRMT61A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRMT61A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT61A Gene

Localization for TRMT61A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT61A Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT61A gene
Compartment Confidence
nucleus 4
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0031515 tRNA (m1A) methyltransferase complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with TRMT61A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRMT61A Gene

Pathways & Interactions for TRMT61A Gene

PathCards logo

SuperPathways for TRMT61A Gene

genes like me logo Genes that share pathways with TRMT61A: view

Pathways by source for TRMT61A Gene

Gene Ontology (GO) - Biological Process for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA,IBA 21873635
GO:0032259 methylation IEA --
GO:0080009 mRNA methylation IDA 29072297
genes like me logo Genes that share ontologies with TRMT61A: view

No data available for SIGNOR curated interactions for TRMT61A Gene

Drugs & Compounds for TRMT61A Gene

Products:

  1. Drug

(1) Drugs for TRMT61A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for TRMT61A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
 485-80-3
genes like me logo Genes that share compounds with TRMT61A: view

Transcripts for TRMT61A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TRMT61A Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRMT61A

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TRMT61A Gene

GeneLoc Exon Structure for
TRMT61A

Expression for TRMT61A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRMT61A Gene

mRNA expression in normal human tissues for TRMT61A Gene
mRNA expression by BioGPS for TRMT61A GenemRNA expression by GTEx for TRMT61A Gene

Protein differential expression in normal tissues from HIPED for TRMT61A Gene

This gene is overexpressed in Lung (30.3) and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRMT61A Gene



Protein tissue co-expression partners for TRMT61A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRMT61A

SOURCE GeneReport for Unigene cluster for TRMT61A Gene:

Hs.525610
genes like me logo Genes that share expression patterns with TRMT61A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT61A Gene

Orthologs for TRMT61A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT61A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TRMT61A 30 31
  • 99.08 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TRMT61A 30 31
  • 90.76 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TRMT61A 30 31
  • 89.04 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Trmt61a 30
  • 86.85 (n)
Mouse
(Mus musculus)
 Mammalia Trmt61a 30 17 31
  • 85.93 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TRMT61A 31
  • 67 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TRMT61A 31
  • 52 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TRMT61A 30 31
  • 67.83 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TRMT61A 31
  • 67 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia trmt61a 30
  • 65.16 (n)
Str.17346 30
African clawed frog
(Xenopus laevis)
 Amphibia MGC53312 30
Zebrafish
(Danio rerio)
 Actinopterygii trmt61a 30 31
  • 65.73 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG14544 30 31
  • 55.17 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003966 30
  • 54.78 (n)
Worm
(Caenorhabditis elegans)
 Secernentea CELE_W02A11.1 30
  • 53.93 (n)
W02A11.1 31
  • 42 (a)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AFL214C 30
  • 52.71 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E15225g 30
  • 48.72 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GCD14 30 31
  • 46.95 (n)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G14600 30
  • 49.82 (n)
Rice
(Oryza sativa)
 Liliopsida Os04g0326300 30
  • 55.02 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 51 (a)
 OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes cpd1 30
  • 45.69 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.8067 30
Species where no ortholog for TRMT61A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRMT61A Gene

ENSEMBL:
Gene Tree for TRMT61A (if available)
TreeFam:
Gene Tree for TRMT61A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRMT61A: view image

Paralogs for TRMT61A Gene

Paralogs for TRMT61A Gene

genes like me logo Genes that share paralogs with TRMT61A: view

Variants for TRMT61A Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRMT61A Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
VAR_026053 - p.Val66Ala

Additional dbSNP identifiers (rs#s) for TRMT61A Gene

Structural Variations from Database of Genomic Variants (DGV) for TRMT61A Gene

Variant ID Type Subtype PubMed ID
esv3635599 CNV gain 21293372
nsv1044967 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv478428 CNV novel sequence insertion 20440878
nsv566020 CNV loss 21841781
nsv566021 CNV loss 21841781
nsv827068 CNV loss 20364138
nsv832883 CNV loss 17160897
nsv9170 CNV gain 18304495
nsv952259 CNV deletion 24416366

Variation tolerance for TRMT61A Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRMT61A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT61A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61A Gene

Disorders for TRMT61A Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRMT61A Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRMT61A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRMT61A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRMT61A Gene

Publications for TRMT61A Gene

  1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S … Anderson JT (RNA (New York, N.Y.) 2005) 2 3 4
  2. Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. (PMID: 29107537) Li X … Yi C (Molecular cell 2017) 3 4
  3. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. (PMID: 29072297) Safra M … Schwartz S (Nature 2017) 3 4
  4. Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. (PMID: 26470919) Finer-Moore J … Stroud RM (Journal of molecular biology 2015) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

ExternalLinks

View latest publications for TRMT61A gene in Mastermind

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