Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TXNRD3 Gene

Aliases for TXNRD3 Gene

  • Thioredoxin Reductase 3 2 3 5
  • Thioredoxin And Glutathione Reductase 3 4
  • Thioredoxin Glutathione Reductase 2 3
  • Thioredoxin Reductase TR2 3 4
  • EC 1.8.1.9 4 56
  • TRXR3 3 4
  • TGR 3 4
  • Thioredoxin Reductase 2 3
  • EC 1.8.1 56
  • TR2 3

External Ids for TXNRD3 Gene

Previous GeneCards Identifiers for TXNRD3 Gene

  • GC03M127607
  • GC03M127646
  • GC03M127808
  • GC03U901368
  • GC03M126327
  • GC03M123706
  • GC03M126292
  • GC03M126572

Summaries for TXNRD3 Gene

Entrez Gene Summary for TXNRD3 Gene

  • The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]

GeneCards Summary for TXNRD3 Gene

TXNRD3 (Thioredoxin Reductase 3) is a Protein Coding gene. Diseases associated with TXNRD3 include Parasitic Helminthiasis Infectious Disease. Among its related pathways are Selenium Metabolism and Selenoproteins and Gastric cancer. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is TXNRD1.

UniProtKB/Swiss-Prot for TXNRD3 Gene

  • Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).

Additional gene information for TXNRD3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNRD3 Gene

Genomics for TXNRD3 Gene

GeneHancer (GH) Regulatory Elements for TXNRD3 Gene

Promoters and enhancers for TXNRD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I126654 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 559.6 +0.2 191 1.5 SREBF2 SIN3A DMAP1 BRCA1 ZNF48 ZNF335 THAP11 SP3 SP5 REST TXNRD3 LOC100419878
GH03I126582 Promoter 0.6 EPDnew 550.2 +72.7 72730 0.1 POLR2A TXNRD3 PIR51508 GC03M126565 GC03M126599 RNA5SP138 LOC105374090 TXNRD3NB
GH03I126608 Promoter 0.5 EPDnew 550.2 +46.6 46578 0.1 TXNRD3NB TXNRD3 LOC100419878
GH03I126522 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +128.0 128039 8.6 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 GLIS2 ATF7 CHST13 TXNRD3NB TXNRD3 NUP210P1 OR7E29P C3orf22 ZXDC UROC1
GH03I126679 Enhancer 1 Ensembl ENCODE 11.6 -24.2 -24232 0.8 RB1 SIN3A ZNF2 ZNF48 RAD21 GLIS2 ZNF143 RCOR1 EGR2 SMARCA5 CHCHD6 TXNRD3 LOC645852
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TXNRD3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TXNRD3 Gene

Genomic Locations for TXNRD3 Gene
chr3:126,607,052-126,655,155
(GRCh38/hg38)
Size:
48,104 bases
Orientation:
Minus strand
chr3:126,290,622-126,373,998
(GRCh37/hg19)

Genomic View for TXNRD3 Gene

Genes around TXNRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNRD3 Gene

Proteins for TXNRD3 Gene

  • Protein details for TXNRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VQ6-TRXR3_HUMAN
    Recommended name:
    Thioredoxin reductase 3
    Protein Accession:
    Q86VQ6
    Secondary Accessions:
    • Q6PIS8
    • Q9NNW6
    • Q9P101

    Protein attributes for TXNRD3 Gene

    Size:
    643 amino acids
    Molecular mass:
    70683 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity (By similarity).
    SequenceCaution:
    • Sequence=AAH30028.1; Type=Erroneous termination; Positions=642; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAH30028.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=AAH50032.1; Type=Erroneous termination; Positions=642; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAH50032.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TXNRD3 Gene

neXtProt entry for TXNRD3 Gene

Selected DME Specific Peptides for TXNRD3 Gene

Q86VQ6:
  • NVPTTVFTPLEYG
  • IATGERPRYLGI
  • LGPNAGE
  • IGGGSGG
  • PGKTLVVGA
  • SDDLFSLPYCPG
  • TLVVGASYV
  • PTTVFTPLEYGCCGLSEE
  • CIPKKLMHQAALLG
  • CTRKIGLE
  • TTVFTPLE
  • GDKEYCI
  • FWPLEWT

Post-translational modifications for TXNRD3 Gene

  • Ubiquitination at posLast=601601
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNRD3 Gene

Domains & Families for TXNRD3 Gene

Gene Families for TXNRD3 Gene

Suggested Antigen Peptide Sequences for TXNRD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VQ6

UniProtKB/Swiss-Prot:

TRXR3_HUMAN :
  • The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit of the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other subunit (By similarity).
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Domain:
  • The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit of the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other subunit (By similarity).
Family:
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
genes like me logo Genes that share domains with TXNRD3: view

Function for TXNRD3 Gene

Molecular function for TXNRD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
UniProtKB/Swiss-Prot Function:
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).

Enzyme Numbers (IUBMB) for TXNRD3 Gene

Gene Ontology (GO) - Molecular Function for TXNRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004791 thioredoxin-disulfide reductase activity NAS 10455115
GO:0009055 electron transfer activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA --
genes like me logo Genes that share ontologies with TXNRD3: view

Phenotypes for TXNRD3 Gene

GenomeRNAi human phenotypes for TXNRD3:
genes like me logo Genes that share phenotypes with TXNRD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNRD3

miRNA for TXNRD3 Gene

miRTarBase miRNAs that target TXNRD3

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNRD3 Gene

Localization for TXNRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNRD3 Gene

Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250 UniProtKB:Q99MD6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNRD3 gene
Compartment Confidence
mitochondrion 4
nucleus 4
endoplasmic reticulum 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with TXNRD3: view

Pathways & Interactions for TXNRD3 Gene

genes like me logo Genes that share pathways with TXNRD3: view

Pathways by source for TXNRD3 Gene

Gene Ontology (GO) - Biological Process for TXNRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000305 response to oxygen radical IBA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0022900 electron transport chain IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TXNRD3: view

No data available for SIGNOR curated interactions for TXNRD3 Gene

Drugs & Compounds for TXNRD3 Gene

(6) Drugs for TXNRD3 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Selenium Approved, Investigational, Vet_approved Pharma 193
Water Approved Pharma 0
Selenocysteine Experimental Pharma 0
motexafin gadolinium Investigational Pharma inhibitor 38

(7) Additional Compounds for TXNRD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Hydrogen selenide
  • Dihydrogen monoselenide
  • Dihydrogen selenide
  • Hydrogen selenide
  • Selane
  • Selenium dihydride
Methaneselenol
Methylselenic acid
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with TXNRD3: view

Transcripts for TXNRD3 Gene

Unigene Clusters for TXNRD3 Gene

Thioredoxin reductase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNRD3 Gene

No ASD Table

Relevant External Links for TXNRD3 Gene

GeneLoc Exon Structure for
TXNRD3
ECgene alternative splicing isoforms for
TXNRD3

Expression for TXNRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNRD3 Gene

mRNA differential expression in normal tissues according to GTEx for TXNRD3 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for TXNRD3 Gene

This gene is overexpressed in Testis (41.8), Heart (12.0), and Plasma (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TXNRD3 Gene



Protein tissue co-expression partners for TXNRD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXNRD3 Gene:

TXNRD3

SOURCE GeneReport for Unigene cluster for TXNRD3 Gene:

Hs.477475
genes like me logo Genes that share expression patterns with TXNRD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNRD3 Gene

Orthologs for TXNRD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNRD3 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia TXNRD3 33 34
  • 89.26 (n)
mouse
(Mus musculus)
Mammalia Txnrd3 33 16 34
  • 82.68 (n)
rat
(Rattus norvegicus)
Mammalia Txnrd3 33
  • 82.52 (n)
cow
(Bos Taurus)
Mammalia TRXR3 34
  • 82 (a)
OneToOne
TXNRD3 33
  • 76.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TXNRD3 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNRD3 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXNRD3 33 34
  • 75.38 (n)
lizard
(Anolis carolinensis)
Reptilia TXNRD3 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.618 33
zebrafish
(Danio rerio)
Actinopterygii txnrd1 33 34
  • 67.17 (n)
worm
(Caenorhabditis elegans)
Secernentea trxr-1 33 34
  • 56.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLR1 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
ManyToMany
CSA.8034 34
  • 60 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7635 33
Species where no ortholog for TXNRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNRD3 Gene

ENSEMBL:
Gene Tree for TXNRD3 (if available)
TreeFam:
Gene Tree for TXNRD3 (if available)

Paralogs for TXNRD3 Gene

Paralogs for TXNRD3 Gene

(6) SIMAP similar genes for TXNRD3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TXNRD3: view

Variants for TXNRD3 Gene

Sequence variations from dbSNP and Humsavar for TXNRD3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000140189 -- 126,641,505(-) C/T intron_variant
rs1000214750 -- 126,634,423(-) A/G intron_variant
rs1000230080 -- 126,626,979(-) T/C intron_variant
rs1000404690 -- 126,619,893(-) T/C intron_variant
rs1000488037 -- 126,649,192(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXNRD3 Gene

Variant ID Type Subtype PubMed ID
dgv126n6 CNV deletion 16902084
dgv2592n106 CNV deletion 24896259
dgv4852n100 CNV gain 25217958
esv1465418 CNV deletion 17803354
esv2005941 CNV deletion 18987734
esv2585777 CNV deletion 19546169
esv2725874 CNV deletion 23290073
esv2759 CNV loss 18987735
esv2834014 CNV deletion 24192839
esv3562508 CNV deletion 23714750
esv7947 CNV loss 19470904
esv987935 CNV deletion 20482838
esv987942 CNV deletion 20482838
nsv1072714 CNV deletion 25765185
nsv1144048 CNV deletion 24896259
nsv460842 CNV gain 19166990
nsv525296 CNV loss 19592680
nsv591524 CNV gain 21841781
nsv829718 CNV gain 17160897
nsv956828 CNV deletion 24416366

Variation tolerance for TXNRD3 Gene

Gene Damage Index Score: 3.79; 58.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNRD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNRD3 Gene

Disorders for TXNRD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXNRD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parasitic helminthiasis infectious disease
  • helminth infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TXNRD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TXNRD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNRD3 Gene

Publications for TXNRD3 Gene

  1. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. (PMID: 10455115) Sun QA … Gladyshev VN (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. (PMID: 20018845) Gerashchenko MV … Gladyshev VN (The Journal of biological chemistry 2010) 3 4 58
  3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 44 58
  4. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 58
  5. The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. (PMID: 22683372) Kipp AP … Brigelius-Flohé R (Biochimica et biophysica acta 2012) 3 58

Products for TXNRD3 Gene

Sources for TXNRD3 Gene

Content
Loading form....