Aliases for TXNRD2 Gene
External Ids for TXNRD2 Gene
Previous GeneCards Identifiers for TXNRD2 Gene
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
GeneCards Summary for TXNRD2 Gene
TXNRD2 (Thioredoxin Reductase 2) is a Protein Coding gene. Diseases associated with TXNRD2 include Glucocorticoid Deficiency 5 and Familial Glucocorticoid Deficiency. Among its related pathways are Detoxification of Reactive Oxygen Species and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is TXNRD3.
UniProtKB/Swiss-Prot Summary for TXNRD2 Gene
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.