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This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress.... See more...
Aliases for TXNIP Gene
Aliases for TXNIP Gene
External Ids for TXNIP Gene
- HGNC: 16952
- Entrez Gene: 10628
- Ensembl: ENSG00000265972
- OMIM: 606599
- UniProtKB: Q9H3M7
Previous GeneCards Identifiers for TXNIP Gene
- GC01P143959
- GC01P142025
- GC01P143165
- GC01P143187
- GC01P142927
- GC01P144149
- GC01P145438
- GC01P119402
Summaries for TXNIP Gene
-
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for TXNIP Gene
TXNIP (Thioredoxin Interacting Protein) is a Protein Coding gene. Diseases associated with TXNIP include Hyperglycemia and Hyperlipidemia, Familial Combined, 3. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and enzyme inhibitor activity. An important paralog of this gene is ARRDC4.
UniProtKB/Swiss-Prot Summary for TXNIP Gene
-
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Additional gene information for TXNIP Gene
- HGNC(16952)
- Entrez Gene(10628)
- Ensembl(ENSG00000265972)
- OMIM(606599)
- UniProtKB(Q9H3M7)
- Open Targets Platform(ENSG00000265972)
- Monarch Initiative
- Search for TXNIP at DataMed
- Search for TXNIP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TXNIP Gene
Genomics for TXNIP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TXNIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TXNIP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TXNIP
- Top Transcription factor binding sites by QIAGEN in the TXNIP gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- p53
- PPAR-gamma1
- PPAR-gamma2
- ZIC2
Genomic Locations for TXNIP Gene
Genomic Locations for TXNIP Gene
- chr1:145,992,435-145,996,579
- (GRCh38/hg38)
- Size:
- 4,145 bases
- Orientation:
- Minus strand
- chr1:145,438,462-145,442,635
- (GRCh37/hg19)
- Size:
- 4,174 bases
- Orientation:
- Plus strand
Genomic View for TXNIP Gene
Genes around TXNIP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.1 by HGNC
- 1q21.1 by Entrez Gene
- 1q21.1 by Ensembl
TXNIP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TXNIP Gene
Proteins for TXNIP Gene
-
Protein details for TXNIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H3M7-TXNIP_HUMAN
- Recommended name:
- Thioredoxin-interacting protein
- Protein Accession:
- Q9H3M7
- B4E3D3
- Q16226
- Q6PML0
- Q9BXG9
Protein attributes for TXNIP Gene
- Size:
- 391 amino acids
- Molecular mass:
- 43661 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.
Three dimensional structures from OCA and Proteopedia for TXNIP Gene
Protein Expression for TXNIP Gene
Post-translational modifications for TXNIP Gene
- Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
-
Ubiquitination at Lys26, Lys212, Lys228, Lys233, and Lys287
- NX_Q9H3M7 (NX_Q9H3M7-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TXNIP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TXNIP Antibody (LS-B5829) and TXNIP Antibody (LS-B12126)
- G Biosciences Immunotag™ TXNIP Antibody
- Creative Diagnostics Anti-TXNIP monoclonal antibody
- Novus Biologicals Antibodies for TXNIP
-
Abcam antibodies for TXNIP
- Invitrogen Antibodies for TXNIP (AFLGC-TXNIP)
- antibodies-online: Show 29 available TXNIP Antibodies ranked by validation data
- Compare Top TXNIP Antibodies
-
Recommended
- 72 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 56 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for TXNIP
-
Santa Cruz Biotechnology (SCBT) Antibodies for TXNIP
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TXNIP
- Origene Custom Protein Services for TXNIP
-
Abcam proteins for TXNIP
Assay Products
- Novus Biologicals ELISA Kits for TXNIP
- antibodies-online: Show 45 available TXNIP Elisa Kits ranked by validation data
- Compare Top TXNIP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TXNIP Gene
Domains & Families for TXNIP Gene
Gene Families for TXNIP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for TXNIP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TXNIP Gene
- GenScript: Design optimal peptide antigens:
-
- Thioredoxin interacting protein (B1ALI9_HUMAN)
- Vitamin D3 up-regulated protein 1 (TXNIP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H3M7- Family:
-
- Belongs to the arrestin family.
Function for TXNIP Gene
Molecular function for TXNIP Gene
- UniProtKB/Swiss-Prot Function:
- May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
- UniProtKB/Swiss-Prot Induction:
- By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress.
Phenotypes From GWAS Catalog for TXNIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004857 | enzyme inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 10814541 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 20068034 |
Phenotypes for TXNIP Gene
- MGI mutant phenotypes for TXNIP:
-
inferred from 9 alleles
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for TXNIP:
Animal Models for TXNIP Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TXNIP - Select products 50% OFF >
- * TXNIP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TXNIP
-
Santa Cruz Biotechnology (SCBT) CRISPR for TXNIP
miRNA for TXNIP Gene
- miRTarBase miRNAs that target TXNIP
-
- hsa-miR-373-3p (MIRT005561)
- mmu-miR-301b-3p (MIRT007880)
- mmu-miR-15a-5p (MIRT011744)
- mmu-miR-19b-3p (MIRT012452)
- mmu-miR-149-5p (MIRT014600)
- hsa-miR-148b-3p (MIRT019486)
- hsa-miR-128-3p (MIRT022063)
- hsa-miR-183-5p (MIRT025014)
- hsa-miR-34a-5p (MIRT025554)
- hsa-miR-378a-3p (MIRT043886)
- hsa-miR-372-3p (MIRT054148)
- rno-miR-17-5p (MIRT054383)
- hsa-miR-27a-3p (MIRT059144)
- hsa-miR-216a-3p (MIRT059145)
- hsa-miR-224-5p (MIRT059146)
- hsa-miR-27b-3p (MIRT059147)
- hsa-miR-335-5p (MIRT059148)
- hsa-miR-660-3p (MIRT059151)
- hsa-miR-3189-3p (MIRT059152)
- hsa-miR-4326 (MIRT059153)
- hsa-miR-3681-3p (MIRT059154)
- hsa-miR-3940-5p (MIRT059155)
- hsa-miR-4507 (MIRT059156)
- hsa-miR-4691-5p (MIRT059157)
- hsa-miR-5193 (MIRT059158)
- hsa-miR-6749-3p (MIRT059159)
- hsa-miR-6792-3p (MIRT059161)
- hsa-miR-6839-3p (MIRT059162)
- hsa-miR-16-1-3p (MIRT059163)
- hsa-miR-152-5p (MIRT059164)
- hsa-miR-4443 (MIRT059165)
- hsa-miR-3689d (MIRT059166)
- hsa-miR-6515-5p (MIRT059167)
- hsa-miR-6768-5p (MIRT059168)
- hsa-miR-6851-5p (MIRT059169)
- hsa-miR-17-5p (MIRT130067)
- hsa-miR-20a-5p (MIRT130070)
- hsa-miR-93-5p (MIRT130073)
- hsa-miR-106a-5p (MIRT130075)
- hsa-miR-148a-3p (MIRT130076)
- hsa-miR-204-5p (MIRT130078)
- hsa-miR-211-5p (MIRT130079)
- hsa-miR-130a-3p (MIRT130081)
- hsa-miR-135a-5p (MIRT130082)
- hsa-miR-152-3p (MIRT130085)
- hsa-miR-186-3p (MIRT130089)
- hsa-miR-106b-5p (MIRT130091)
- hsa-miR-302a-3p (MIRT130093)
- hsa-miR-34c-5p (MIRT130094)
- hsa-miR-301a-3p (MIRT130095)
- hsa-miR-130b-3p (MIRT130097)
- hsa-miR-302b-3p (MIRT130098)
- hsa-miR-302c-3p (MIRT130099)
- hsa-miR-302d-3p (MIRT130100)
- hsa-miR-135b-5p (MIRT130101)
- hsa-miR-20b-5p (MIRT130105)
- hsa-miR-449a (MIRT130106)
- hsa-miR-520e (MIRT130113)
- hsa-miR-520a-3p (MIRT130117)
- hsa-miR-526b-3p (MIRT130118)
- hsa-miR-520b (MIRT130120)
- hsa-miR-520c-3p (MIRT130121)
- hsa-miR-519d-5p (MIRT130123)
- hsa-miR-519d-3p (MIRT130124)
- hsa-miR-520d-3p (MIRT130125)
- hsa-miR-520g-3p (MIRT130126)
- hsa-miR-520h (MIRT130128)
- hsa-miR-499a-3p (MIRT130131)
- hsa-miR-561-3p (MIRT130135)
- hsa-miR-548b-3p (MIRT130137)
- hsa-miR-588 (MIRT130138)
- hsa-miR-623 (MIRT130143)
- hsa-miR-449b-5p (MIRT130146)
- hsa-miR-454-3p (MIRT130148)
- hsa-miR-889-5p (MIRT130149)
- hsa-miR-873-5p (MIRT130150)
- hsa-miR-301b-3p (MIRT130152)
- hsa-miR-302e (MIRT130159)
- hsa-miR-2116-3p (MIRT130162)
- hsa-miR-3119 (MIRT130164)
- hsa-miR-548t-3p (MIRT130165)
- hsa-miR-4295 (MIRT130171)
- hsa-miR-3666 (MIRT130176)
- hsa-miR-548aa (MIRT130181)
- hsa-miR-4446-5p (MIRT130186)
- hsa-miR-4639-5p (MIRT130192)
- hsa-miR-4701-5p (MIRT130193)
- hsa-miR-4709-3p (MIRT130194)
- hsa-miR-4755-5p (MIRT130197)
- hsa-miR-499b-3p (MIRT130199)
- hsa-miR-5006-3p (MIRT130203)
- hsa-miR-548ap-3p (MIRT130205)
- hsa-miR-5196-3p (MIRT130206)
- hsa-miR-548au-3p (MIRT130215)
- hsa-miR-6721-5p (MIRT130221)
- hsa-miR-6826-5p (MIRT130231)
- hsa-miR-6832-3p (MIRT130232)
- hsa-miR-6516-5p (MIRT130236)
- hsa-miR-8060 (MIRT130241)
- hsa-miR-8083 (MIRT130244)
- hsa-miR-3179 (MIRT180535)
- hsa-miR-194-3p (MIRT180544)
- hsa-miR-3929 (MIRT180547)
- hsa-miR-4478 (MIRT180548)
- hsa-miR-4419b (MIRT180549)
- hsa-miR-4708-3p (MIRT180551)
- hsa-miR-6809-5p (MIRT180552)
- hsa-miR-17-3p (MIRT180553)
- hsa-miR-512-3p (MIRT180554)
- hsa-miR-885-3p (MIRT180555)
- hsa-miR-6734-5p (MIRT180559)
- hsa-miR-6868-5p (MIRT180560)
- hsa-miR-134-5p (MIRT246172)
- hsa-miR-363-5p (MIRT246174)
- hsa-miR-423-5p (MIRT246175)
- hsa-miR-1236-5p (MIRT246177)
- hsa-miR-3118 (MIRT246178)
- hsa-miR-3136-5p (MIRT246179)
- hsa-miR-3184-5p (MIRT246181)
- hsa-miR-3670 (MIRT246182)
- hsa-miR-4436a (MIRT246185)
- hsa-miR-4439 (MIRT246186)
- hsa-miR-4513 (MIRT246187)
- hsa-miR-4693-3p (MIRT246188)
- hsa-miR-4700-3p (MIRT246189)
- hsa-miR-5000-3p (MIRT246190)
- hsa-miR-5586-3p (MIRT246191)
- hsa-miR-5691 (MIRT246192)
- hsa-miR-6745 (MIRT246194)
- hsa-miR-6761-5p (MIRT246195)
- hsa-miR-6762-5p (MIRT246196)
- hsa-miR-6805-3p (MIRT246197)
- hsa-miR-6845-5p (MIRT246198)
- hsa-miR-6854-5p (MIRT246199)
- hsa-miR-6855-3p (MIRT246200)
- hsa-miR-6874-5p (MIRT246201)
- hsa-miR-6880-5p (MIRT246202)
- hsa-miR-4476 (MIRT266189)
- hsa-miR-3975 (MIRT266191)
- hsa-miR-6876-5p (MIRT266192)
- hsa-miR-101-5p (MIRT266193)
- hsa-miR-1273d (MIRT266194)
- hsa-miR-2054 (MIRT266198)
- hsa-miR-6888-5p (MIRT332866)
- hsa-miR-2861 (MIRT332871)
- hsa-miR-1298-3p (MIRT332886)
- hsa-miR-3126-3p (MIRT332889)
- hsa-miR-3202 (MIRT464906)
- hsa-miR-4290 (MIRT464907)
- hsa-miR-18a-3p (MIRT464908)
- hsa-miR-6732-5p (MIRT464909)
- hsa-miR-3158-3p (MIRT464910)
- hsa-miR-7843-5p (MIRT464911)
- hsa-miR-6879-5p (MIRT464912)
- hsa-miR-6735-5p (MIRT464913)
- hsa-miR-4632-5p (MIRT464914)
- hsa-miR-4436b-3p (MIRT464915)
- hsa-miR-155-3p (MIRT464916)
- hsa-miR-4800-5p (MIRT464917)
- hsa-miR-8071 (MIRT464918)
- hsa-miR-711 (MIRT464919)
- hsa-miR-7114-3p (MIRT464920)
- hsa-miR-1180-5p (MIRT464921)
- hsa-miR-4257 (MIRT464922)
- hsa-miR-6847-5p (MIRT464923)
- hsa-miR-4735-3p (MIRT464924)
- hsa-miR-323a-3p (MIRT464925)
- hsa-miR-18b-5p (MIRT464926)
- hsa-miR-18a-5p (MIRT464927)
- hsa-miR-4687-3p (MIRT500612)
- hsa-miR-7974 (MIRT500613)
- hsa-miR-6500-5p (MIRT500614)
- hsa-miR-4633-3p (MIRT500615)
- hsa-miR-1537-5p (MIRT500616)
- hsa-miR-3194-3p (MIRT500617)
- hsa-miR-6504-5p (MIRT500618)
- hsa-miR-3064-5p (MIRT500619)
- hsa-miR-4330 (MIRT500620)
- hsa-miR-618 (MIRT500621)
- hsa-miR-1202 (MIRT500622)
- hsa-miR-5580-5p (MIRT500623)
- hsa-miR-31-3p (MIRT500624)
- hsa-miR-6499-3p (MIRT500625)
- hsa-miR-6738-5p (MIRT500626)
- hsa-miR-5194 (MIRT500627)
- hsa-miR-1914-3p (MIRT500628)
- hsa-miR-6857-3p (MIRT500629)
- hsa-miR-642b-3p (MIRT500630)
- hsa-miR-642a-3p (MIRT500631)
- hsa-miR-455-3p (MIRT500632)
- hsa-miR-4666a-5p (MIRT500633)
- hsa-miR-4539 (MIRT505260)
- hsa-miR-5002-5p (MIRT505261)
- hsa-miR-573 (MIRT505262)
- hsa-miR-3616-5p (MIRT505263)
- hsa-miR-629-5p (MIRT505264)
- hsa-miR-2277-3p (MIRT505265)
- hsa-miR-4304 (MIRT505266)
- hsa-miR-212-5p (MIRT505267)
- hsa-miR-29b-1-5p (MIRT533396)
- hsa-miR-3187-3p (MIRT533397)
- hsa-miR-4435 (MIRT533398)
- hsa-miR-548s (MIRT533399)
- hsa-miR-4511 (MIRT561375)
- hsa-miR-4796-3p (MIRT561376)
- hsa-miR-3609 (MIRT561377)
- hsa-miR-548ah-5p (MIRT561378)
- hsa-miR-4682 (MIRT565128)
- hsa-miR-3065-5p (MIRT565129)
- hsa-miR-5688 (MIRT565130)
- hsa-miR-495-3p (MIRT565131)
- hsa-miR-6771-3p (MIRT565132)
- hsa-miR-514b-3p (MIRT571580)
- hsa-miR-514a-3p (MIRT571581)
- rno-miR-20a-5p (MIRT732958)
- mmu-miR-17-3p (MIRT733385)
- hsa-miR-130a-5p (MIRT762495)
- hsa-miR-15a-5p (MIRT762927)
- hsa-miR-15b-5p (MIRT762936)
- hsa-miR-16-5p (MIRT762944)
- hsa-miR-195-5p (MIRT763479)
- hsa-miR-23a-3p (MIRT764012)
- hsa-miR-23b-3p (MIRT764030)
- hsa-miR-23c (MIRT764048)
- hsa-miR-298 (MIRT764373)
- hsa-miR-3154 (MIRT765057)
- hsa-miR-3175 (MIRT765244)
- hsa-miR-424-5p (MIRT767959)
- hsa-miR-4426 (MIRT768885)
- hsa-miR-4647 (MIRT770603)
- hsa-miR-4662b (MIRT770809)
- hsa-miR-4717-3p (MIRT771425)
- hsa-miR-497-5p (MIRT772810)
- hsa-miR-6838-5p (MIRT780094)
- hsa-miR-6878-5p (MIRT780778)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TXNIP
- Browse OriGene Inhibitory RNA Products For TXNIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNIP
Clone Products
- Applied Biological Materials (abm): Clones for TXNIP - Select products 50% OFF >
- * TXNIP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206196
- MG206284
- MG227021
- MR206196
- MR206196L3
- MR206196L4
- MR206284
- MR206284L3
- MR206284L4
- MR227021
- MR227021L3
- MR227021L4
- RC210804
- RC210804L1
- RC210804L2
- RC210804L3
- RC210804L4
- RG210804
- RR208024
- RR208024L3
- RR208024L4
- MR206196L3V
- MR206196L4V
- MR206284L3V
- MR206284L4V
- MR227021L3V
- MR227021L4V
- RC210804L1V
- RC210804L2V
- RC210804L3V
- RC210804L4V
- RR208024L3V
- RR208024L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TXNIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TXNIP
Cell Line Products
-
Horizon Cell Lines for TXNIP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXNIP Gene
Localization for TXNIP Gene
Subcellular locations from UniProtKB/Swiss-Prot for TXNIP Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 4 |
| nucleus | 4 |
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 14632196 |
| GO:0005758 | mitochondrial intermembrane space | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for TXNIP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
.01
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Glucose / Energy Metabolism | ||
| 4 | NOD-like receptor signaling pathway | ||
Pathways by source for TXNIP Gene
5 Reactome pathways for TXNIP Gene
1 KEGG pathway for TXNIP Gene
1 Cell Signaling Technology pathway for TXNIP Gene
Interacting Proteins for TXNIP Gene
Selected Interacting proteins:
Q9H3M7-TXNIP_HUMAN
ENSP00000462521
for TXNIP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TXNIP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006606 | protein import into nucleus | IEA | -- |
| GO:0006979 | response to oxidative stress | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0009612 | response to mechanical stimulus | IEA | -- |
Transcripts for TXNIP Gene
mRNA/cDNA for TXNIP Gene
- 2 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000425134 1225 nts (view in UCSC)
- ENST00000486597 509 nts (view in UCSC)
- ENST00000488537 1509 nts (view in UCSC)
- ENST00000582401 2905 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TXNIP - Select products 50% OFF >
- * TXNIP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TXNIP
-
Santa Cruz Biotechnology (SCBT) CRISPR for TXNIP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TXNIP
- Browse OriGene Inhibitory RNA Products For TXNIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNIP
Clone Products
- Applied Biological Materials (abm): Clones for TXNIP - Select products 50% OFF >
- * TXNIP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206196
- MG206284
- MG227021
- MR206196
- MR206196L3
- MR206196L4
- MR206284
- MR206284L3
- MR206284L4
- MR227021
- MR227021L3
- MR227021L4
- RC210804
- RC210804L1
- RC210804L2
- RC210804L3
- RC210804L4
- RG210804
- RR208024
- RR208024L3
- RR208024L4
- MR206196L3V
- MR206196L4V
- MR206284L3V
- MR206284L4V
- MR227021L3V
- MR227021L4V
- RC210804L1V
- RC210804L2V
- RC210804L3V
- RC210804L4V
- RR208024L3V
- RR208024L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TXNIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TXNIP
Relevant External Links for TXNIP Gene
- GeneLoc Exon Structure for
- TXNIP
Expression for TXNIP Gene
This gene is overexpressed in Breast (63.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TXNIP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TXNIP
SOURCE GeneReport for Unigene cluster for TXNIP Gene:
Hs.709057Evidence on tissue expression from TISSUES for TXNIP Gene
- Nervous system(5)
- Intestine(4.9)
- Blood(4.9)
- Lung(4.8)
- Eye(4.8)
- Spleen(4.7)
- Kidney(4.7)
- Pancreas(4.5)
- Heart(4.5)
- Muscle(4.4)
- Stomach(4.3)
- Liver(4)
- Skin(3.6)
- Lymph node(3.4)
- Bone marrow(3.1)
- Thyroid gland(3.1)
- Adrenal gland(3)
- Bone(2.9)
- Gall bladder(2.4)
Primer Products
-
OriGene qPCR primer pairs for TXNIP
-
OriGene qPCR primer pairs and template standards for TXNIP
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNIP Gene
Orthologs for TXNIP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TXNIP 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | TXNIP 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | TXNIP 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Txnip 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Txnip 30 17 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | txnip 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.27568 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | txnipa 30 |
|
||
| txnip 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4823 30 |
|
- Species where no ortholog for TXNIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TXNIP Gene
- ENSEMBL:
- Gene Tree for TXNIP (if available)
- TreeFam:
- Gene Tree for TXNIP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TXNIP: view image
Paralogs for TXNIP Gene
Variants for TXNIP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TXNIP Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 726040 | Benign: not provided | 145,994,148(-) | A/G | SYNONYMOUS_VARIANT | |
| 726271 | Benign: not provided | 145,994,128(-) | C/T | MISSENSE_VARIANT | |
| 775596 | Benign: not provided | 145,994,685(-) | C/A | SYNONYMOUS_VARIANT | |
| 777922 | Benign: not provided | 145,994,078(-) | C/T | MISSENSE_VARIANT | |
| rs6674773 | - | p.Arg177Gln |
Residual Variation Intolerance Score:
25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.09;
38.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TXNIP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TXNIP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNIP Gene
Disorders for TXNIP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyperglycemia |
|
|
| hyperlipidemia, familial combined, 3 |
|
|
| exocervical carcinoma |
|
|
| diabetes mellitus |
|
|
| diabetes mellitus, noninsulin-dependent |
|
Search TXNIP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TXNIP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TXNIP Gene
Publications for TXNIP Gene
- Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. (PMID: 8086474) Chen KS … DeLuca HF (Biochimica et biophysica acta 1994) 2 3 4 23
- The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. (PMID: 20068034) Zhang P … Yu L (The Journal of biological chemistry 2010) 3 4 23
- hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. (PMID: 18541147) Shin KH … Park NH (Biochemical and biophysical research communications 2008) 3 4 23
- Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). (PMID: 17603038) Liyanage NP … Lou MF (Experimental eye research 2007) 3 4 23
- Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus. (PMID: 17381501) van Greevenbroek MM … de Bruin TW (Diabetic medicine : a journal of the British Diabetic Association 2007) 3 23 41
ExternalLinks
Products for TXNIP Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TXNIP
- Origene Custom Protein Services for TXNIP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TXNIP
- Browse OriGene Inhibitory RNA Products For TXNIP
- OriGene qPCR primer pairs for TXNIP
- OriGene qPCR primer pairs and template standards for TXNIP
- MG206196
- MG206284
- MG227021
- MR206196
- MR206196L3
- MR206196L4
- MR206284
- MR206284L3
- MR206284L4
- MR227021
- MR227021L3
- MR227021L4
- RC210804
- RC210804L1
- RC210804L2
- RC210804L3
- RC210804L4
- RG210804
- RR208024
- RR208024L3
- RR208024L4
- MR206196L3V
- MR206196L4V
- MR206284L3V
- MR206284L4V
- MR227021L3V
- MR227021L4V
- RC210804L1V
- RC210804L2V
- RC210804L3V
- RC210804L4V
- RR208024L3V
- RR208024L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TXNIP
- Sino Biological Human cDNA Clone for TXNIP
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TXNIP
- Novus Biologicals proteins and lysates for TXNIP
- Novus Biologicals ELISA Kits for TXNIP
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TXNIP
- Abcam proteins for TXNIP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for TXNIP (AFLGC-TXNIP)
- VectorBuilder Custom and pre-made DNA vectors for TXNIP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TXNIP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TXNIP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TXNIP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TXNIP
- antibodies-online: Show 29 available TXNIP Antibodies ranked by validation data
- Compare Top TXNIP Antibodies
- Recommended
- 72 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 56 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 45 available TXNIP Elisa Kits ranked by validation data
- Compare Top TXNIP Elisa Kits
- Quality Products:
- antibodies-online: Show 9 available TXNIP Proteins ranked by validation data
- Compare Top TXNIP Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TXNIP
- Search Santa Cruz Biotechnology (SCBT) for TXNIP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TXNIP
- Custom Antibody ServicesProSci Antibodies for TXNIP
- Search for TXNIP Proteins at ProSci
- Horizon Cell Lines for TXNIP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TXNIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TXNIP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TXNIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNIP
Sources for TXNIP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42)