Aliases for TYMS Gene
External Ids for TYMS Gene
Previous HGNC Symbols for TYMS Gene
Previous GeneCards Identifiers for TYMS Gene
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
GeneCards Summary for TYMS Gene
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include Mucositis and Rectum Cancer. Among its related pathways are One carbon pool by folate and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and mRNA binding. An important paralog of this gene is DHFR.
UniProtKB/Swiss-Prot Summary for TYMS Gene
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.