The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encod... See more...

Aliases for TXNRD1 Gene

Aliases for TXNRD1 Gene

  • Thioredoxin Reductase 1 2 3 5
  • GRIM-12 2 3 4
  • Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein 3 4
  • Gene Associated With Retinoic And IFN-Induced Mortality 12 Protein 3 4
  • Thioredoxin Reductase 1, Cytoplasmic 3 4
  • KM-102-Derived Reductase-Like Factor 3 4
  • Thioredoxin Reductase TR1 3 4
  • EC 1.8.1.9 4 51
  • TXNR 2 3
  • TR 3 4
  • Testis Tissue Sperm-Binding Protein Li 46a 3
  • Thioredoxin Reductase GRIM-12 3
  • Oxidoreductase 3
  • EC 1.8.1 51
  • TXNRD1 5
  • GRIM12 4
  • TRXR1 3
  • Trxr1 2
  • KDRF 4
  • TR1 3

External Ids for TXNRD1 Gene

Previous GeneCards Identifiers for TXNRD1 Gene

  • GC12P103793
  • GC12P104561
  • GC12P104540
  • GC12P103183
  • GC12P103204
  • GC12P103133
  • GC12P101669
  • GC12P104609

Summaries for TXNRD1 Gene

Entrez Gene Summary for TXNRD1 Gene

  • The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]

GeneCards Summary for TXNRD1 Gene

TXNRD1 (Thioredoxin Reductase 1) is a Protein Coding gene. Diseases associated with TXNRD1 include Diphtheria and Exencephaly. Among its related pathways are Folate Metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is TXNRD3.

UniProtKB/Swiss-Prot Summary for TXNRD1 Gene

  • Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

Gene Wiki entry for TXNRD1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TXNRD1 Gene

Genomics for TXNRD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TXNRD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J104283 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.2 +72.5 72519 8.6 SP1 HNRNPL GATAD2A PRDM10 ZNF629 REST TFE3 RFX1 LEF1 NFKBIZ NONHSAG012141.2 TXNRD1 EID3 APPL2 TDG C12orf73 piR-38005-007
GH12J104215 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 605 +3.0 2958 7.1 CREB1 CTCF HNRNPL PRDM10 ZNF629 IKZF1 ZNF692 TARDBP JUND ETV6 TXNRD1 EID3 WASHC4 CHST11 hsa-miR-5095-100
GH12J104213 Enhancer 0.7 Ensembl ENCODE 600.7 -1.7 -1655 0.6 FOXA1 REST SP1 FOSL2 GATA3 BHLHE40 RCOR1 JUND CHD2 POLR2A TXNRD1 WASHC4 MF281438-007 NFYB
GH12J104279 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +65.1 65142 3.7 PRDM10 REST CEBPB SP1 HMBOX1 JUND BRCA1 NFE2 FOXA2 JUN ENSG00000257732 EID3 TXNRD1 GLT8D2 NONHSAG012141.2
GH12J104602 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.9 +389.4 389398 4.8 CREB1 RFX1 LEF1 IKZF1 ZNF692 JUND FOXA1 PRDM1 ZSCAN4 PKNOX1 CHST11 TDG WASHC4 TXNRD1 EID3 piR-46381-022 MIR3922 SLC41A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TXNRD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TXNRD1

Top Transcription factor binding sites by QIAGEN in the TXNRD1 gene promoter:
  • LCR-F1
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TXNRD1 Gene

Genomic Locations for TXNRD1 Gene
chr12:104,215,779-104,350,307
(GRCh38/hg38)
Size:
134,529 bases
Orientation:
Plus strand
chr12:104,609,557-104,744,062
(GRCh37/hg19)
Size:
134,506 bases
Orientation:
Plus strand

Genomic View for TXNRD1 Gene

Genes around TXNRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNRD1 Gene

Proteins for TXNRD1 Gene

  • Protein details for TXNRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16881-TRXR1_HUMAN
    Recommended name:
    Thioredoxin reductase 1, cytoplasmic
    Protein Accession:
    Q16881
    Secondary Accessions:
    • B7Z1F4
    • B7Z3Y8
    • B7Z904
    • E9PMY9
    • F5H780
    • Q6FI31
    • Q6VB40
    • Q6VB41
    • Q6VB42
    • Q6VBP2
    • Q6VBP3
    • Q6VBP4
    • Q6VBP5
    • Q6VBP9
    • Q6VBQ0
    • Q6YNQ1
    • Q76P53
    • Q7LA96
    • Q8WVC8
    • Q99475
    • Q9UES8
    • Q9UH79

    Protein attributes for TXNRD1 Gene

    Size:
    649 amino acids
    Molecular mass:
    70906 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.
    SequenceCaution:
    • Sequence=AAB35418.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAC69621.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAF15900.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAV38446.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAZ67916.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAA13674.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAH11490.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAH12374.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAH14140.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=CAA04503.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=CAA62629.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=CAG38744.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=EAW97745.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity.
    • [Isoform 1]: Minor isoform.
    • [Isoform 5]: Major isoform. The N-terminus of the sequence is processed into a mature form that lacks residues Met-151 and Asn-152 at the N-terminus.

    Three dimensional structures from OCA and Proteopedia for TXNRD1 Gene

    Alternative splice isoforms for TXNRD1 Gene

neXtProt entry for TXNRD1 Gene

Selected DME Specific Peptides for TXNRD1 Gene

Q16881:
  • NVPTTVFTPLEYG
  • IATGERPRYLGI
  • DSRNYGW
  • VGVKINEKTGKIPVT
  • IGGGSGGLAAAKEA
  • LGPNAGE
  • PSRDNNKCYAK
  • GSTVKCDY
  • IGGGSGG
  • QGFAAALK
  • PGKTLVVGA
  • ATNNKGKEK
  • GGGSGGLA
  • SDDLFSLPYCPG
  • EQIEAGTPGRL
  • CGLSEEKAVEKFGEEN
  • TLVVGASYV
  • DVTVMVRSILLRGFDQDMA
  • CIPKKLMHQAALLG
  • QLDSTIGIHPVCAE
  • CTRKIGLE
  • AGRLLAQRL
  • TTVFTPLE
  • HIGSLNWGYRVALREKKVVYENAYG
  • GDKEYCI
  • FWPLEWT

Post-translational modifications for TXNRD1 Gene

Antibody Products

  • Abcam antibodies for TXNRD1

Domains & Families for TXNRD1 Gene

Gene Families for TXNRD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TXNRD1 Gene

InterPro:
Blocks:
  • Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
  • Pyridine nucleotide-disulphide oxidoreductase, class I
  • FAD-dependent pyridine nucleotide reductase signature
ProtoNet:

Suggested Antigen Peptide Sequences for TXNRD1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA (B2R5P6_HUMAN)
  • cDNA FLJ56075, highly similar to Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (B7Z2S5_HUMAN)
  • cDNA FLJ56205, highly similar to Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (B7Z904_HUMAN)
  • Thioredoxin reductase TR1 (TRXR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16881

UniProtKB/Swiss-Prot:

TRXR1_HUMAN :
  • The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Domain:
  • The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.
Family:
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
genes like me logo Genes that share domains with TXNRD1: view

Function for TXNRD1 Gene

Molecular function for TXNRD1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;.
UniProtKB/Swiss-Prot Induction:
Isoform 5 is induced by a combination of interferon-beta and retinoic acid (at protein level). Isoform 1 is induced by estradiol or testosterone in HeLa cells.
GENATLAS Biochemistry:
thioredoxin reductase,pyridine nucleotide disulfide oxidoreductase family,ubiquitously expressed

Enzyme Numbers (IUBMB) for TXNRD1 Gene

Phenotypes From GWAS Catalog for TXNRD1 Gene

Gene Ontology (GO) - Molecular Function for TXNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004791 thioredoxin-disulfide reductase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 15199063
GO:0009055 electron transfer activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with TXNRD1: view
genes like me logo Genes that share phenotypes with TXNRD1: view

Animal Models for TXNRD1 Gene

MGI Knock Outs for TXNRD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNRD1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNRD1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXNRD1 Gene

Localization for TXNRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNRD1 Gene

Cytoplasm.
[Isoform 4]: Cytoplasm. Nucleus.
[Isoform 5]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNRD1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 4
plasma membrane 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TXNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TXNRD1: view

Pathways & Interactions for TXNRD1 Gene

genes like me logo Genes that share pathways with TXNRD1: view

Pathways by source for TXNRD1 Gene

1 GeneGo (Thomson Reuters) pathway for TXNRD1 Gene
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
1 Qiagen pathway for TXNRD1 Gene
  • Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for TXNRD1 Gene

Gene Ontology (GO) - Biological Process for TXNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA --
GO:0001887 selenium compound metabolic process TAS --
GO:0007165 signal transduction NAS 8921404
GO:0007369 gastrulation IEA --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with TXNRD1: view

No data available for SIGNOR curated interactions for TXNRD1 Gene

Drugs & Compounds for TXNRD1 Gene

(24) Drugs for TXNRD1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma Target, inhibitor 131
Selenium Approved, Investigational, Vet_approved Pharma Enzyme, substrate 227
FAD Approved Pharma Target 0
Vitamin C Approved Nutra Enzyme, substrate 748,748
Selenious acid Approved, Investigational Pharma Enzyme, substrate 16

(19) Additional Compounds for TXNRD1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
selenite
  • [seo(OH)2]
  • Selenige saeure
  • Selenious acid
  • Selenite
  • Acid, selenious
14124-67-5
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
Hydrogen selenide
  • [SeH2]
  • H2Se
  • Hydroselenic acid
  • Hydroselenate
  • Dihydrogen monoselenide
Methaneselenol
  • Methaneselenol
Methylselenic acid
  • Methylseleninate
  • Methylselenic acid
genes like me logo Genes that share compounds with TXNRD1: view

Transcripts for TXNRD1 Gene

mRNA/cDNA for TXNRD1 Gene

7 REFSEQ mRNAs :
56 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNRD1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNRD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7:
SP8: - - - - - - - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14: - - - -

ExUns: 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10: - - - - - - - - -
SP11:
SP12: - -
SP13:
SP14:

Relevant External Links for TXNRD1 Gene

GeneLoc Exon Structure for
TXNRD1

Expression for TXNRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TXNRD1 Gene

mRNA differential expression in normal tissues according to GTEx for TXNRD1 Gene

This gene is overexpressed in Adrenal Gland (x4.0).

Protein differential expression in normal tissues from HIPED for TXNRD1 Gene

This gene is overexpressed in Bone marrow stromal cell (9.5), Urinary Bladder (8.3), and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TXNRD1 Gene



Protein tissue co-expression partners for TXNRD1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TXNRD1

SOURCE GeneReport for Unigene cluster for TXNRD1 Gene:

Hs.654922

mRNA Expression by UniProt/SwissProt for TXNRD1 Gene:

Q16881-TRXR1_HUMAN
Tissue specificity: Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.

Evidence on tissue expression from TISSUES for TXNRD1 Gene

  • Nervous system(5)
  • Lung(4.9)
  • Liver(4.3)
  • Kidney(4.1)
  • Skin(4.1)
  • Intestine(3.2)
  • Heart(3.2)
  • Eye(3.1)
  • Blood(2.9)
  • Muscle(2.9)
  • Spleen(2.7)
  • Adrenal gland(2.6)
  • Thyroid gland(2.6)
  • Pancreas(2.5)
  • Stomach(2.5)
  • Bone marrow(2.4)
  • Lymph node(2.3)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with TXNRD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNRD1 Gene

Orthologs for TXNRD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNRD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TXNRD1 30 31
  • 99.73 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TXNRD1 31
  • 89 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TXNRD1 30 31
  • 88.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TXNRD1 30 31
  • 87.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Txnrd1 30
  • 85.44 (n)
Mouse
(Mus musculus)
Mammalia Txnrd1 30 17 31
  • 85.27 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TXNRD1 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TXNRD1 30 31
  • 79.09 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TXNRD1 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia txnrd1 30
  • 71.83 (n)
Zebrafish
(Danio rerio)
Actinopterygii -- 30
Fruit Fly
(Drosophila melanogaster)
Insecta Trxr-2 32
  • 51 (a)
Trxr-1 32
  • 50 (a)
Worm
(Caenorhabditis elegans)
Secernentea C06G3.7 32
  • 58 (a)
trxr-1 31
  • 48 (a)
OneToMany
ZK637.10 32
  • 44 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLR1 31
  • 34 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons GR1 30
  • 49.28 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0813500 30
  • 46.57 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 66 (a)
ManyToMany
CSA.8034 31
  • 59 (a)
ManyToMany
Species where no ortholog for TXNRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TXNRD1 Gene

ENSEMBL:
Gene Tree for TXNRD1 (if available)
TreeFam:
Gene Tree for TXNRD1 (if available)

Paralogs for TXNRD1 Gene

Paralogs for TXNRD1 Gene

(7) SIMAP similar genes for TXNRD1 Gene using alignment to 15 proteins:

  • TRXR1_HUMAN
  • B2R5P6_HUMAN
  • B7Z2S5_HUMAN
  • E2QRB9_HUMAN
  • E7ESI6_HUMAN
  • E7EW10_HUMAN
  • E9PIR7_HUMAN
  • E9PIZ5_HUMAN
  • E9PJU2_HUMAN
  • E9PKD3_HUMAN
  • E9PKI4_HUMAN
  • E9PLT3_HUMAN
  • E9PNQ6_HUMAN
  • E9PQI3_HUMAN
  • E9PRI8_HUMAN
genes like me logo Genes that share paralogs with TXNRD1: view

Variants for TXNRD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TXNRD1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
709457 Likely Benign: not provided 104,288,936(+) G/A MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
712609 Benign: not provided 104,326,379(+) A/G SYNONYMOUS_VARIANT
724046 Likely Benign: not provided 104,313,269(+) G/A MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
725773 Likely Benign: not provided 104,251,602(+) G/C MISSENSE_VARIANT
727044 Likely Benign: not provided 104,321,084(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TXNRD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TXNRD1 Gene

Variant ID Type Subtype PubMed ID
dgv301e214 CNV loss 21293372
esv1648435 CNV deletion 17803354
esv23043 CNV loss 19812545
esv2658616 CNV deletion 23128226
esv2659315 CNV deletion 23128226
esv3549721 CNV deletion 23714750
esv3580447 CNV loss 25503493
esv3580448 CNV loss 25503493
esv3630630 CNV loss 21293372
esv3630631 CNV loss 21293372
esv3630632 CNV gain 21293372
esv3630633 CNV loss 21293372
esv3630634 CNV gain 21293372
esv3630636 CNV loss 21293372
nsv1138165 CNV deletion 24896259
nsv1144645 CNV deletion 24896259
nsv1145619 CNV deletion 24896259
nsv52994 CNV deletion 16902084
nsv819204 CNV gain 19587683
nsv930479 CNV deletion 23359205
nsv983360 CNV duplication 23825009

Variation tolerance for TXNRD1 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNRD1 Gene

Human Gene Mutation Database (HGMD)
TXNRD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNRD1 Gene

Disorders for TXNRD1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TXNRD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diphtheria
  • corynebacterium infection
exencephaly
keshan disease
  • caused by deficiency of selenium in the diet
asbestos-related lung carcinoma
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TXNRD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TXNRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNRD1 Gene

Publications for TXNRD1 Gene

  1. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. (PMID: 19896490) Engström KS … Broberg K (Mutation research 2010) 3 23 41
  2. Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset. (PMID: 18996185) Mitchell J … de Belleroche J (Free radical biology & medicine 2009) 3 23 41
  3. Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1. (PMID: 18042542) Dammeyer P … Arnér ES (The Journal of biological chemistry 2008) 3 4 23
  4. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. (PMID: 18483336) Peters U … Foster CB (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23 41
  5. The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis. (PMID: 17512005) Fritz-Wolf K … Becker K (Journal of molecular biology 2007) 3 4 23

Products for TXNRD1 Gene

Sources for TXNRD1 Gene