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This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
TXNIP (Thioredoxin Interacting Protein) is a Protein Coding gene. Diseases associated with TXNIP include Hyperglycemia and Hyperlipidemia, Familial Combined, 3. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and enzyme inhibitor activity. An important paralog of this gene is ARRDC4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004857 | enzyme inhibitor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 10814541 |
GO:0031625 | ubiquitin protein ligase binding | IPI | 20068034 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 14632196 |
GO:0005758 | mitochondrial intermembrane space | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
.01
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2 | Innate Immune System |
.61
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3 | Glucose / Energy Metabolism | ||
4 | NOD-like receptor signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006606 | protein import into nucleus | IEA | -- |
GO:0006979 | response to oxidative stress | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0009612 | response to mechanical stimulus | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TXNIP 30 |
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Dog (Canis familiaris) |
Mammalia | TXNIP 30 |
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Cow (Bos Taurus) |
Mammalia | TXNIP 30 |
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Rat (Rattus norvegicus) |
Mammalia | Txnip 30 |
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Mouse (Mus musculus) |
Mammalia | Txnip 30 17 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | txnip 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | Xl.27568 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | txnipa 30 |
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txnip 30 |
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Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4823 30 |
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SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
726040 | Benign: not provided | 145,994,148(-) | A/G | SYNONYMOUS_VARIANT | |
726271 | Benign: not provided | 145,994,128(-) | C/T | MISSENSE_VARIANT | |
775596 | Benign: not provided | 145,994,685(-) | C/A | SYNONYMOUS_VARIANT | |
777922 | Benign: not provided | 145,994,078(-) | C/T | MISSENSE_VARIANT | |
rs6674773 | - | p.Arg177Gln |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperglycemia |
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hyperlipidemia, familial combined, 3 |
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exocervical carcinoma |
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diabetes mellitus |
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diabetes mellitus, noninsulin-dependent |
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