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Aliases for TXNDC15 Gene

Aliases for TXNDC15 Gene

  • Thioredoxin Domain Containing 15 2 3 5
  • C5orf14 3 4
  • Thioredoxin Domain-Containing Protein 15 3
  • Chromosome 5 Open Reading Frame 14 2
  • Disulfide Isomerase 3
  • 2310047H23Rik 3
  • UNQ335 3
  • BUG 3

External Ids for TXNDC15 Gene

Previous HGNC Symbols for TXNDC15 Gene

  • C5orf14

Previous GeneCards Identifiers for TXNDC15 Gene

  • GC05P134238
  • GC05P129395
  • GC05P134211

Summaries for TXNDC15 Gene

Entrez Gene Summary for TXNDC15 Gene

  • This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. [provided by RefSeq, Apr 2017]

GeneCards Summary for TXNDC15 Gene

TXNDC15 (Thioredoxin Domain Containing 15) is a Protein Coding gene. Diseases associated with TXNDC15 include Meckel Syndrome, Type 1.

Additional gene information for TXNDC15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC15 Gene

Genomics for TXNDC15 Gene

GeneHancer (GH) Regulatory Elements for TXNDC15 Gene

Promoters and enhancers for TXNDC15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I134873 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.2 +1.3 1251 3.2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF143 ZNF207 FOS TXNDC15 JADE2 C5orf24 DDX46 PIR56260
GH05I134844 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 25.3 -27.1 -27147 3.5 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 ZNF207 C5orf24 DDX46 C5orf66 TXNDC15 CAMLG JADE2 SEC24A ENSG00000270021 GC05M134654
GH05I134646 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.6 -224.8 -224754 4.4 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SAR1B GC05M134647 SEC24A TXNDC15 DDX46 C5orf66
GH05I134630 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13 -241.6 -241570 2.5 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D SAR1B DDX46 JADE2 C5orf24 C5orf66 TXNDC15 SEC24A SKP1 C5orf66-AS1 CAMLG
GH05I134464 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -407.5 -407512 2.8 PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DDX46 C5orf24 TXNDC15 C5orf66 PPP2CA SEC24A UBE2B LOC102546229 ENSG00000250994 RNU6-456P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TXNDC15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TXNDC15 gene promoter:

Genomic Locations for TXNDC15 Gene

Genomic Locations for TXNDC15 Gene
27,864 bases
Plus strand

Genomic View for TXNDC15 Gene

Genes around TXNDC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC15 Gene

Proteins for TXNDC15 Gene

  • Protein details for TXNDC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 15
    Protein Accession:
    Secondary Accessions:
    • D3DQA9
    • Q96MT2
    • Q9H639

    Protein attributes for TXNDC15 Gene

    360 amino acids
    Molecular mass:
    39885 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TXNDC15 Gene


neXtProt entry for TXNDC15 Gene

Post-translational modifications for TXNDC15 Gene

  • Ubiquitination at posLast=272272
  • Glycosylation at posLast=187187, isoforms=2194, posLast=206206, and isoforms=2293

Other Protein References for TXNDC15 Gene

No data available for DME Specific Peptides for TXNDC15 Gene

Domains & Families for TXNDC15 Gene

Gene Families for TXNDC15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TXNDC15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TXNDC15: view

No data available for UniProtKB/Swiss-Prot for TXNDC15 Gene

Function for TXNDC15 Gene

Phenotypes From GWAS Catalog for TXNDC15 Gene

genes like me logo Genes that share phenotypes with TXNDC15: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC15 Gene

Localization for TXNDC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC15 gene
Compartment Confidence
mitochondrion 2
golgi apparatus 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TXNDC15: view

Pathways & Interactions for TXNDC15 Gene

SuperPathways for TXNDC15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC15: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC15 Gene

Drugs & Compounds for TXNDC15 Gene

No Compound Related Data Available

Transcripts for TXNDC15 Gene

Unigene Clusters for TXNDC15 Gene

Thioredoxin domain containing 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - -
SP7: -

Relevant External Links for TXNDC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC15 Gene

Protein differential expression in normal tissues from HIPED for TXNDC15 Gene

This gene is overexpressed in Breast (34.8), Heart (9.1), and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC15 Gene

Protein tissue co-expression partners for TXNDC15 Gene

NURSA nuclear receptor signaling pathways regulating expression of TXNDC15 Gene:


SOURCE GeneReport for Unigene cluster for TXNDC15 Gene:


Evidence on tissue expression from TISSUES for TXNDC15 Gene

  • Intestine(4.3)
  • Kidney(4.3)
  • Liver(4.3)
  • Pancreas(4.2)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with TXNDC15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC15 Gene

Orthologs for TXNDC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNDC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC15 33 34
  • 99.33 (n)
(Bos Taurus)
Mammalia TXNDC15 33 34
  • 87.32 (n)
(Canis familiaris)
Mammalia TXNDC15 33 34
  • 85.06 (n)
(Mus musculus)
Mammalia Txndc15 33 16 34
  • 79.94 (n)
(Rattus norvegicus)
Mammalia Txndc15 33
  • 78.62 (n)
(Ornithorhynchus anatinus)
Mammalia TXNDC15 34
  • 74 (a)
(Monodelphis domestica)
Mammalia TXNDC15 34
  • 65 (a)
(Gallus gallus)
Aves TXNDC15 33 34
  • 63.58 (n)
(Anolis carolinensis)
Reptilia TXNDC15 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc15 33
  • 64.05 (n)
Str.7095 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12492 33
(Danio rerio)
Actinopterygii zgc:165608 33
  • 60.98 (n)
TXNDC15 34
  • 52 (a)
Dr.16773 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11182 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for TXNDC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC15 Gene

Gene Tree for TXNDC15 (if available)
Gene Tree for TXNDC15 (if available)

Paralogs for TXNDC15 Gene

(1) SIMAP similar genes for TXNDC15 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TXNDC15: view

No data available for Paralogs for TXNDC15 Gene

Variants for TXNDC15 Gene

Sequence variations from dbSNP and Humsavar for TXNDC15 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs886039791 likely-pathogenic, Meckel-Gruber syndrome 134,893,572(+) CAGTTTGGCCCCTCAC/C coding_sequence_variant, inframe_deletion
rs886039792 likely-pathogenic, Meckel-Gruber syndrome 134,874,531(+) G/A splice_donor_variant
VAR_036172 A breast cancer sample p.Ser248Pro
rs1000300535 -- 134,885,245(+) G/C intron_variant
rs1000330596 -- 134,875,564(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC15 Gene

Variant ID Type Subtype PubMed ID
esv2674924 CNV deletion 23128226
esv3606852 CNV loss 21293372
nsv830493 CNV loss 17160897
nsv830494 CNV gain+loss 17160897

Variation tolerance for TXNDC15 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNDC15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC15 Gene

Disorders for TXNDC15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXNDC15 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
meckel syndrome, type 1
  • mks1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TXNDC15

genes like me logo Genes that share disorders with TXNDC15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNDC15 Gene

Publications for TXNDC15 Gene

  1. Characterizing the morbid genome of ciliopathies. (PMID: 27894351) Shaheen R … Alkuraya FS (Genome biology 2016) 2 3 58
  2. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TXNDC15 Gene

Sources for TXNDC15 Gene

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