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Aliases for TXNDC2 Gene

Aliases for TXNDC2 Gene

  • Thioredoxin Domain Containing 2 2 3 5
  • Thioredoxin Domain Containing 2 (Spermatozoa) 2 3
  • Spermatid-Specific Thioredoxin-1 3 4
  • Sperm-Specific Thioredoxin 1 2 3
  • Sptrx-1 3 4
  • SPTRX1 3 4
  • SPTRX 3 4
  • Thioredoxin Domain-Containing Protein 2 3
  • Testicular Tissue Protein Li 215 3

External Ids for TXNDC2 Gene

Previous GeneCards Identifiers for TXNDC2 Gene

  • GC18P010019

Summaries for TXNDC2 Gene

GeneCards Summary for TXNDC2 Gene

TXNDC2 (Thioredoxin Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein disulfide oxidoreductase activity and oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor. An important paralog of this gene is TXN.

UniProtKB/Swiss-Prot for TXNDC2 Gene

  • Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

Gene Wiki entry for TXNDC2 Gene

Additional gene information for TXNDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC2 Gene

Genomics for TXNDC2 Gene

GeneHancer (GH) Regulatory Elements for TXNDC2 Gene

Promoters and enhancers for TXNDC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I009885 Promoter/Enhancer 1.3 EPDnew dbSUPER 550.8 +0.2 228 0.1 HDAC1 HDGF ATF1 ASH1L ZBTB40 RELA FOSL1 CC2D1A ZNF766 MTA3 TXNDC2 LOC105371982
GH18I009912 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +30.3 30252 6.3 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 VAPA ENSG00000272799 NAPG TXNDC2 ANKRD12 PPP4R1 RAB31 RNA5SP450
GH18I009823 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -59.3 -59292 6.7 HDGF PKNOX1 ARNT YBX1 ZNF766 ZNF207 FOS REST SMARCB1 KAT8 ANKRD12 VAPA PPP4R1 RAB31 TXNDC2 RALBP1 RN7SL862P ZNF415P1
GH18I009735 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -145.3 -145270 9 HDGF HNRNPUL1 PKNOX1 SMAD1 FOXA2 FEZF1 YY1 POLR2B ZNF766 E2F8 PPP4R1 RAB31 ENSG00000263847 TXNDC2 RNU6-903P VAPA ENSG00000266891 GC18M009550
GH18I009848 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12 -35.9 -35907 2.2 HDGF PKNOX1 ATF1 ARNT ARID2 ATF7 NCOA1 REST ZNF592 GMEB1 RAB31 VAPA TXNDC2 PPP4R1 RNA5SP449 PIGPP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TXNDC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TXNDC2 gene promoter:

Genomic Locations for TXNDC2 Gene

Genomic Locations for TXNDC2 Gene
chr18:9,885,726-9,889,275
(GRCh38/hg38)
Size:
3,550 bases
Orientation:
Plus strand
chr18:9,885,723-9,889,272
(GRCh37/hg19)

Genomic View for TXNDC2 Gene

Genes around TXNDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC2 Gene

Proteins for TXNDC2 Gene

  • Protein details for TXNDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VQ3-TXND2_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 2
    Protein Accession:
    Q86VQ3
    Secondary Accessions:
    • A5YM73
    • Q8N7U4
    • Q96RX3
    • Q9H0L8

    Protein attributes for TXNDC2 Gene

    Size:
    553 amino acids
    Molecular mass:
    60404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TXNDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNDC2 Gene

Post-translational modifications for TXNDC2 Gene

No Post-translational modifications

Other Protein References for TXNDC2 Gene

No data available for DME Specific Peptides for TXNDC2 Gene

Domains & Families for TXNDC2 Gene

Gene Families for TXNDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TXNDC2 Gene

Suggested Antigen Peptide Sequences for TXNDC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TXNDC2: view

No data available for UniProtKB/Swiss-Prot for TXNDC2 Gene

Function for TXNDC2 Gene

Molecular function for TXNDC2 Gene

UniProtKB/Swiss-Prot Function:
Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

Phenotypes From GWAS Catalog for TXNDC2 Gene

Gene Ontology (GO) - Molecular Function for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004791 thioredoxin-disulfide reductase activity ISS --
GO:0015035 protein disulfide oxidoreductase activity IBA --
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA --
GO:0047134 protein-disulfide reductase activity IBA --
genes like me logo Genes that share ontologies with TXNDC2: view
genes like me logo Genes that share phenotypes with TXNDC2: view

Animal Models for TXNDC2 Gene

MGI Knock Outs for TXNDC2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TXNDC2 Gene

Localization for TXNDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC2 Gene

Cytoplasm. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC2 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TXNDC2: view

Pathways & Interactions for TXNDC2 Gene

SuperPathways for TXNDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006662 glycerol ether metabolic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 11399755
GO:0030154 cell differentiation IEA --
GO:0034599 cellular response to oxidative stress IBA --
genes like me logo Genes that share ontologies with TXNDC2: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC2 Gene

Drugs & Compounds for TXNDC2 Gene

(2) Additional Compounds for TXNDC2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with TXNDC2: view

Transcripts for TXNDC2 Gene

Unigene Clusters for TXNDC2 Gene

Thioredoxin domain containing 2 (spermatozoa):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TXNDC2 Gene

GeneLoc Exon Structure for
TXNDC2
ECgene alternative splicing isoforms for
TXNDC2

Expression for TXNDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC2 Gene

mRNA differential expression in normal tissues according to GTEx for TXNDC2 Gene

This gene is overexpressed in Testis (x50.5).

Protein differential expression in normal tissues from HIPED for TXNDC2 Gene

This gene is overexpressed in Ovary (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TXNDC2 Gene



Protein tissue co-expression partners for TXNDC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXNDC2 Gene:

TXNDC2

SOURCE GeneReport for Unigene cluster for TXNDC2 Gene:

Hs.98712

mRNA Expression by UniProt/SwissProt for TXNDC2 Gene:

Q86VQ3-TXND2_HUMAN
Tissue specificity: Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.

Evidence on tissue expression from TISSUES for TXNDC2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TXNDC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC2 Gene

Orthologs for TXNDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC2 33 34
  • 97.63 (n)
dog
(Canis familiaris)
Mammalia TXNDC2 33 34
  • 71.2 (n)
cow
(Bos Taurus)
Mammalia TXNDC2 33 34
  • 69.39 (n)
rat
(Rattus norvegicus)
Mammalia Txndc2 33
  • 69.38 (n)
mouse
(Mus musculus)
Mammalia Txndc2 33 16 34
  • 68.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves TXN 34
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii txn 34
  • 50 (a)
ManyToMany
zgc:56493 34
  • 44 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10782 33
fruit fly
(Drosophila melanogaster)
Insecta Trx-2 34
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trx-1 34
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRX2 34
  • 32 (a)
ManyToMany
TRX3 34
  • 31 (a)
ManyToMany
TRX1 34
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11205 34
  • 38 (a)
ManyToMany
Species where no ortholog for TXNDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TXNDC2 Gene

ENSEMBL:
Gene Tree for TXNDC2 (if available)
TreeFam:
Gene Tree for TXNDC2 (if available)

Paralogs for TXNDC2 Gene

Paralogs for TXNDC2 Gene

genes like me logo Genes that share paralogs with TXNDC2: view

Variants for TXNDC2 Gene

Sequence variations from dbSNP and Humsavar for TXNDC2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000577340 -- 9,889,558(+) T/C downstream_transcript_variant
rs1001615819 -- 9,885,407(+) T/A upstream_transcript_variant
rs1003690898 -- 9,885,800(+) C/T 5_prime_UTR_variant
rs1004037177 -- 9,888,367(+) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1004072626 -- 9,886,493(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC2 Gene

Variant ID Type Subtype PubMed ID
esv2716777 CNV deletion 23290073
esv2716778 CNV deletion 23290073
nsv527829 CNV gain 19592680
nsv833586 CNV loss 17160897

Variation tolerance for TXNDC2 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.93; 91.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC2 Gene

Disorders for TXNDC2 Gene

Additional Disease Information for TXNDC2

No disorders were found for TXNDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC2 Gene

Publications for TXNDC2 Gene

  1. Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa. (PMID: 11399755) Miranda-Vizuete A … Spyrou G (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity. (PMID: 12387870) Jiménez A … Miranda-Vizuete A (FEBS letters 2002) 3 4 22 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TXNDC2 Gene

Sources for TXNDC2 Gene

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