Aliases for TYW5 Gene

Aliases for TYW5 Gene

  • TRNA-YW Synthesizing Protein 5 2 3 5
  • TRNA(Phe) (7-(3-Amino-3-Carboxypropyl)Wyosine(37)-C(2))-Hydroxylase 3 4
  • TRNA Wybutosine-Synthesizing Protein 5 3 4
  • C2orf60 3 4
  • HTYW5 3 4
  • JmjC Domain-Containing Protein C2orf60 3
  • Chromosome 2 Open Reading Frame 60 2
  • TRNA YW-Synthesizing Enzyme 5 3
  • EC 1.14.11.42 4

External Ids for TYW5 Gene

Previous HGNC Symbols for TYW5 Gene

  • C2orf60

Previous GeneCards Identifiers for TYW5 Gene

  • GC02M200794

Summaries for TYW5 Gene

GeneCards Summary for TYW5 Gene

TYW5 (TRNA-YW Synthesizing Protein 5) is a Protein Coding gene. Diseases associated with TYW5 include Mixed Sleep Apnea. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and tRNA binding. An important paralog of this gene is HSPBAP1.

UniProtKB/Swiss-Prot Summary for TYW5 Gene

  • tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.

Additional gene information for TYW5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TYW5 Gene

Genomics for TYW5 Gene

GeneHancer (GH) Regulatory Elements for TYW5 Gene

Promoters and enhancers for TYW5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TYW5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TYW5

Genomic Locations for TYW5 Gene

Genomic Locations for TYW5 Gene
chr2:199,928,911-199,955,736
(GRCh38/hg38)
Size:
26,826 bases
Orientation:
Minus strand
chr2:200,793,634-200,820,459
(GRCh37/hg19)
Size:
26,826 bases
Orientation:
Minus strand

Genomic View for TYW5 Gene

Genes around TYW5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYW5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYW5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYW5 Gene

Proteins for TYW5 Gene

  • Protein details for TYW5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUC4-TYW5_HUMAN
    Recommended name:
    tRNA wybutosine-synthesizing protein 5
    Protein Accession:
    A2RUC4
    Secondary Accessions:
    • B2RNE3
    • Q8N1R2

    Protein attributes for TYW5 Gene

    Size:
    315 amino acids
    Molecular mass:
    36548 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH63502.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TYW5 Gene

    Alternative splice isoforms for TYW5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TYW5 Gene

Post-translational modifications for TYW5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TYW5 Gene

No data available for DME Specific Peptides for TYW5 Gene

Domains & Families for TYW5 Gene

Gene Families for TYW5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TYW5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TYW5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78342 (A8KAJ9_HUMAN)
  • tRNA wybutosine-synthesizing protein 5 (TYW5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A2RUC4

UniProtKB/Swiss-Prot:

TYW5_HUMAN :
  • Belongs to the TYW5 family.
Family:
  • Belongs to the TYW5 family.
genes like me logo Genes that share domains with TYW5: view

Function for TYW5 Gene

Molecular function for TYW5 Gene

UniProtKB/Swiss-Prot Function:
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate; Xref=Rhea:RHEA:37899, Rhea:RHEA-COMP:10379, Rhea:RHEA-COMP:11848, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:73543, ChEBI:CHEBI:73603; EC=1.14.11.42;.

Enzyme Numbers (IUBMB) for TYW5 Gene

Phenotypes From GWAS Catalog for TYW5 Gene

Gene Ontology (GO) - Molecular Function for TYW5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 20972222
GO:0005506 iron ion binding IDA 20972222
GO:0016491 oxidoreductase activity IEA --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA,IBA 20739293
GO:0042803 protein homodimerization activity IDA 20972222
genes like me logo Genes that share ontologies with TYW5: view
genes like me logo Genes that share phenotypes with TYW5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYW5

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TYW5 Gene

Localization for TYW5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYW5 gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TYW5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS --
genes like me logo Genes that share ontologies with TYW5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TYW5 Gene

Pathways & Interactions for TYW5 Gene

genes like me logo Genes that share pathways with TYW5: view

UniProtKB/Swiss-Prot A2RUC4-TYW5_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.

Gene Ontology (GO) - Biological Process for TYW5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
GO:0031591 wybutosine biosynthetic process IBA,IDA 20739293
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TYW5: view

No data available for SIGNOR curated interactions for TYW5 Gene

Drugs & Compounds for TYW5 Gene

No Compound Related Data Available

Transcripts for TYW5 Gene

mRNA/cDNA for TYW5 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYW5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TYW5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for TYW5 Gene

GeneLoc Exon Structure for
TYW5

Expression for TYW5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TYW5 Gene

Protein differential expression in normal tissues from HIPED for TYW5 Gene

This gene is overexpressed in Heart (33.7), Skin (11.0), and Retina (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TYW5 Gene



Protein tissue co-expression partners for TYW5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TYW5

SOURCE GeneReport for Unigene cluster for TYW5 Gene:

Hs.204619

Evidence on tissue expression from TISSUES for TYW5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TYW5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TYW5 Gene

Orthologs for TYW5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TYW5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYW5 31 30
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TYW5 31 30
  • 92.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TYW5 31 30
  • 90.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tyw5 17 31 30
  • 86.88 (n)
rat
(Rattus norvegicus)
Mammalia Tyw5 30
  • 85.82 (n)
oppossum
(Monodelphis domestica)
Mammalia TYW5 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TYW5 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TYW5 31 30
  • 77.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYW5 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tyw5 30
  • 70.73 (n)
zebrafish
(Danio rerio)
Actinopterygii tyw5 31 30
  • 62.68 (n)
OneToOne
Dr.14896 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 59 (a)
OneToOne
Species where no ortholog for TYW5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYW5 Gene

ENSEMBL:
Gene Tree for TYW5 (if available)
TreeFam:
Gene Tree for TYW5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TYW5: view image

Paralogs for TYW5 Gene

Paralogs for TYW5 Gene

Pseudogenes.org Pseudogenes for TYW5 Gene

genes like me logo Genes that share paralogs with TYW5: view

Variants for TYW5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TYW5 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs10497844 - p.Ser50Gly

Additional dbSNP identifiers (rs#s) for TYW5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TYW5 Gene

Variant ID Type Subtype PubMed ID
nsv834510 CNV loss 17160897

Variation tolerance for TYW5 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TYW5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TYW5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYW5 Gene

Disorders for TYW5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TYW5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed sleep apnea
  • complex sleep apnea
- elite association - COSMIC cancer census association via MalaCards
Search TYW5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TYW5

genes like me logo Genes that share disorders with TYW5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TYW5 Gene

Publications for TYW5 Gene

  1. Expanding role of the jumonji C domain as an RNA hydroxylase. (PMID: 20739293) Noma A … Suzuki T (The Journal of biological chemistry 2010) 2 3 4 54
  2. Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. (PMID: 20972222) Kato M … Nureki O (Nucleic acids research 2011) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 54

Products for TYW5 Gene

Sources for TYW5 Gene