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Aliases for TYK2 Gene

Aliases for TYK2 Gene

  • Tyrosine Kinase 2 2 3 5
  • EC 2.7.10.2 4 56
  • Non-Receptor Tyrosine-Protein Kinase TYK2 3
  • EC 2.7.10 56
  • IMD35 3
  • JTK1 3

External Ids for TYK2 Gene

Previous GeneCards Identifiers for TYK2 Gene

  • GC19M010582
  • GC19M010684
  • GC19M010306
  • GC19M010322
  • GC19M010461
  • GC19M010041

Summaries for TYK2 Gene

Entrez Gene Summary for TYK2 Gene

  • This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

GeneCards Summary for TYK2 Gene

TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Lymphomatoid Papulosis. Among its related pathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.

UniProtKB/Swiss-Prot for TYK2 Gene

  • Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Gene Wiki entry for TYK2 Gene

Additional gene information for TYK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYK2 Gene

Genomics for TYK2 Gene

GeneHancer (GH) Regulatory Elements for TYK2 Gene

Promoters and enhancers for TYK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I010379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 570.5 +0.1 149 1.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 TYK2 GC19P010382 ILF3 KRI1 FBXL12 DNMT1 PPAN RAVER1 LOC100419831 ZNF561
GH19I010427 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 20 -49.9 -49889 6.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT SIN3A YBX1 ZNF143 ZNF592 MEF2D PDE4A ZNF266 TYK2 ILF3 FBXL12 RAVER1 EIF3G KRI1 ZNF561 ICAM1
GH19I010651 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.6 -273.5 -273538 5.1 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 ILF3 ILF3-AS1 GC19M010652 PIR56383 PIR39434 FBXL12 ZNF627 LOC100419831 RAVER1 KRI1
GH19I010415 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 16.4 -36.0 -35970 2 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC PDE4A LOC100419831 ZNF266 KRI1 ILF3 RAVER1 FBXL12 PPAN ZNF561 DNMT1
GH19I010419 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.6 -39.5 -39524 2 HDGF PKNOX1 CLOCK ARNT SIN3A YBX1 ZNF2 POLR2B CBX5 ZNF213 CDC37 PDE4A ILF3 KRI1 ZNF266 DNMT1 PPAN FBXL12 RAVER1 TYK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TYK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TYK2 gene promoter:

Genomic Locations for TYK2 Gene

Genomic Locations for TYK2 Gene
chr19:10,350,528-10,380,676
(GRCh38/hg38)
Size:
30,149 bases
Orientation:
Minus strand
chr19:10,461,204-10,491,352
(GRCh37/hg19)

Genomic View for TYK2 Gene

Genes around TYK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYK2 Gene

Proteins for TYK2 Gene

  • Protein details for TYK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29597-TYK2_HUMAN
    Recommended name:
    Non-receptor tyrosine-protein kinase TYK2
    Protein Accession:
    P29597
    Secondary Accessions:
    • Q6QB10
    • Q96CH0

    Protein attributes for TYK2 Gene

    Size:
    1187 amino acids
    Molecular mass:
    133650 Da
    Quaternary structure:
    • Interacts with JAKMIP1.

    Three dimensional structures from OCA and Proteopedia for TYK2 Gene

neXtProt entry for TYK2 Gene

Selected DME Specific Peptides for TYK2 Gene

P29597:
  • RDLAARN
  • PFIKLSDPG
  • QLASALSYLE
  • DSPVFWYAPECL
  • AARNVLL
  • GERLPRP
  • ASLMSQVS

Post-translational modifications for TYK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TYK2 Gene

Gene Families for TYK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TYK2 Gene

Graphical View of Domain Structure for InterPro Entry

P29597

UniProtKB/Swiss-Prot:

TYK2_HUMAN :
  • The FERM domain mediates interaction with JAKMIP1.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Domain:
  • The FERM domain mediates interaction with JAKMIP1.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
genes like me logo Genes that share domains with TYK2: view

Function for TYK2 Gene

Molecular function for TYK2 Gene

GENATLAS Biochemistry:
tyrosine kinase 2,non receptor type,class III,expressed in lymphoid cells (JAK family),involved in signal transduction of cytokine receptors,mediating the activation of STAT proteins
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Enzyme Numbers (IUBMB) for TYK2 Gene

Phenotypes From GWAS Catalog for TYK2 Gene

Gene Ontology (GO) - Molecular Function for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA,TAS --
GO:0005131 growth hormone receptor binding IPI 10502458
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TYK2: view
genes like me logo Genes that share phenotypes with TYK2: view

Human Phenotype Ontology for TYK2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TYK2 Gene

MGI Knock Outs for TYK2:

miRNA for TYK2 Gene

miRTarBase miRNAs that target TYK2

Clone Products

  • Addgene plasmids for TYK2

No data available for Transcription Factor Targets and HOMER Transcription for TYK2 Gene

Localization for TYK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYK2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 3
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10502458
GO:0005737 cytoplasm IDA 10502458
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TYK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TYK2 Gene

Pathways & Interactions for TYK2 Gene

genes like me logo Genes that share pathways with TYK2: view

SIGNOR curated interactions for TYK2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 2216457
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration IBA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with TYK2: view

Drugs & Compounds for TYK2 Gene

(24) Drugs for TYK2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tofacitinib Approved, Investigational Pharma Target 112
2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Experimental Pharma Target 0
AT9283 Investigational Pharma inhibitor Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
Fedratinib Investigational Pharma 0
NS-018 Investigational Pharma 0

(10) Additional Compounds for TYK2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(8) ApexBio Compounds for TYK2 Gene

Compound Action Cas Number
AZ 960 JAKs inhibitor 905586-69-8
Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator 218600-53-4
GLPG0634 JAK1 inhibitor 1206161-97-8
NVP-BSK805 ATP-competitive JAK2 inhibitor 1092499-93-8
Pyridone 6 Pan-JAK inhibitor 457081-03-7
S-Ruxolitinib (INCB018424) JAK1/2 inhibitor,potent and selective 941685-37-6
WHI-P154 JAK3 inhibitor 211555-04-3
ZM 39923 HCl JAK3 inhibitor,potent and selective 1021868-92-7
genes like me logo Genes that share compounds with TYK2: view

Drug Products

Transcripts for TYK2 Gene

Unigene Clusters for TYK2 Gene

Tyrosine kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for TYK2

Alternative Splicing Database (ASD) splice patterns (SP) for TYK2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13:
SP14:
SP15:
SP16:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ·
SP1: - - - - - - -
SP2:
SP3: - - - - - -
SP4:
SP5:
SP6: - -
SP7: -
SP8: - - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14: -
SP15: -
SP16: - - -

ExUns: 30c · 30d · 30e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TYK2 Gene

GeneLoc Exon Structure for
TYK2
ECgene alternative splicing isoforms for
TYK2

Expression for TYK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TYK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TYK2 Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for TYK2 Gene

This gene is overexpressed in Liver (42.9) and Spleen (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TYK2 Gene



Protein tissue co-expression partners for TYK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TYK2 Gene:

TYK2

SOURCE GeneReport for Unigene cluster for TYK2 Gene:

Hs.75516

mRNA Expression by UniProt/SwissProt for TYK2 Gene:

P29597-TYK2_HUMAN
Tissue specificity: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

Evidence on tissue expression from TISSUES for TYK2 Gene

  • Nervous system(4.6)
  • Kidney(4.4)
  • Blood(2.7)
  • Bone marrow(2.7)
  • Spleen(2.7)
  • Lung(2.6)
  • Skin(2.6)
  • Lymph node(2.4)
  • Intestine(2.3)
  • Muscle(2.1)
  • Heart(2)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TYK2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
Regions:
Head and neck:
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • skull
  • tooth
Thorax:
  • lung
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with TYK2: view

Orthologs for TYK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TYK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYK2 33 34
  • 99.06 (n)
cow
(Bos Taurus)
Mammalia TYK2 33 34
  • 85.28 (n)
dog
(Canis familiaris)
Mammalia TYK2 33 34
  • 84.45 (n)
mouse
(Mus musculus)
Mammalia Tyk2 33 16 34
  • 80.95 (n)
rat
(Rattus norvegicus)
Mammalia Tyk2 33
  • 80.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TYK2 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TYK2 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYK2 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tyk2 33
  • 63.79 (n)
Str.3707 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12998 33
zebrafish
(Danio rerio)
Actinopterygii tyk2 33 34
  • 58.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for TYK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYK2 Gene

ENSEMBL:
Gene Tree for TYK2 (if available)
TreeFam:
Gene Tree for TYK2 (if available)

Paralogs for TYK2 Gene

Paralogs for TYK2 Gene

genes like me logo Genes that share paralogs with TYK2: view

Variants for TYK2 Gene

Sequence variations from dbSNP and Humsavar for TYK2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs114073289 likely-benign, benign, not specified, Tyrosine kinase 2 deficiency 10,351,151(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs12720221 likely-benign, Familial Atypical Mycobacteriosis, Autosomal Recessive 10,379,745(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs12720263 likely-benign, benign, Familial Atypical Mycobacteriosis, Autosomal Recessive, not specified, Tyrosine kinase 2 deficiency 10,366,456(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs12720266 likely-benign, benign, Familial Atypical Mycobacteriosis, Autosomal Recessive, not specified, Tyrosine kinase 2 deficiency 10,365,586(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant
rs12720276 likely-benign, benign, Familial Atypical Mycobacteriosis, Autosomal Recessive, not specified, Tyrosine kinase 2 deficiency 10,361,881(-) A/C/G coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TYK2 Gene

Variant ID Type Subtype PubMed ID
esv24860 CNV gain 19812545
esv3643653 CNV loss 21293372
nsv1072322 CNV deletion 25765185
nsv1136277 CNV deletion 24896259
nsv2415 CNV insertion 18451855
nsv470124 CNV gain 18288195
nsv470125 CNV loss 18288195
nsv518008 CNV gain 19592680

Variation tolerance for TYK2 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TYK2 Gene

Human Gene Mutation Database (HGMD)
TYK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TYK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYK2 Gene

Disorders for TYK2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for TYK2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 35
  • imd35
lymphomatoid papulosis
  • lyp
primary cutaneous anaplastic large cell lymphoma
  • primary c-alcl
mixed lacrimal gland cancer
  • carcinoma ex pleomorphic adenoma of lacrimal gland
rheumatoid factor-negative juvenile idiopathic arthritis
  • juvenile rheumatoid factor-negative polyarthritis
- elite association - COSMIC cancer census association via MalaCards
Search TYK2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TYK2_HUMAN
  • Immunodeficiency 35 (IMD35) [MIM:611521]: A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. {ECO:0000269 PubMed:17088085}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TYK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TYK2: view

No data available for Genatlas for TYK2 Gene

Publications for TYK2 Gene

  1. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. (PMID: 19293837) Ban M … Compston A (European journal of human genetics : EJHG 2009) 3 22 44 58
  2. Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. (PMID: 19440814) Kyogoku C … Kumagai S (Modern rheumatology 2009) 3 22 44 58
  3. Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus. (PMID: 19567624) Hellquist A … Kere J (The Journal of rheumatology 2009) 3 22 44 58
  4. Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population. (PMID: 19653082) Sato K … Tsukamoto K (Journal of clinical immunology 2009) 3 22 44 58
  5. Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families. (PMID: 17384181) Cunninghame Graham DS … Vyse TJ (Rheumatology (Oxford, England) 2007) 3 22 44 58

Products for TYK2 Gene

  • Addgene plasmids for TYK2