Aliases for TYW5 Gene
External Ids for TYW5 Gene
Previous HGNC Symbols for TYW5 Gene
Previous GeneCards Identifiers for TYW5 Gene
GeneCards Summary for TYW5 Gene
TYW5 (TRNA-YW Synthesizing Protein 5) is a Protein Coding gene. Diseases associated with TYW5 include Mixed Sleep Apnea. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and tRNA binding. An important paralog of this gene is HSPBAP1.
UniProtKB/Swiss-Prot Summary for TYW5 Gene
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.