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Aliases for TXNDC5 Gene

Aliases for TXNDC5 Gene

  • Thioredoxin Domain Containing 5 2 3 5
  • Protein Disulfide Isomerase Family A, Member 15 2 3
  • Endoplasmic Reticulum Resident Protein 46 3 4
  • Thioredoxin-Like Protein P46 3 4
  • ER Protein 46 3 4
  • ERP46 3 4
  • Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) 3
  • Endothelial Protein Disulphide Isomerase 3
  • Thioredoxin Domain-Containing Protein 5 3
  • Endoplasmic Reticulum Protein ERp46 3
  • Thioredoxin Related Protein 3
  • PDIA15 3
  • UNQ364 3
  • HCC-2 3
  • STRF8 3
  • TLP46 4
  • HCC2 3

External Ids for TXNDC5 Gene

Previous GeneCards Identifiers for TXNDC5 Gene

  • GC06M007871
  • GC06M007826

Summaries for TXNDC5 Gene

Entrez Gene Summary for TXNDC5 Gene

  • This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

GeneCards Summary for TXNDC5 Gene

TXNDC5 (Thioredoxin Domain Containing 5) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Innate Immune System. Gene Ontology (GO) annotations related to this gene include isomerase activity and protein disulfide isomerase activity. An important paralog of this gene is DNAJC10.

UniProtKB/Swiss-Prot for TXNDC5 Gene

  • Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).

Gene Wiki entry for TXNDC5 Gene

Additional gene information for TXNDC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC5 Gene

Genomics for TXNDC5 Gene

GeneHancer (GH) Regulatory Elements for TXNDC5 Gene

Promoters and enhancers for TXNDC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I007908 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 566.8 +0.5 508 3.4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SP3 TXNDC5 BMP6 BLOC1S5 LOC100506207 GC06P007902 BLOC1S5-TXNDC5
GH06I007907 Promoter/Enhancer 0.9 EPDnew Ensembl dbSUPER 563.7 +3.1 3113 1 TXNDC5 GC06P007902 BLOC1S5-TXNDC5
GH06I007912 Enhancer 0.9 ENCODE dbSUPER 550.8 -1.5 -1469 0.2 SOX13 SAP130 MAX CEBPG ZNF644 RAD21 RARA YY1 RELA ATF7 TXNDC5 BMP6 BLOC1S5 GC06P007902 GC06M007933 BLOC1S5-TXNDC5
GH06I007899 Enhancer 1.1 ENCODE dbSUPER 15.4 +11.1 11100 1 ATF1 PKNOX1 SMAD1 ARNT YY1 TCF12 GATA2 ARID2 ATF7 RXRA TXNDC5 BLOC1S5 GC06P007902 PIR41509 BLOC1S5-TXNDC5
GH06I007882 Enhancer 0.9 ENCODE dbSUPER 17.2 +28.0 27969 1 FOXA2 POLR2A ATF7 NR2F6 HOMEZ SOX5 RXRA NR2F1 FOXA3 HMG20A PIR41509 TXNDC5 BMP6 BLOC1S5 GC06P007902 BLOC1S5-TXNDC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TXNDC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TXNDC5 gene promoter:

Genomic Locations for TXNDC5 Gene

Genomic Locations for TXNDC5 Gene
29,565 bases
Minus strand

Genomic View for TXNDC5 Gene

Genes around TXNDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC5 Gene

Proteins for TXNDC5 Gene

  • Protein details for TXNDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B2RDM2
    • Q5TCQ0
    • Q8ND33
    • Q8TCT2
    • Q9BVH9

    Protein attributes for TXNDC5 Gene

    432 amino acids
    Molecular mass:
    47629 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01199.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TXNDC5 Gene

    Alternative splice isoforms for TXNDC5 Gene


neXtProt entry for TXNDC5 Gene

Post-translational modifications for TXNDC5 Gene

  • Ubiquitination at isoforms=113 and isoforms=2150
  • Glycosylation at posLast=7272
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TXNDC5 Gene

Domains & Families for TXNDC5 Gene

Gene Families for TXNDC5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TXNDC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein disulfide isomerase family.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with TXNDC5: view

Function for TXNDC5 Gene

Molecular function for TXNDC5 Gene

UniProtKB/Swiss-Prot Function:
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).

Phenotypes From GWAS Catalog for TXNDC5 Gene

Gene Ontology (GO) - Molecular Function for TXNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005515 protein binding IPI 21057456
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with TXNDC5: view
genes like me logo Genes that share phenotypes with TXNDC5: view

Animal Models for TXNDC5 Gene

MGI Knock Outs for TXNDC5:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXNDC5 Gene

Localization for TXNDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC5 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC5 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
lysosome 5
cytosol 3
plasma membrane 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with TXNDC5: view

Pathways & Interactions for TXNDC5 Gene

genes like me logo Genes that share pathways with TXNDC5: view

Gene Ontology (GO) - Biological Process for TXNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0043066 negative regulation of apoptotic process TAS 16130169
GO:0043277 apoptotic cell clearance IBA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with TXNDC5: view

No data available for SIGNOR curated interactions for TXNDC5 Gene

Drugs & Compounds for TXNDC5 Gene

No Compound Related Data Available

Transcripts for TXNDC5 Gene

Unigene Clusters for TXNDC5 Gene

Thioredoxin domain containing 5 (endoplasmic reticulum):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC5 Gene

No ASD Table

Relevant External Links for TXNDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNDC5 Gene

This gene is overexpressed in Oral epithelium (11.3) and Tonsil (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC5 Gene

Protein tissue co-expression partners for TXNDC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXNDC5 Gene:


SOURCE GeneReport for Unigene cluster for TXNDC5 Gene:


Evidence on tissue expression from TISSUES for TXNDC5 Gene

  • Lung(4.8)
  • Liver(4.7)
  • Eye(4.6)
  • Lymph node(4.4)
  • Skin(4.3)
  • Intestine(4)
  • Pancreas(3.4)
  • Nervous system(3.3)
  • Kidney(3.1)
  • Heart(2.5)
  • Bone(2.3)
  • Blood(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with TXNDC5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC5 Gene

Orthologs for TXNDC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC5 33 34
  • 99.44 (n)
(Mus musculus)
Mammalia Txndc5 33 16 34
  • 86.81 (n)
(Canis familiaris)
Mammalia TXNDC5 33 34
  • 85.91 (n)
(Rattus norvegicus)
Mammalia Txndc5 33
  • 85.83 (n)
(Bos Taurus)
Mammalia TXNDC5 33 34
  • 85.42 (n)
(Monodelphis domestica)
Mammalia TXNDC5 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TXNDC5 34
  • 69 (a)
(Gallus gallus)
Aves TXNDC5 33 34
  • 74.53 (n)
(Anolis carolinensis)
Reptilia TXNDC5 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc5 33
  • 67.91 (n)
MGC75894 33
(Danio rerio)
Actinopterygii txndc5 33 34
  • 66.25 (n)
Dr.25420 33
fruit fly
(Drosophila melanogaster)
Insecta prtp 33 34
  • 54.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000044 33
  • 53.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPD1 34
  • 19 (a)
EPS1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2468 33
Species where no ortholog for TXNDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC5 Gene

Gene Tree for TXNDC5 (if available)
Gene Tree for TXNDC5 (if available)

Paralogs for TXNDC5 Gene

Paralogs for TXNDC5 Gene

(4) SIMAP similar genes for TXNDC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXNDC5: view

Variants for TXNDC5 Gene

Sequence variations from dbSNP and Humsavar for TXNDC5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000068689 -- 7,903,909(-) C/G intron_variant
rs1000137385 -- 7,893,124(-) A/G intron_variant
rs1000328051 -- 7,892,554(-) T/C intron_variant
rs1000436882 -- 7,887,730(-) C/T intron_variant
rs1000476100 -- 7,908,934(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC5 Gene

Variant ID Type Subtype PubMed ID
esv2731544 CNV deletion 23290073
esv3890787 CNV loss 25118596
nsv1133014 OTHER inversion 24896259
nsv1145091 CNV deletion 24896259
nsv1151332 OTHER inversion 26484159
nsv462625 CNV loss 19166990
nsv600924 CNV gain 21841781
nsv600925 CNV loss 21841781
nsv830582 CNV loss 17160897

Variation tolerance for TXNDC5 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC5 Gene

Disorders for TXNDC5 Gene

Additional Disease Information for TXNDC5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TXNDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC5 Gene

Publications for TXNDC5 Gene

  1. Association of TXNDC5 gene polymorphisms and susceptibility to nonsegmental vitiligo in the Korean population. (PMID: 19906073) Jeong KH … Lee MH (The British journal of dermatology 2010) 3 22 44 58
  2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So HC … Sham PC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  4. Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. (PMID: 19887585) Jessop CE … Bulleid NJ (Journal of cell science 2009) 3 22 58
  5. Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p. (PMID: 19694819) Lin SH … Chen WJ (Genes, brain, and behavior 2009) 3 44 58

Products for TXNDC5 Gene

Sources for TXNDC5 Gene

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