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Aliases for TXNDC11 Gene

Aliases for TXNDC11 Gene

  • Thioredoxin Domain Containing 11 2 3 5
  • EF-Hand Binding Protein 1 2 3
  • EFP1 3 4
  • Thioredoxin Domain-Containing Protein 11 3
  • EF-Hand-Binding Protein 1 4

External Ids for TXNDC11 Gene

Previous GeneCards Identifiers for TXNDC11 Gene

  • GC16M011681
  • GC16M011772

Summaries for TXNDC11 Gene

GeneCards Summary for TXNDC11 Gene

TXNDC11 (Thioredoxin Domain Containing 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein disulfide isomerase activity.

UniProtKB/Swiss-Prot for TXNDC11 Gene

  • May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

Additional gene information for TXNDC11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC11 Gene

Genomics for TXNDC11 Gene

GeneHancer (GH) Regulatory Elements for TXNDC11 Gene

Promoters and enhancers for TXNDC11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I011740 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.1 +0.1 133 4.9 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC TXNDC11 ENSG00000262420 GC16P011744 RSL1D1 ENSG00000263013 LOC105371083
GH16I011667 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.2 +72.5 72485 6.7 IRF4 ZNF48 GLIS2 ZNF143 ATF7 FOS RUNX3 SP5 NFYC MXD4 SNN ZC3H7A TXNDC11 LITAF LOC105371084 ENSG00000261560 HNRNPCP4 RSL1D1 COX6CP1 SNX29
GH16I011639 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20.4 +102.2 102220 3.3 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 LOC105371084 HNRNPCP4 ENSG00000261560 LITAF COX6CP1 ZC3H7A ENSG00000261216 TXNDC11 NPIPB2 SOCS1
GH16I011611 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +128.7 128656 4.8 PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LITAF TXNDC11 LOC105371084 ZC3H7A ENSG00000261560 HNRNPCP4 SOCS1 COX6CP1 ENSG00000261216 SNN
GH16I011674 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +63.5 63545 9.9 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 TXNDC11 ZC3H7A SNN LITAF SNX29 SOCS1 ENSG00000262420
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TXNDC11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TXNDC11 gene promoter:

Genomic Locations for TXNDC11 Gene

Genomic Locations for TXNDC11 Gene
63,799 bases
Minus strand

Genomic View for TXNDC11 Gene

Genes around TXNDC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC11 Gene

Proteins for TXNDC11 Gene

  • Protein details for TXNDC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 11
    Protein Accession:
    Secondary Accessions:
    • O95887
    • Q6PJA6
    • Q8N2Q4
    • Q96K45
    • Q96K53

    Protein attributes for TXNDC11 Gene

    985 amino acids
    Molecular mass:
    110529 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA.
    • Sequence=AAD20043.1; Type=Frameshift; Positions=618; Evidence={ECO:0000305}; Sequence=AAH13727.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55129.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11044.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TXNDC11 Gene


neXtProt entry for TXNDC11 Gene

Post-translational modifications for TXNDC11 Gene

  • Glycosylation at isoforms=2326 and isoforms=2337
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TXNDC11 Gene

Domains & Families for TXNDC11 Gene

Gene Families for TXNDC11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TXNDC11 Gene

Suggested Antigen Peptide Sequences for TXNDC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein disulfide isomerase family.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with TXNDC11: view

Function for TXNDC11 Gene

Molecular function for TXNDC11 Gene

UniProtKB/Swiss-Prot Function:
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

Phenotypes From GWAS Catalog for TXNDC11 Gene

Gene Ontology (GO) - Molecular Function for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with TXNDC11: view
genes like me logo Genes that share phenotypes with TXNDC11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNDC11

miRNA for TXNDC11 Gene

miRTarBase miRNAs that target TXNDC11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC11 Gene

Localization for TXNDC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC11 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC11 gene
Compartment Confidence
plasma membrane 4
cytosol 4
endoplasmic reticulum 3
extracellular 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TXNDC11: view

Pathways & Interactions for TXNDC11 Gene

SuperPathways for TXNDC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC11: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC11 Gene

Drugs & Compounds for TXNDC11 Gene

No Compound Related Data Available

Transcripts for TXNDC11 Gene

Unigene Clusters for TXNDC11 Gene

Thioredoxin domain containing 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP4: -
SP5: - - - -
SP6: - - -
SP9: - - - -

Relevant External Links for TXNDC11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC11 Gene

Protein differential expression in normal tissues from HIPED for TXNDC11 Gene

This gene is overexpressed in Tlymphocyte (26.6), Stomach (14.2), Liver (9.0), and Spinal cord (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TXNDC11 Gene:


SOURCE GeneReport for Unigene cluster for TXNDC11 Gene:


mRNA Expression by UniProt/SwissProt for TXNDC11 Gene:

Tissue specificity: Widely expressed at low level. Expressed at higher level in thyroid and prostate.

Evidence on tissue expression from TISSUES for TXNDC11 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with TXNDC11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC11 Gene

Orthologs for TXNDC11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC11 34
  • 96 (a)
(Canis familiaris)
Mammalia TXNDC11 33 34
  • 88.61 (n)
(Bos Taurus)
Mammalia TXNDC11 33 34
  • 87.5 (n)
(Mus musculus)
Mammalia Txndc11 33 16 34
  • 83.3 (n)
(Rattus norvegicus)
Mammalia Txndc11 33
  • 82.99 (n)
(Monodelphis domestica)
Mammalia TXNDC11 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
-- 34
  • 58 (a)
(Gallus gallus)
Aves TXNDC11 33 34
  • 68.88 (n)
(Anolis carolinensis)
Reptilia TXNDC11 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc11 33
  • 62.31 (n)
(Danio rerio)
Actinopterygii LOC100330433 33
  • 56.28 (n)
txndc11 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13671 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
CSA.8061 34
  • 22 (a)
Species where no ortholog for TXNDC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC11 Gene

Gene Tree for TXNDC11 (if available)
Gene Tree for TXNDC11 (if available)

Paralogs for TXNDC11 Gene Pseudogenes for TXNDC11 Gene

genes like me logo Genes that share paralogs with TXNDC11: view

No data available for Paralogs for TXNDC11 Gene

Variants for TXNDC11 Gene

Sequence variations from dbSNP and Humsavar for TXNDC11 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000022319 -- 11,702,470(-) C/A intron_variant
rs1000038569 -- 11,742,190(-) A/C intron_variant
rs1000091654 -- 11,707,451(-) C/T intron_variant
rs1000130010 -- 11,707,296(-) G/A intron_variant
rs1000164885 -- 11,706,432(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC11 Gene

Variant ID Type Subtype PubMed ID
esv2662947 CNV deletion 23128226
esv3637933 CNV loss 21293372
esv3637934 CNV gain 21293372
esv3637935 CNV loss 21293372
esv3637936 CNV gain 21293372
nsv1734 CNV insertion 18451855
nsv457409 CNV gain 19166990
nsv478577 CNV novel sequence insertion 20440878
nsv524676 CNV loss 19592680
nsv525726 CNV gain 19592680
nsv571456 CNV gain 21841781

Variation tolerance for TXNDC11 Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.57; 97.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNDC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC11 Gene

Disorders for TXNDC11 Gene

Additional Disease Information for TXNDC11

No disorders were found for TXNDC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC11 Gene

Publications for TXNDC11 Gene

  1. Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. (PMID: 15561711) Wang D … Miot F (The Journal of biological chemistry 2005) 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58

Products for TXNDC11 Gene

Sources for TXNDC11 Gene

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