This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009] See more...

Aliases for TYRP1 Gene

Aliases for TYRP1 Gene

  • Tyrosinase Related Protein 1 2 3 5
  • TRP 2 3 4
  • 5,6-Dihydroxyindole-2-Carboxylic Acid Oxidase 3 4
  • Melanoma Antigen Gp75 3 4
  • Glycoprotein 75 3 4
  • DHICA Oxidase 3 4
  • Catalase B 3 4
  • B-PROTEIN 2 3
  • CAS2 3 4
  • CATB 2 3
  • GP75 2 3
  • OCA3 2 3
  • TRP1 3 4
  • TYRP 3 4
  • Tyrosinase-Related Protein 1 4
  • EC 1.14.18.1 50
  • EC 1.14.18.- 4
  • EC 1.14.18 50
  • TYRP1 5
  • TYRRP 4
  • TRP-1 4

External Ids for TYRP1 Gene

Previous HGNC Symbols for TYRP1 Gene

  • TYRP
  • CAS2

Previous GeneCards Identifiers for TYRP1 Gene

  • GC09P012859
  • GC09P012674

Summaries for TYRP1 Gene

Entrez Gene Summary for TYRP1 Gene

  • This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

GeneCards Summary for TYRP1 Gene

TYRP1 (Tyrosinase Related Protein 1) is a Protein Coding gene. Diseases associated with TYRP1 include Albinism, Oculocutaneous, Type Iii and Skin/Hair/Eye Pigmentation, Variation In, 11. Among its related pathways are Metabolism and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity. An important paralog of this gene is DCT.

UniProtKB/Swiss-Prot Summary for TYRP1 Gene

  • Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).

Gene Wiki entry for TYRP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TYRP1 Gene

Genomics for TYRP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TYRP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J012684 Enhancer 0.5 Ensembl ENCODE 250.7 -0.3 -338 1.4 MAFK MAFF TYRP1 HSALNG0070009 LURAP1L-AS1
GH09J012693 Promoter 0.3 EPDnew 250.4 +8.0 7994 0.1 TYRP1 lnc-LURAP1L-2 LURAP1L LURAP1L-AS1
GH09J012694 Promoter 0.3 EPDnew 250.4 +8.5 8477 0.1 TYRP1 lnc-LURAP1L-2 LURAP1L LURAP1L-AS1
GH09J012333 Promoter 0.3 EPDnew 250 -351.5 -351472 0.1 piR-45012-516 TYRP1 piR-31534-682
GH09J012697 Promoter/Enhancer 1 Ensembl ENCODE 10.4 +11.6 11562 3.2 FEZF1 ZNF843 BCL11B PRDM6 ZBTB48 NFE2L2 NFIB PRDM4 MAFK GATA2 TYRP1 LURAP1L lnc-LURAP1L-2 LURAP1L-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TYRP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TYRP1

Top Transcription factor binding sites by QIAGEN in the TYRP1 gene promoter:
  • ATF-2
  • STAT3
  • TBP
  • TFIID

Genomic Locations for TYRP1 Gene

Latest Assembly
chr9:12,685,439-12,710,285
(GRCh38/hg38)
Size:
24,847 bases
Orientation:
Plus strand

Previous Assembly
chr9:12,693,385-12,710,285
(GRCh37/hg19 by Entrez Gene)
Size:
16,901 bases
Orientation:
Plus strand

chr9:12,685,439-12,710,290
(GRCh37/hg19 by Ensembl)
Size:
24,852 bases
Orientation:
Plus strand

Genomic View for TYRP1 Gene

Genes around TYRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYRP1 Gene

Proteins for TYRP1 Gene

  • Protein details for TYRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17643-TYRP1_HUMAN
    Recommended name:
    5,6-dihydroxyindole-2-carboxylic acid oxidase
    Protein Accession:
    P17643
    Secondary Accessions:
    • P78468
    • P78469
    • Q13721
    • Q15679

    Protein attributes for TYRP1 Gene

    Size:
    537 amino acids
    Molecular mass:
    60724 Da
    Cofactor:
    Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for TYRP1 Gene

neXtProt entry for TYRP1 Gene

Selected DME Specific Peptides for TYRP1 Gene

P17643:
  • NSVFSQWRV
  • VRSLHNLAHLFLNGTGGQTH
  • QFENISIYN
  • SFRNTVEGYS
  • NAPIGHN
  • FVWTHYYS
  • SPNDPIFVLLHTFTDAVFDEWLRR
  • NDPIFVL

Post-translational modifications for TYRP1 Gene

  • Glycosylated.
  • Glycosylation at Asn96, Asn104, Asn181, Asn304, Asn350, and Asn385
  • Modification sites at PhosphoSitePlus

Other Protein References for TYRP1 Gene

Domains & Families for TYRP1 Gene

Gene Families for TYRP1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TYRP1 Gene

InterPro:
Blocks:
  • Tyrosinase copper-binding domain signature

Suggested Antigen Peptide Sequences for TYRP1 Gene

GenScript: Design optimal peptide antigens:
  • TYRP1 protein (Q6LES1_HUMAN)
  • Tyrosinase-related protein 1, isoform CRA_d (Q8WX62_HUMAN)
  • Tyrosinase-related protein 1 (TYRP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17643

UniProtKB/Swiss-Prot:

TYRP1_HUMAN :
  • Belongs to the tyrosinase family.
Family:
  • Belongs to the tyrosinase family.
genes like me logo Genes that share domains with TYRP1: view

Function for TYRP1 Gene

Molecular function for TYRP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
The activity depends critically on the nature of the bound metal ion. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the presence of bound Cu(2+) ions, but lacks activity in the presence of bound Zn(2+) ions.
GENATLAS Biochemistry:
tyrosinase-related protein 1,involved in melanogenesis

Enzyme Numbers (IUBMB) for TYRP1 Gene

Phenotypes From GWAS Catalog for TYRP1 Gene

Gene Ontology (GO) - Molecular Function for TYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0004503 monophenol monooxygenase activity IDA 21291857
GO:0005515 protein binding IPI 11441007
GO:0016491 oxidoreductase activity IEA,TAS --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TYRP1: view
genes like me logo Genes that share phenotypes with TYRP1: view

Human Phenotype Ontology for TYRP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYRP1

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TYRP1 Gene

Localization for TYRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TYRP1 Gene

Melanosome membrane. Single-pass type I membrane protein. Melanosome. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250 UniProtKB:P07147}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYRP1 gene
Compartment Confidence
endosome 5
plasma membrane 3
extracellular 3
lysosome 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21291857
GO:0010008 endosome membrane IDA 19841138
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030669 clathrin-coated endocytic vesicle membrane IDA 19841138
genes like me logo Genes that share ontologies with TYRP1: view

Pathways & Interactions for TYRP1 Gene

genes like me logo Genes that share pathways with TYRP1: view

Pathways by source for TYRP1 Gene

1 BioSystems pathway for TYRP1 Gene
3 KEGG pathways for TYRP1 Gene

UniProtKB/Swiss-Prot P17643-TYRP1_HUMAN

  • Pathway: Pigment biosynthesis; melanin biosynthesis.

SIGNOR curated interactions for TYRP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006582 melanin metabolic process IEA --
GO:0030318 melanocyte differentiation IEA,IBA 21873635
GO:0032438 melanosome organization IEA,IBA 21873635
GO:0042438 melanin biosynthetic process IEA,TAS --
GO:0043438 acetoacetic acid metabolic process IEA --
genes like me logo Genes that share ontologies with TYRP1: view

Drugs & Compounds for TYRP1 Gene

(22) Drugs for TYRP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 276

(17) Additional Compounds for TYRP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydroxyindole-2-carboxylic acid
  • 5,6-DHICA
  • 5,6-Dihydroxy-2-indolecarboxylic acid
  • 5,6-Dihydroxy-2-indolylcarboxylic acid
  • 5,6-Dihydroxyindole-2-carboxylate
  • DHI2c
4790-08-3
Melanin
  • Allomelanins
  • Melanins
  • Phaeomelanins
8049-97-6
genes like me logo Genes that share compounds with TYRP1: view

Transcripts for TYRP1 Gene

mRNA/cDNA for TYRP1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYRP1

Alternative Splicing Database (ASD) splice patterns (SP) for TYRP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for TYRP1 Gene

GeneLoc Exon Structure for
TYRP1

Expression for TYRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TYRP1 Gene

mRNA differential expression in normal tissues according to GTEx for TYRP1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.3), Skin - Sun Exposed (Lower leg) (x13.8), Heart - Left Ventricle (x10.1), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for TYRP1 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TYRP1 Gene



Protein tissue co-expression partners for TYRP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TYRP1

SOURCE GeneReport for Unigene cluster for TYRP1 Gene:

Hs.270279

mRNA Expression by UniProt/SwissProt for TYRP1 Gene:

P17643-TYRP1_HUMAN
Tissue specificity: Pigment cells.

Evidence on tissue expression from TISSUES for TYRP1 Gene

  • Skin(4.7)
  • Blood(4.5)
  • Liver(4.4)
  • Eye(4.1)
  • Heart(2.7)
  • Muscle(2.7)
  • Nervous system(2.4)
  • Kidney(2.3)
  • Bone marrow(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TYRP1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • cranial nerve
  • eye
  • head
General:
  • hair
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with TYRP1: view

Primer products for research

Orthologs for TYRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TYRP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TYRP1 29 30
  • 99.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TYRP1 29 30
  • 89.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TYRP1 29 30
  • 88.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tyrp1 29 16 30
  • 85.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tyrp1 29
  • 85.04 (n)
Oppossum
(Monodelphis domestica)
Mammalia TYRP1 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TYRP1 30
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TYRP1 29 30
  • 73.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TYRP1 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tyrp1 29
  • 68.18 (n)
Str.13722 29
African clawed frog
(Xenopus laevis)
Amphibia tyrp1-prov 29
Zebrafish
(Danio rerio)
Actinopterygii tyrp1b 29 30
  • 65.18 (n)
OneToMany
tyrp1a 30
  • 60 (a)
OneToMany
Species where no ortholog for TYRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TYRP1 Gene

ENSEMBL:
Gene Tree for TYRP1 (if available)
TreeFam:
Gene Tree for TYRP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TYRP1: view image
Alliance of Genome Resources:
Additional Orthologs for TYRP1

Paralogs for TYRP1 Gene

Paralogs for TYRP1 Gene

(3) SIMAP similar genes for TYRP1 Gene using alignment to 5 proteins:

  • TYRP1_HUMAN
  • C9JZ52_HUMAN
  • E7EQI3_HUMAN
  • Q5W0M5_HUMAN
  • Q6LES1_HUMAN
genes like me logo Genes that share paralogs with TYRP1: view

Variants for TYRP1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TYRP1 Gene

TYRP1_HUMAN-P17643
Genetic variants in TYRP1 define the skin/hair/eye pigmentation variation locus 11 (SHEP11) [MIM:612271] and are responsible for variability in hair color linked to chromosome 9p23 in Melanesians. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TYRP1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
1025066 Uncertain Significance: not provided 12,709,180(+) T/TAACA
NM_000550.3(TYRP1):c.*1_*4dup (p.Ter538=)
NO_SEQUENCE_ALTERATION
1028344 Pathogenic: Oculocutaneous albinism type 3 12,708,127(+) T/A
NM_000550.3(TYRP1):c.1392T>A (p.Tyr464Ter)
NONSENSE
1038810 Uncertain Significance: not provided 12,702,308(+) AA/TC
NM_000550.3(TYRP1):c.951_952delinsTC (p.Asn318His)
MISSENSE
1045070 Uncertain Significance: not provided 12,694,160(+) G/A
NM_000550.3(TYRP1):c.164G>A (p.Arg55His)
MISSENSE
77560 Uncertain Significance: Oculocutaneous albinism type 3 12,698,528(+) G/A
NM_000550.3(TYRP1):c.786G>A (p.Thr262=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TYRP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TYRP1 Gene

Variant ID Type Subtype PubMed ID
dgv12568n54 CNV loss 21841781
esv2422212 CNV duplication 17116639
esv2759671 CNV loss 17122850
esv3619718 CNV gain 21293372
esv3891612 CNV gain 25118596
nsv1016570 CNV loss 25217958
nsv1021844 CNV gain 25217958
nsv613613 CNV loss 21841781
nsv831513 CNV gain 17160897

Variation tolerance for TYRP1 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TYRP1 Gene

Human Gene Mutation Database (HGMD)
TYRP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TYRP1
Leiden Open Variation Database (LOVD)
TYRP1

SNP Genotyping and Copy Number Assays for research

Disorders for TYRP1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for TYRP1 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search TYRP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TYRP1_HUMAN
  • Albinism, oculocutaneous, 3 (OCA3) [MIM:203290]: An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. {ECO:0000269 PubMed:16704458, ECO:0000269 PubMed:23504663}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for TYRP1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TYRP1: view

No data available for Genatlas for TYRP1 Gene

Publications for TYRP1 Gene

  1. Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma. (PMID: 19710684) Duffy DL … Montgomery GW (The Journal of investigative dermatology 2010) 3 22 40
  2. A comprehensive analysis reveals mutational spectra and common alleles in Chinese patients with oculocutaneous albinism. (PMID: 19865097) Wei A … Li W (The Journal of investigative dermatology 2010) 3 22 40
  3. Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. (PMID: 19384953) Nan H … Han J (International journal of cancer 2009) 3 22 40
  4. Birth prevalence and mutation spectrum in danish patients with autosomal recessive albinism. (PMID: 19060277) Grønskov K … Rosenberg T (Investigative ophthalmology & visual science 2009) 3 22 40
  5. SLC45A2: a novel malignant melanoma-associated gene. (PMID: 18563784) Fernandez LP … Ribas G (Human mutation 2008) 3 22 40

Products for TYRP1 Gene

Sources for TYRP1 Gene