This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit acti... See more...

Aliases for TXLNG Gene

Aliases for TXLNG Gene

  • Taxilin Gamma 2 3 5
  • FIAT 2 3 4
  • LSR5 2 3 4
  • Factor Inhibiting Activating Transcription Factor 4 (ATF4)-Mediated Transcription 2 3
  • Environmental Lipopolysaccharide-Responding Gene Protein 3 4
  • Lipopolysaccharide Specific Response-5 Protein 2 3
  • Lipopolysaccharide-Specific Response Protein 5 3 4
  • Factor Inhibiting ATF4-Mediated Transcription 3 4
  • Gamma-Taxilin 3 4
  • CXorf15 3 4
  • TXLNGX 2 3
  • ELRG 3 4
  • Chromosome X Open Reading Frame 15 2
  • Environmental LPS-Responding 3
  • MGC126621 2
  • MGC126625 2
  • FLJ11209 2
  • TXLNG 5

External Ids for TXLNG Gene

Previous HGNC Symbols for TXLNG Gene

  • CXorf15

Previous GeneCards Identifiers for TXLNG Gene

  • GC0XP016804
  • GC0XP014564

Summaries for TXLNG Gene

Entrez Gene Summary for TXLNG Gene

  • This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for TXLNG Gene

TXLNG (Taxilin Gamma) is a Protein Coding gene. Diseases associated with TXLNG include Palmoplantar Keratoderma And Congenital Alopecia 2. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and syntaxin binding. An important paralog of this gene is TXLNA.

UniProtKB/Swiss-Prot Summary for TXLNG Gene

  • May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.

Additional gene information for TXLNG Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TXLNG Gene

Genomics for TXLNG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TXLNG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ016785 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 605 +0.3 269 3 SP1 CREB1 PRDM10 ZNF629 SIX5 IKZF1 ZNF692 POLR2A PRDM1 ZNF143 TXLNG RBBP7 RPL12P49
GH0XJ016603 Enhancer 1 Ensembl ENCODE 32.5 -181.7 -181732 4.6 IKZF1 FOXA1 POLR2A DPF2 GABPA ZNF341 TCF12 SOX13 ZNF140 TCF7 TXLNG CTPS2 S100G piR-61580-659 MIR548AM MAGEB17
GH0XJ016822 Enhancer 1 Ensembl ENCODE 26.5 +39.4 39373 7.2 GATAD2A CTCF ZNF629 ZNF692 PRDM1 REST RAD21 SP1 YY1 CEBPA RBBP7 TXLNG ENSG00000201467 CTPS2 HSALNG0136834 piR-43105-685
GH0XJ016184 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.9 -599.7 -599732 4.2 JUND PKNOX1 DPF2 YY1 ZNF37A HMBOX1 RUNX3 NFE2 ZNF316 USF1 TXLNG GRPR CTPS2 ZRSR2 ENSG00000238178 RPL6P30 MAGEB17 S100G
GH0XJ015883 Enhancer 1 Ensembl ENCODE 13.6 -903.4 -903431 2 RFX1 DDX20 ZNF740 TRIM22 YY1 ZSCAN29 GTF2E2 ZNF766 DPF2 RUNX3 ZRSR2 CTPS2 TXLNG piR-61514-215 AP1S2 RF00020-027 RNU5F-7P GRPR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TXLNG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TXLNG

Genomic Locations for TXLNG Gene

Genomic Locations for TXLNG Gene
chrX:16,786,432-16,844,519
(GRCh38/hg38)
Size:
58,088 bases
Orientation:
Plus strand
chrX:16,804,550-16,862,642
(GRCh37/hg19)
Size:
58,093 bases
Orientation:
Plus strand

Genomic View for TXLNG Gene

Genes around TXLNG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXLNG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXLNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNG Gene

Proteins for TXLNG Gene

  • Protein details for TXLNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUQ3-TXLNG_HUMAN
    Recommended name:
    Gamma-taxilin
    Protein Accession:
    Q9NUQ3
    Secondary Accessions:
    • Q2KQ75
    • Q5JNZ7
    • Q9P0X1

    Protein attributes for TXLNG Gene

    Size:
    528 amino acids
    Molecular mass:
    60586 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.
    Miscellaneous:
    • Depletion of TXLNG by siRNA decreases the percentage of Hep-G2 cells arrested in G1 phase.

    Alternative splice isoforms for TXLNG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXLNG Gene

Post-translational modifications for TXLNG Gene

  • Ubiquitination at Lys275
  • Modification sites at PhosphoSitePlus

Other Protein References for TXLNG Gene

No data available for DME Specific Peptides for TXLNG Gene

Domains & Families for TXLNG Gene

Gene Families for TXLNG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TXLNG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TXLNG Gene

GenScript: Design optimal peptide antigens:
  • Lipopolysaccharide-specific response protein 5 (TXLNG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NUQ3

UniProtKB/Swiss-Prot:

TXLNG_HUMAN :
  • Belongs to the taxilin family.
Family:
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNG: view

Function for TXLNG Gene

Molecular function for TXLNG Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS) in Hep-G2 cells.

Phenotypes From GWAS Catalog for TXLNG Gene

Gene Ontology (GO) - Molecular Function for TXLNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 15911876
GO:0019905 syntaxin binding IEA --
GO:0033613 activating transcription factor binding IPI 15911876
genes like me logo Genes that share ontologies with TXLNG: view
genes like me logo Genes that share phenotypes with TXLNG: view

Animal Models for TXLNG Gene

MGI Knock Outs for TXLNG:

Animal Model Products

CRISPR Products

miRNA for TXLNG Gene

miRTarBase miRNAs that target TXLNG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXLNG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXLNG Gene

Localization for TXLNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXLNG Gene

Nucleus membrane. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXLNG gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TXLNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol ISS --
GO:0016020 membrane IEA --
GO:0031965 nuclear membrane IEA,IDA 15911876
genes like me logo Genes that share ontologies with TXLNG: view

Pathways & Interactions for TXLNG Gene

genes like me logo Genes that share pathways with TXLNG: view

Pathways by source for TXLNG Gene

Gene Ontology (GO) - Biological Process for TXLNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0010564 regulation of cell cycle process IMP 18068885
GO:0030500 regulation of bone mineralization ISS --
GO:0051726 regulation of cell cycle ISS --
genes like me logo Genes that share ontologies with TXLNG: view

No data available for SIGNOR curated interactions for TXLNG Gene

Drugs & Compounds for TXLNG Gene

No Compound Related Data Available

Transcripts for TXLNG Gene

mRNA/cDNA for TXLNG Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXLNG

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNG Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1:
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for TXLNG Gene

GeneLoc Exon Structure for
TXLNG

Expression for TXLNG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TXLNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXLNG Gene

This gene is overexpressed in Fetal ovary (14.8), Adrenal (13.8), Breast (10.7), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TXLNG Gene



Protein tissue co-expression partners for TXLNG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TXLNG

SOURCE GeneReport for Unigene cluster for TXLNG Gene:

Hs.555961

mRNA Expression by UniProt/SwissProt for TXLNG Gene:

Q9NUQ3-TXLNG_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.

Evidence on tissue expression from TISSUES for TXLNG Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Skin(2.3)
  • Heart(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TXLNG: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXLNG Gene

Orthologs for TXLNG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXLNG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TXLNG 30 31
  • 98.74 (n)
OneToMany
CYHYorf15A 31
  • 71 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm8258 31
  • 94 (a)
OneToMany
Txlng 30 17 31
  • 88.93 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia TXLNG 30 31
  • 89.4 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 87 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Txlng 30
  • 86.78 (n)
Cow
(Bos Taurus)
Mammalia TXLNG 30 31
  • 86.51 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TXLNG 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TXLNG 30 31
  • 76.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TXLNG 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia txlng 30
  • 67.85 (n)
Str.1600 30
Zebrafish
(Danio rerio)
Actinopterygii txlng 30 31
  • 65.07 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG5886 31
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T22C1.6 31
  • 26 (a)
OneToMany
Corn
(Zea mays)
Liliopsida Zm.12913 30
Species where no ortholog for TXLNG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TXLNG Gene

ENSEMBL:
Gene Tree for TXLNG (if available)
TreeFam:
Gene Tree for TXLNG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TXLNG: view image

Paralogs for TXLNG Gene

Paralogs for TXLNG Gene

(5) SIMAP similar genes for TXLNG Gene using alignment to 1 proteins:

  • TXLNG_HUMAN

Pseudogenes.org Pseudogenes for TXLNG Gene

genes like me logo Genes that share paralogs with TXLNG: view

Variants for TXLNG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TXLNG Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
714920 Benign: not provided 16,841,706(+) A/C MISSENSE_VARIANT
rs5969783 - p.Ile246Val

Additional dbSNP identifiers (rs#s) for TXLNG Gene

Structural Variations from Database of Genomic Variants (DGV) for TXLNG Gene

Variant ID Type Subtype PubMed ID
esv2668322 CNV deletion 23128226

Variation tolerance for TXLNG Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXLNG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXLNG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNG Gene

Disorders for TXLNG Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXLNG Gene - From: DISEASES

Disorder Aliases PubMed IDs
palmoplantar keratoderma and congenital alopecia 2
  • ppkca2
- elite association - COSMIC cancer census association via MalaCards
Search TXLNG in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TXLNG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXLNG Gene

Publications for TXLNG Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S … Shirataki H (Biochemical and biophysical research communications 2004) 2 3 4 23
  2. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. (PMID: 15911876) Yu VW … St-Arnaud R (The Journal of cell biology 2005) 2 3 4
  3. Over-expression and siRNA of a novel environmental lipopolysaccharide-responding gene on the cell cycle of the human hepatoma-derived cell line HepG2. (PMID: 18068885) Du K … Chen J (Toxicology 2008) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  5. Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin modulates bone mass accrual. (PMID: 16831913) Yu VW … St-Arnaud R (Annals of the New York Academy of Sciences 2006) 2 3

Products for TXLNG Gene

Sources for TXLNG Gene