Aliases for TYK2 Gene
External Ids for TYK2 Gene
Previous GeneCards Identifiers for TYK2 Gene
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
GeneCards Summary for TYK2 Gene
TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Lymphomatoid Papulosis. Among its related pathways are Th1 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.
UniProtKB/Swiss-Prot Summary for TYK2 Gene
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.