Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary ... See more...

Aliases for TYMS Gene

Aliases for TYMS Gene

  • Thymidylate Synthetase 2 3 5
  • Thymidylate Synthase 3 4
  • EC 2.1.1.45 4 50
  • TSase 3 4
  • TMS 2 3
  • TS 3 4
  • HST422 3
  • HsT422 2
  • Tsase 2
  • TYMS 5

External Ids for TYMS Gene

Previous HGNC Symbols for TYMS Gene

  • TS

Previous GeneCards Identifiers for TYMS Gene

  • GC18U990034
  • GC18P000645
  • GC18P000647

Summaries for TYMS Gene

Entrez Gene Summary for TYMS Gene

  • Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

CIViC Summary for TYMS Gene

GeneCards Summary for TYMS Gene

TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include Mucositis and Rectum Cancer. Among its related pathways are One carbon pool by folate and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and mRNA binding. An important paralog of this gene is DHFR.

UniProtKB/Swiss-Prot Summary for TYMS Gene

  • Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

Tocris Summary for TYMS Gene

Gene Wiki entry for TYMS Gene

PharmGKB "VIP" Summary for TYMS Gene

No data available for Rfam classification and piRNA Summary for TYMS Gene

Genomics for TYMS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TYMS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TYMS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TYMS

Top Transcription factor binding sites by QIAGEN in the TYMS gene promoter:
  • AML1a
  • ARP-1
  • ATF-2
  • Egr-1
  • FAC1
  • MRF-2
  • p53
  • POU2F1
  • POU2F1a
  • RREB-1

Genomic Locations for TYMS Gene

Latest Assembly
chr18:657,653-673,578
(GRCh38/hg38)
Size:
15,926 bases
Orientation:
Plus strand

Previous Assembly
chr18:657,653-673,578
(GRCh37/hg19 by Entrez Gene)
Size:
15,926 bases
Orientation:
Plus strand

chr18:657,604-673,578
(GRCh37/hg19 by Ensembl)
Size:
15,975 bases
Orientation:
Plus strand

Genomic View for TYMS Gene

Genes around TYMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYMS Gene

Proteins for TYMS Gene

  • Protein details for TYMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04818-TYSY_HUMAN
    Recommended name:
    Thymidylate synthase
    Protein Accession:
    P04818
    Secondary Accessions:
    • Q8WYK3
    • Q8WYK4

    Protein attributes for TYMS Gene

    Size:
    313 amino acids
    Molecular mass:
    35716 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • [Isoform 2]: Expressed both in normal and cancerous tissues.
    • [Isoform 3]: Expressed only in cancerous tissues.

    Three dimensional structures from OCA and Proteopedia for TYMS Gene

    Alternative splice isoforms for TYMS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TYMS Gene

Selected DME Specific Peptides for TYMS Gene

P04818:
  • FGMQARY
  • MALPPCH
  • DRTGTGT
  • GTLSVFG
  • YGFQWRH
  • CQLYQRS
  • DMGLGVPFN
  • FIHTLGDAH
  • HTLGDAHIY
  • GDAHIYLNH
  • LLTYMIA
  • DRRIIMCAWNP
  • PFNIASY
  • REPRPFP
  • LYQRSGD
  • FPLLTTK
  • GDLGPVYG
  • EELLWFI
  • IWDANGSR

Post-translational modifications for TYMS Gene

  • Ubiquitination at Lys77, Lys169, Lys104, Lys107, Lys292, and Lys308
  • Modification sites at PhosphoSitePlus

Other Protein References for TYMS Gene

Antibodies for research

Domains & Families for TYMS Gene

Gene Families for TYMS Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TYMS Gene

Suggested Antigen Peptide Sequences for TYMS Gene

GenScript: Design optimal peptide antigens:
  • Thymidylate synthase (Q53Y97_HUMAN)
  • Thymidylate synthase (Q8WYK4_HUMAN)
  • Thymidylate synthase (TYSY_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04818

UniProtKB/Swiss-Prot:

TYSY_HUMAN :
  • Belongs to the thymidylate synthase family.
Family:
  • Belongs to the thymidylate synthase family.
genes like me logo Genes that share domains with TYMS: view

Function for TYMS Gene

Molecular function for TYMS Gene

UniProtKB/Swiss-Prot Function:
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP; Xref=Rhea:RHEA:12104, ChEBI:CHEBI:15636, ChEBI:CHEBI:57451, ChEBI:CHEBI:63528, ChEBI:CHEBI:246422; EC=2.1.1.45;.
GENATLAS Biochemistry:
thymidylate synthetase,pyrimidine biosynthetic pathway

Enzyme Numbers (IUBMB) for TYMS Gene

Phenotypes From GWAS Catalog for TYMS Gene

Gene Ontology (GO) - Molecular Function for TYMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, mRNA regulatory element binding IDA 1924359
GO:0003729 mRNA binding IEA --
GO:0004799 thymidylate synthase activity IBA,TAS 1924359
GO:0005542 folic acid binding IC 15093541
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with TYMS: view
genes like me logo Genes that share phenotypes with TYMS: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYMS

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TYMS Gene

Localization for TYMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TYMS Gene

Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYMS gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
cytoskeleton 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TYMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21876188
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IDA 21876188
GO:0005739 mitochondrion IBA,IDA 21876188
GO:0005743 mitochondrial inner membrane IEA,IDA 21876188
genes like me logo Genes that share ontologies with TYMS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TYMS Gene

Pathways & Interactions for TYMS Gene

genes like me logo Genes that share pathways with TYMS: view

UniProtKB/Swiss-Prot P04818-TYSY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis.

SIGNOR curated interactions for TYMS Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TYMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0006206 pyrimidine nucleobase metabolic process IEA --
GO:0006231 dTMP biosynthetic process IBA,IDA 8845352
GO:0006235 dTTP biosynthetic process IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with TYMS: view

Drugs & Compounds for TYMS Gene

(95) Drugs for TYMS Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pemetrexed Approved, Investigational Pharma Target, inhibitor, Biomarker TS, DHFR,GARFT and AICARFT inhibitor, DHFR and Thymidylate synthase inhibitor, Anti-Folates 914
Raltitrexed Approved, Investigational Pharma Target, inhibitor 50
Capecitabine Approved, Investigational Pharma Target, inhibitor, Biomarker RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1763
Fluorouracil Approved Pharma Target, Enzyme, other/unknown, substrate, inhibitor RNA processing inhibitor and thymidylate synthase inhibitor 2449
Floxuridine Approved Pharma Target, inhibitor Antineoplastic antimetabolite, Inhibitor of thymidylate synthetase; anticancer agent, RNA and DNA synthesis inhibitor 59

(63) Additional Compounds for TYMS Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Trifluorothymidine
70-00-8
5,10-Methylene-THF
  • (6R)-5,10-Methylenetetrahydrofolate
  • (6R)-5,10-Methylenetetrahydrofolic acid
  • 5,10-Methenyltetrahydropteroylglutamate
  • 5,10-Methylene-6-hydrofolate
  • 5,10-Methylene-6-hydrofolic acid
31690-11-6
Bz 423
216691-95-1

(5) Tocris Compounds for TYMS Gene

Compound Action Cas Number
Borrelidin Antiangiogenic; inhibits threonyl-tRNA synthetase 7184-60-3
Bz 423 ATP synthase inhibitor; proapoptotic 216691-95-1
Floxuridine Inhibitor of thymidylate synthetase; anticancer agent 50-91-9
Trifluorothymidine Thymidylate synthase inhibitor; induces DNA fragmentation 70-00-8
Zoledronic Acid Potent farnesyl diphosphate (FPP) synthase inhibitor 118072-93-8

(9) ApexBio Compounds for TYMS Gene

Compound Action Cas Number
Doxifluridine 3094-09-5
Leucovorin Calcium Derivative of folic acid 6035-45-6
Nolatrexed (AG-337) Non-classical thymidylate synthase inhibitor 152946-68-4
Pemetrexed TS, DHFR,GARFT and AICARFT inhibitor 150399-23-8
Pemetrexed disodium hemipenta hydrate 357166-30-4
Raltitrexed 112887-68-0
Risedronate Sodium FPP synthase inhibitor 115436-72-1
Triacsin C 76896-80-5
Triflurdine (Viroptic) Anti-herpesvirus antiviral drug 70-00-8
genes like me logo Genes that share compounds with TYMS: view

Drug products for research

Transcripts for TYMS Gene

mRNA/cDNA for TYMS Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYMS

Alternative Splicing Database (ASD) splice patterns (SP) for TYMS Gene

No ASD Table

Relevant External Links for TYMS Gene

GeneLoc Exon Structure for
TYMS

Expression for TYMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TYMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TYMS Gene

This gene is overexpressed in Bone (28.6), Fetal Liver (9.7), Lymph node (9.1), and Platelet (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TYMS Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TYMS

SOURCE GeneReport for Unigene cluster for TYMS Gene:

Hs.369762

Evidence on tissue expression from TISSUES for TYMS Gene

  • Bone marrow(4.6)
  • Skin(4.5)
  • Nervous system(3.4)
  • Intestine(3.3)
  • Liver(3)
  • Lymph node(2.8)
  • Kidney(2.5)
  • Spleen(2.5)
  • Blood(2.5)
  • Lung(2.5)
  • Bone(2.4)
  • Eye(2.4)
  • Stomach(2.4)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with TYMS: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TYMS Gene

Orthologs for TYMS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TYMS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TYMS 29 30
  • 99.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TYMS 29
  • 89.56 (n)
TS 30
  • 79 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TYMS 29 30
  • 88.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tyms 29 16 30
  • 87.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tyms 29
  • 86.1 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 84 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia TYMS 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TYMS 29 30
  • 79.43 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TYMS 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tyms 29
  • 74.17 (n)
Str.1772 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.17306 29
Zebrafish
(Danio rerio)
Actinopterygii tyms 29 30
  • 74.41 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9644 29
Fruit Fly
(Drosophila melanogaster)
Insecta Ts 29 30 31
  • 64.4 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010457 29
  • 62.44 (n)
Worm
(Caenorhabditis elegans)
Secernentea Y110A7A.4 29 30 31
  • 62.91 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC21 29 30 32
  • 60.8 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR219C 29
  • 60.68 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07843g 29
  • 59.62 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons THY-2 29
  • 61.54 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9056 29
Soybean
(Glycine max)
eudicotyledons Gma.483 29
Barley
(Hordeum vulgare)
Liliopsida Hv.7395 29
Rice
(Oryza sativa)
Liliopsida Os.8307 29
Wheat
(Triticum aestivum)
Liliopsida Ta.29395 29
Corn
(Zea mays)
Liliopsida Zm.482 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11299 30
  • 69 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU10053 29
  • 61.27 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC15E1.04 29
  • 57.89 (n)
Species where no ortholog for TYMS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TYMS Gene

ENSEMBL:
Gene Tree for TYMS (if available)
TreeFam:
Gene Tree for TYMS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TYMS: view image
Alliance of Genome Resources:
Additional Orthologs for TYMS

Paralogs for TYMS Gene

Paralogs for TYMS Gene

Pseudogenes.org Pseudogenes for TYMS Gene

genes like me logo Genes that share paralogs with TYMS: view

Variants for TYMS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TYMS Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs11280056 Drug Response: capecitabine response - Efficacy; fluorouracil response - Efficacy 673,443(+) TTTAAAG/T
NM_001071.4(TYMS):c.*450_*455del
THREE_PRIME_UTR
rs143415597 Likely Benign: not provided 671,433(+) C/T
NM_001071.4(TYMS):c.786C>T (p.Ile262=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs1446885716 Likely Benign: not provided 657,838(+) G/A
NM_001071.4(TYMS):c.96G>A (p.Gln32=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TYMS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TYMS Gene

Variant ID Type Subtype PubMed ID
dgv3307n100 CNV gain 25217958
dgv5810n54 CNV gain 21841781
dgv967e212 CNV loss 25503493
esv1982616 CNV deletion 18987734
esv2023053 CNV deletion 18987734
esv2521731 CNV deletion 19546169
esv2716652 CNV deletion 23290073
esv2716653 CNV deletion 23290073
esv2716654 CNV deletion 23290073
esv2716655 CNV deletion 23290073
esv3353997 CNV duplication 20981092
esv3641496 CNV loss 21293372
esv3641497 CNV gain 21293372
esv3641503 CNV gain 21293372
esv3893055 CNV gain 25118596
esv4728 CNV loss 18987735
esv9315 CNV loss 19470904
nsv1060188 CNV gain 25217958
nsv1146664 CNV insertion 26484159
nsv482935 CNV loss 15286789
nsv528169 CNV loss 19592680
nsv576228 CNV loss 21841781
nsv576236 CNV gain 21841781
nsv576239 CNV gain 21841781
nsv576242 CNV gain 21841781
nsv833577 CNV gain+loss 17160897
nsv954107 CNV deletion 24416366

Variation tolerance for TYMS Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TYMS Gene

Human Gene Mutation Database (HGMD)
TYMS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TYMS
Leiden Open Variation Database (LOVD)
TYMS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYMS Gene

Disorders for TYMS Gene

MalaCards: The human disease database

(37) MalaCards diseases for TYMS Gene - From: COP and GCD

Disorder Aliases PubMed IDs
mucositis
  • inflammatory disease of mucous membrane
rectum cancer
  • cancer of rectum
adult acute lymphocytic leukemia
  • adult acute lymphoid leukemia
gastrointestinal carcinoma
  • gastrointestinal neoplasms
colon adenocarcinoma
  • adenocarcinoma of colon
- elite association - COSMIC cancer census association via MalaCards
Search TYMS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TYMS

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TYMS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TYMS Gene

Publications for TYMS Gene

  1. Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer. (PMID: 20372850) Shintani M … Kamoshida S (Oncology reports 2010) 3 22 25
  2. Correlation between thymidylate synthase gene variants, RNA and protein levels in primary colorectal adenocarcinomas. (PMID: 20515563) Kristensen MH … Mejer J (The Journal of international medical research 2010) 3 22 40
  3. MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children. (PMID: 20310006) de Lima EL … Muniz MT (Pediatric blood & cancer 2010) 3 22 40
  4. Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6. (PMID: 20047592) Han SW … Kim TY (Cancer science 2010) 3 22 40
  5. Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer. (PMID: 20447923) Shitara K … Matsuo K (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 40

Products for TYMS Gene

  • Addgene plasmids for TYMS

Sources for TYMS Gene