This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may ... See more...

Aliases for TYK2 Gene

Aliases for TYK2 Gene

  • Tyrosine Kinase 2 2 3 5
  • Non-Receptor Tyrosine-Protein Kinase TYK2 3 4
  • EC 2.7.10.2 4 52
  • EC 2.7.10 52
  • IMD35 3
  • JTK1 3

External Ids for TYK2 Gene

Previous GeneCards Identifiers for TYK2 Gene

  • GC19M010582
  • GC19M010684
  • GC19M010306
  • GC19M010322
  • GC19M010461
  • GC19M010041

Summaries for TYK2 Gene

Entrez Gene Summary for TYK2 Gene

  • This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

GeneCards Summary for TYK2 Gene

TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Lymphomatoid Papulosis. Among its related pathways are Th1 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.

UniProtKB/Swiss-Prot Summary for TYK2 Gene

  • Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Gene Wiki entry for TYK2 Gene

Additional gene information for TYK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TYK2 Gene

Genomics for TYK2 Gene

GeneHancer (GH) Regulatory Elements for TYK2 Gene

Promoters and enhancers for TYK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 520.4 +0.1 71 2.2 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 PHF8 FOS TEAD4 ZIC2 TYK2 lnc-CDC37-1 lnc-PDE4A-3 ILF3 FBXL12 KRI1 ZNF561 RAVER1 LOC100419831 PPAN
GH19J010368 Promoter 0.3 EPDnew 500.4 +12.4 12426 0.1 TYK2 piR-50437-333 lnc-CDC37-1
GH19J010100 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +276.2 276185 8.3 RXRA ZBTB40 ZNF217 EP300 SIN3A MYC NRF1 POLR2G USF1 SP1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 LOC100419831 FBXL12 ZNF561 ILF3 ZNF317 ZNF559
GH19J010415 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 10.4 -40.3 -40344 10.6 EP300 RXRA HNRNPK ZNF217 CTCF ZSCAN5C TCF12 SIN3A NRF1 MYC PDE4A CDC37 LOC100419831 ZNF266 RAVER1 DNMT1 KRI1 ZNF561 EIF3G ILF3
GH19J010601 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.3 -223.5 -223485 4.5 ZNF217 EP300 NRF1 USF1 PHF8 ZIC2 ZBTB10 ZBTB26 TARDBP KLF7 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 ZNF627 PRKCSH TYK2 DNM2 S1PR5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TYK2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TYK2

Top Transcription factor binding sites by QIAGEN in the TYK2 gene promoter:
  • AhR
  • Arnt
  • E47
  • Ik-1
  • MAZR
  • Pbx1a
  • STAT3
  • STAT5A
  • YY1
  • ZID

Genomic Locations for TYK2 Gene

Genomic Locations for TYK2 Gene
chr19:10,350,528-10,380,572
(GRCh38/hg38)
Size:
30,045 bases
Orientation:
Minus strand
chr19:10,461,204-10,491,352
(GRCh37/hg19)
Size:
30,149 bases
Orientation:
Minus strand

Genomic View for TYK2 Gene

Genes around TYK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYK2 Gene

Proteins for TYK2 Gene

  • Protein details for TYK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29597-TYK2_HUMAN
    Recommended name:
    Non-receptor tyrosine-protein kinase TYK2
    Protein Accession:
    P29597
    Secondary Accessions:
    • Q6QB10
    • Q96CH0

    Protein attributes for TYK2 Gene

    Size:
    1187 amino acids
    Molecular mass:
    133650 Da
    Quaternary structure:
    • Interacts with JAKMIP1.

    Three dimensional structures from OCA and Proteopedia for TYK2 Gene

neXtProt entry for TYK2 Gene

Selected DME Specific Peptides for TYK2 Gene

P29597:
  • RDLAARN
  • PFIKLSDPG
  • QLASALSYLE
  • DSPVFWYAPECL
  • AARNVLL
  • GERLPRP
  • ASLMSQVS

Post-translational modifications for TYK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for TYK2
  • Boster Bio Antibodies for TYK2

Domains & Families for TYK2 Gene

Gene Families for TYK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TYK2 Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine-protein kinase (E9PM19_HUMAN)
  • Tyrosine-protein kinase (F5H7K8_HUMAN)
  • Non-receptor tyrosine-protein kinase TYK2 (TYK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P29597

UniProtKB/Swiss-Prot:

TYK2_HUMAN :
  • The FERM domain mediates interaction with JAKMIP1.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Domain:
  • The FERM domain mediates interaction with JAKMIP1.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
genes like me logo Genes that share domains with TYK2: view

Function for TYK2 Gene

Molecular function for TYK2 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=. ;.
GENATLAS Biochemistry:
tyrosine kinase 2,non receptor type,class III,expressed in lymphoid cells (JAK family),involved in signal transduction of cytokine receptors,mediating the activation of STAT proteins

Enzyme Numbers (IUBMB) for TYK2 Gene

Phenotypes From GWAS Catalog for TYK2 Gene

Gene Ontology (GO) - Molecular Function for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS --
GO:0005131 growth hormone receptor binding IPI 10502458
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TYK2: view
genes like me logo Genes that share phenotypes with TYK2: view

Human Phenotype Ontology for TYK2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TYK2 Gene

MGI Knock Outs for TYK2:
  • Tyk2 Tyk2<tm1Biat>
  • Tyk2 Tyk2<tm1Shmd>
  • Tyk2 Tyk2<tm2b(EUCOMM)Hmgu>

CRISPR Products

miRNA for TYK2 Gene

miRTarBase miRNAs that target TYK2

Clone Products

  • Addgene plasmids for TYK2

No data available for Transcription Factor Targets and HOMER Transcription for TYK2 Gene

Localization for TYK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYK2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 3
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10502458
GO:0005737 cytoplasm IDA 10502458
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TYK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TYK2 Gene

Pathways & Interactions for TYK2 Gene

PathCards logo

SuperPathways for TYK2 Gene

SuperPathway Contained pathways
1 Th17 cell differentiation
.36
.01
2 Immune response IL-23 signaling pathway
.44
.44
.36
3 Measles
.35
4 Th1 Differentiation Pathway
5 Interleukin-6 family signaling
genes like me logo Genes that share pathways with TYK2: view

Pathways by source for TYK2 Gene

8 GeneGo (Thomson Reuters) pathways for TYK2 Gene
  • Development PDGF signaling via STATs and NF-kB
  • Immune response IFN alpha/beta signaling pathway
  • Immune response IL-10 signaling pathway
  • Immune response IL-12-induced IFN-gamma production
  • Immune response IL-22 signaling pathway
8 Qiagen pathways for TYK2 Gene
  • CNTF Signaling
  • IL-10 Pathway
  • IL-22 Pathway
  • Interferon Pathway
  • JAK-STAT Pathway
2 Cell Signaling Technology pathways for TYK2 Gene
1 GeneTex pathway for TYK2 Gene

SIGNOR curated interactions for TYK2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 2216457
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with TYK2: view

Drugs & Compounds for TYK2 Gene

(25) Drugs for TYK2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Tofacitinib Approved, Investigational Pharma Target 152
Fedratinib Approved, Investigational Pharma 0
2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Experimental Pharma Target 0
Bardoxolone methyl Investigational Pharma IKK inhibitor, potent antioxidant inflammation modulator 0

(10) Additional Compounds for TYK2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(8) ApexBio Compounds for TYK2 Gene

Compound Action Cas Number
AZ 960 JAKs inhibitor 905586-69-8
Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator 218600-53-4
GLPG0634 JAK1 inhibitor 1206161-97-8
NVP-BSK805 ATP-competitive JAK2 inhibitor 1092499-93-8
Pyridone 6 Pan-JAK inhibitor 457081-03-7
S-Ruxolitinib (INCB018424) JAK1/2 inhibitor,potent and selective 941685-37-6
WHI-P154 JAK3 inhibitor 211555-04-3
ZM 39923 HCl JAK3 inhibitor,potent and selective 1021868-92-7
genes like me logo Genes that share compounds with TYK2: view

Transcripts for TYK2 Gene

mRNA/cDNA for TYK2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for TYK2

Alternative Splicing Database (ASD) splice patterns (SP) for TYK2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13:
SP14:
SP15:
SP16:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ·
SP1: - - - - - - -
SP2:
SP3: - - - - - -
SP4:
SP5:
SP6: - -
SP7: -
SP8: - - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14: -
SP15: -
SP16: - - -

ExUns: 30c · 30d · 30e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TYK2 Gene

GeneLoc Exon Structure for
TYK2

Expression for TYK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TYK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TYK2 Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for TYK2 Gene

This gene is overexpressed in Liver (42.9) and Spleen (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TYK2 Gene



Protein tissue co-expression partners for TYK2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TYK2

SOURCE GeneReport for Unigene cluster for TYK2 Gene:

Hs.75516

mRNA Expression by UniProt/SwissProt for TYK2 Gene:

P29597-TYK2_HUMAN
Tissue specificity: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

Evidence on tissue expression from TISSUES for TYK2 Gene

  • Nervous system(4.6)
  • Kidney(4.4)
  • Blood(2.7)
  • Bone marrow(2.7)
  • Spleen(2.7)
  • Lung(2.6)
  • Skin(2.6)
  • Lymph node(2.4)
  • Intestine(2.3)
  • Muscle(2.1)
  • Heart(2)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TYK2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
Regions:
Head and neck:
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • skull
  • tooth
Thorax:
  • lung
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with TYK2: view

Orthologs for TYK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TYK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYK2 31 30
  • 99.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TYK2 31 30
  • 85.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TYK2 31 30
  • 84.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tyk2 17 31 30
  • 80.95 (n)
rat
(Rattus norvegicus)
Mammalia Tyk2 30
  • 80.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 72 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TYK2 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TYK2 31
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYK2 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tyk2 30
  • 63.79 (n)
Str.3707 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.12998 30
zebrafish
(Danio rerio)
Actinopterygii tyk2 31 30
  • 58.14 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToMany
Species where no ortholog for TYK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYK2 Gene

ENSEMBL:
Gene Tree for TYK2 (if available)
TreeFam:
Gene Tree for TYK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TYK2: view image

Paralogs for TYK2 Gene

genes like me logo Genes that share paralogs with TYK2: view

Variants for TYK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TYK2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
565570 Uncertain Significance: Tyrosine kinase 2 deficiency 10,365,836(-) C/T MISSENSE_VARIANT
571990 Uncertain Significance: Tyrosine kinase 2 deficiency 10,366,457(-) G/A MISSENSE_VARIANT
574313 Uncertain Significance: Tyrosine kinase 2 deficiency 10,378,364(-) C/A MISSENSE_VARIANT
576183 Uncertain Significance: Tyrosine kinase 2 deficiency 10,366,521(-) C/G MISSENSE_VARIANT
576188 Uncertain Significance: Tyrosine kinase 2 deficiency 10,354,054(-) A/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TYK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TYK2 Gene

Variant ID Type Subtype PubMed ID
esv24860 CNV gain 19812545
esv3643653 CNV loss 21293372
nsv1072322 CNV deletion