Aliases for TXN2 Gene
External Ids for TXN2 Gene
Previous GeneCards Identifiers for TXN2 Gene
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TXN2 Gene
TXN2 (Thioredoxin 2) is a Protein Coding gene. Diseases associated with TXN2 include Combined Oxidative Phosphorylation Deficiency 29 and Triosephosphate Isomerase Deficiency. Among its related pathways are Glucose / Energy Metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor. An important paralog of this gene is TXNDC2.
UniProtKB/Swiss-Prot Summary for TXN2 Gene
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.