The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encod... See more...

Aliases for TXNRD3 Gene

Aliases for TXNRD3 Gene

  • Thioredoxin Reductase 3 2 3 4 5
  • TRXR3 2 3 4
  • TGR 2 3 4
  • Thioredoxin Reductase 3 Intronic Transcript 1 2 3
  • Thioredoxin And Glutathione Reductase 3 4
  • Thioredoxin Glutathione Reductase 2 3
  • Thioredoxin Reductase TR2 3 4
  • Selenoprotein TXNRD3 2 3
  • EC 1.8.1.9 4 50
  • TXNRD3NT1 2 3
  • TR2IT1 2 3
  • TR2 2 3
  • Thioredoxin Reductase 2 Intronic Transcript 1 3
  • Thioredoxin Reductase 3 Neighbor Gene Protein 3
  • Thioredoxin Reductase 3 New Transcript 1 3
  • Thioredoxin Reductase 3 Neighbor 2
  • TXNRD3 Neighbor Gene Protein 3
  • TXNRD3IT1 3
  • TXNRD3NB 3
  • EC 1.8.1 50
  • TXNRD3 5

External Ids for TXNRD3 Gene

Previous HGNC Symbols for TXNRD3 Gene

  • TXNRD3NB
  • TXNRD3IT1

Previous GeneCards Identifiers for TXNRD3 Gene

  • GC03M127607
  • GC03M127646
  • GC03M127808
  • GC03U901368
  • GC03M126327
  • GC03M123706
  • GC03M126292
  • GC03M126572
  • GC03M126573
  • GC03M126574
  • GC03M126575
  • GC03M126607

Summaries for TXNRD3 Gene

Entrez Gene Summary for TXNRD3 Gene

  • The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]

GeneCards Summary for TXNRD3 Gene

TXNRD3 (Thioredoxin Reductase 3) is a Protein Coding gene. Diseases associated with TXNRD3 include Amyloidosis, Familial Visceral and Neuroschistosomiasis. Among its related pathways are Gastric cancer and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is TXNRD1.

UniProtKB/Swiss-Prot Summary for TXNRD3 Gene

  • Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TXNRD3 Gene

Genomics for TXNRD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TXNRD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J126654 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 259.5 +0.4 423 2.2 BRCA1 POLR2A CHD2 MAX THAP11 REST KLF9 SMAD4 SP2 SAP130 TXNRD3 UROC1 CHST13 CHCHD6 LOC100419878 ENSG00000248557 C3orf22
GH03J126606 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 250.3 +47.7 47723 2.8 MAFF ZNF316 NFE2 MAFK MYC NFE2L2 MAFG BACH1 BHLHE40 DPF2 TXNRD3 piR-38779 HSALNG0028704 C3orf22
GH03J126522 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +128.0 128008 8.6 EZH2 ZNF600 SSRP1 ZMYM3 CEBPA ATF3 POLR2A ZIC2 YY1 MXD4 CHST13 TXNRD3 NUP210P1 OR7E29P C3orf22 ZXDC UROC1 HSALNG0028698
GH03J126679 Enhancer 0.9 ENCODE CraniofacialAtlas 11.6 -24.4 -24434 1.2 ZNF654 ZIC2 MXD4 CTCF REST TRIM22 BHLHE40 MAX ZNF217 SIN3A CHCHD6 TXNRD3 lnc-CHCHD6-1 HSALNG0028708
GH03J126620 Enhancer 0.6 Ensembl ENCODE 17.7 +35.3 35323 6.8 SPI1 JUND EP300 SCRT2 TXNRD3 NUP210P1 CHST13 HSALNG0028704 piR-38779 C3orf22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TXNRD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TXNRD3

Genomic Locations for TXNRD3 Gene

Latest Assembly
chr3:126,571,779-126,655,124
(GRCh38/hg38)
Size:
83,346 bases
Orientation:
Minus strand

Previous Assembly
chr3:126,325,893-126,373,967
(GRCh37/hg19 by Entrez Gene)
Size:
48,075 bases
Orientation:
Minus strand

chr3:126,290,622-126,373,998
(GRCh37/hg19 by Ensembl)
Size:
83,377 bases
Orientation:
Minus strand

Genomic View for TXNRD3 Gene

Genes around TXNRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNRD3 Gene

Proteins for TXNRD3 Gene

  • Protein details for TXNRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VQ6-TRXR3_HUMAN
    Recommended name:
    Thioredoxin reductase 3
    Protein Accession:
    Q86VQ6
    Secondary Accessions:
    • Q6PIS8
    • Q9NNW6
    • Q9P101

    Protein attributes for TXNRD3 Gene

    Size:
    643 amino acids
    Molecular mass:
    70683 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH30028.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAH30028.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=AAH50032.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAH50032.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};
    Miscellaneous:
    • The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for TXNRD3 Gene

neXtProt entry for TXNRD3 Gene

Selected DME Specific Peptides for TXNRD3 Gene

Q86VQ6:
  • NVPTTVFTPLEYG
  • IATGERPRYLGI
  • LGPNAGE
  • IGGGSGG
  • PGKTLVVGA
  • SDDLFSLPYCPG
  • TLVVGASYV
  • PTTVFTPLEYGCCGLSEE
  • CIPKKLMHQAALLG
  • CTRKIGLE
  • TTVFTPLE
  • GDKEYCI
  • FWPLEWT

Post-translational modifications for TXNRD3 Gene

  • Ubiquitination at Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNRD3 Gene

Domains & Families for TXNRD3 Gene

Gene Families for TXNRD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TXNRD3 Gene

InterPro:
Blocks:
  • Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
  • Glutaredoxin
  • Pyridine nucleotide-disulphide oxidoreductase, class I
  • FAD-dependent pyridine nucleotide reductase signature

Suggested Antigen Peptide Sequences for TXNRD3 Gene

GenScript: Design optimal peptide antigens:
  • Thioredoxin reductase 3 new transcript 1 (TR3N_HUMAN)
  • Thioredoxin reductase TR2 (TRXR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86VQ6

UniProtKB/Swiss-Prot:

TRXR3_HUMAN :
  • The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit of the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other subunit (By similarity).
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Domain:
  • The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit of the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other subunit (By similarity).
Family:
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
genes like me logo Genes that share domains with TXNRD3: view

Function for TXNRD3 Gene

Molecular function for TXNRD3 Gene

UniProtKB/Swiss-Prot Function:
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; Evidence={ECO:0000250|UniProtKB:Q99MD6};.

Enzyme Numbers (IUBMB) for TXNRD3 Gene

Phenotypes From GWAS Catalog for TXNRD3 Gene

Gene Ontology (GO) - Molecular Function for TXNRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004791 thioredoxin-disulfide reductase activity IEA,NAS 10455115
GO:0005515 protein binding IPI 32296183
GO:0009055 electron transfer activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with TXNRD3: view
genes like me logo Genes that share phenotypes with TXNRD3: view

Animal Models for research

  • Taconic Biosciences Mouse Models for TXNRD3

miRNA for TXNRD3 Gene

miRTarBase miRNAs that target TXNRD3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNRD3

Clone products for research

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNRD3 Gene

Localization for TXNRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNRD3 Gene

Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250 UniProtKB:Q99MD6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNRD3 gene
Compartment Confidence
mitochondrion 4
nucleus 4
endoplasmic reticulum 4
cytosol 4
extracellular 3
plasma membrane 1
cytoskeleton 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with TXNRD3: view

Pathways & Interactions for TXNRD3 Gene

genes like me logo Genes that share pathways with TXNRD3: view

Pathways by source for TXNRD3 Gene

1 GeneGo (Thomson Reuters) pathway for TXNRD3 Gene
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
1 Qiagen pathway for TXNRD3 Gene
  • Antioxidant Action of Vitamin-C

Interacting Proteins for TXNRD3 Gene

Gene Ontology (GO) - Biological Process for TXNRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0045454 cell redox homeostasis IEA,NAS 10455115
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TXNRD3: view

No data available for SIGNOR curated interactions for TXNRD3 Gene

Drugs & Compounds for TXNRD3 Gene

(8) Drugs for TXNRD3 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Selenium Approved, Investigational, Vet_approved Pharma 247
Water Approved Pharma 0
NADP Experimental Pharma 0
NADPH Experimental Pharma 0

(5) Additional Compounds for TXNRD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • H+
  • H(+)
  • Hydron
  • Hydrogen cation
  • Proton
Hydrogen selenide
  • Selenide
  • [SeH2]
  • H2Se
  • Hydroselenic acid
  • Hydroselenate
7783-07-5
Methaneselenol
  • Methylselenol
  • Methaneselenol
Methylselenic acid
  • Methylseleninate
  • Methylseleninic acid
  • Methylselenate
  • Methylselenic acid
  • Methaneseleninic acid
selenite
  • [SeO(OH)2]
  • Selenige saeure
  • Selenious acid
  • Acid, selenious
  • Acid, selenous
14124-67-5
genes like me logo Genes that share compounds with TXNRD3: view

Transcripts for TXNRD3 Gene

mRNA/cDNA for TXNRD3 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNRD3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TXNRD3 Gene

No ASD Table

Relevant External Links for TXNRD3 Gene

GeneLoc Exon Structure for
TXNRD3

Expression for TXNRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TXNRD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXNRD3 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for TXNRD3 Gene

This gene is overexpressed in Testis (41.8), Heart (12.0), and Plasma (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TXNRD3 Gene



Protein tissue co-expression partners for TXNRD3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TXNRD3

SOURCE GeneReport for Unigene cluster for TXNRD3 Gene:

Hs.477475
genes like me logo Genes that share expression patterns with TXNRD3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNRD3 Gene

Orthologs for TXNRD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNRD3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TXNRD3 29 30
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TXNRD3 29 30
  • 89.26 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Txnrd3 29 16 30
  • 82.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Txnrd3 29
  • 82.52 (n)
Cow
(Bos Taurus)
Mammalia TRXR3 30
  • 82 (a)
OneToOne
TXNRD3 29
  • 76.91 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TXNRD3 30
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TXNRD3 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TXNRD3 29 30
  • 75.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TXNRD3 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.618 29
Zebrafish
(Danio rerio)
Actinopterygii txnrd1 29 30
  • 67.17 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea trxr-1 29 30
  • 56.55 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLR1 30
  • 32 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 61 (a)
ManyToMany
CSA.8034 30
  • 60 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7635 29
Species where no ortholog for TXNRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TXNRD3 Gene

ENSEMBL:
Gene Tree for TXNRD3 (if available)
TreeFam:
Gene Tree for TXNRD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TXNRD3: view image
Alliance of Genome Resources:
Additional Orthologs for TXNRD3

Paralogs for TXNRD3 Gene

Paralogs for TXNRD3 Gene

(6) SIMAP similar genes for TXNRD3 Gene using alignment to 5 proteins:

  • TRXR3_HUMAN
  • E5RJ58_HUMAN
  • H0YBI6_HUMAN
  • H0YBQ0_HUMAN
  • L7N487_HUMAN
genes like me logo Genes that share paralogs with TXNRD3: view

Variants for TXNRD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TXNRD3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
770145 Benign: not provided 126,611,067(-) A/.
NM_052883.2(TXNRD3):c.1698= (p.Tyr566=)
NO_SEQUENCE_ALTERATION

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TXNRD3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TXNRD3 Gene

Variant ID Type Subtype PubMed ID
dgv126n6 CNV deletion 16902084
dgv2592n106 CNV deletion 24896259
dgv4852n100 CNV gain 25217958
dgv4852n100 CNV gain 25217958
esv1465418 CNV deletion 17803354
esv2005941 CNV deletion 18987734
esv2585777 CNV deletion 19546169
esv2725874 CNV deletion 23290073
esv2759 CNV loss 18987735
esv2834014 CNV deletion 24192839
esv3562508 CNV deletion 23714750
esv7947 CNV loss 19470904
esv987935 CNV deletion 20482838
esv987942 CNV deletion 20482838
nsv1072714 CNV deletion 25765185
nsv1144048 CNV deletion 24896259
nsv460842 CNV gain 19166990
nsv525296 CNV loss 19592680
nsv591524 CNV gain 21841781
nsv829717 CNV loss 17160897
nsv829718 CNV gain 17160897
nsv956828 CNV deletion 24416366

Variation tolerance for TXNRD3 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNRD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNRD3
Leiden Open Variation Database (LOVD)
TXNRD3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNRD3 Gene

Disorders for TXNRD3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TXNRD3 Gene - From: COP

Disorder Aliases PubMed IDs
amyloidosis, familial visceral
  • amyloidosis viii
neuroschistosomiasis
taeniasis
  • beef tapeworm infection
parasitic helminthiasis infectious disease
  • helminth infection
fascioliasis
  • fasciola hepatica infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TXNRD3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TXNRD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNRD3 Gene

Publications for TXNRD3 Gene

  1. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. (PMID: 10455115) Sun QA … Gladyshev VN (The Journal of biological chemistry 1999) 2 3 4 22
  2. CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. (PMID: 20018845) Gerashchenko MV … Gladyshev VN (The Journal of biological chemistry 2010) 3 4
  3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for TXNRD3 Gene

Sources for TXNRD3 Gene