Aliases for TYW1 Gene
- TRNA-YW Synthesizing Protein 1 Homolog 2 3 5
- Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 1 3 4
- S-Adenosyl-L-Methionine-Dependent TRNA 4-Demethylwyosine Synthase TYW1 3 4
- Radical S-Adenosyl Methionine And Flavodoxin Domains 1 2 3
- TRNA Wybutosine-Synthesizing Protein 1 Homolog 3 4
- RSAFD1 3 4
- S-Adenosyl-L-Methionine-Dependent TRNA 4-Demethylwyosine Synthase 3
External Ids for TYW1 Gene
Previous HGNC Symbols for TYW1 Gene
Previous GeneCards Identifiers for TYW1 Gene
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for TYW1 Gene
TYW1 (TRNA-YW Synthesizing Protein 1 Homolog) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 4 iron, 4 sulfur cluster binding. An important paralog of this gene is TYW1B.
UniProtKB/Swiss-Prot Summary for TYW1 Gene
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).