Aliases for TXNDC2 Gene
External Ids for TXNDC2 Gene
Previous GeneCards Identifiers for TXNDC2 Gene
GeneCards Summary for TXNDC2 Gene
TXNDC2 (Thioredoxin Domain Containing 2) is a Protein Coding gene. Diseases associated with TXNDC2 include Chromosome 18P Deletion Syndrome and Pelvic Varices. Gene Ontology (GO) annotations related to this gene include protein disulfide oxidoreductase activity and oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor. An important paralog of this gene is TXN.
UniProtKB/Swiss-Prot Summary for TXNDC2 Gene
Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.