Aliases for TXN2 Gene
External Ids for TXN2 Gene
Previous GeneCards Identifiers for TXN2 Gene
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TXN2 Gene
TXN2 (Thioredoxin 2) is a Protein Coding gene. Diseases associated with TXN2 include Combined Oxidative Phosphorylation Deficiency 29 and Ocular Hypertension. Among its related pathways are Detoxification of Reactive Oxygen Species and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein complex binding and oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor.
UniProtKB/Swiss-Prot for TXN2 Gene
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.