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This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
TXLNG (Taxilin Gamma) is a Protein Coding gene. Diseases associated with TXLNG include Palmoplantar Keratoderma And Congenital Alopecia 2. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and syntaxin binding. An important paralog of this gene is TXLNA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008134 | transcription factor binding | IPI | 15911876 |
GO:0019905 | syntaxin binding | IEA | -- |
GO:0033613 | activating transcription factor binding | IPI | 15911876 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | ISS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031965 | nuclear membrane | IEA,IDA | 15911876 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007049 | cell cycle | IEA | -- |
GO:0010564 | regulation of cell cycle process | IMP | 18068885 |
GO:0030500 | regulation of bone mineralization | ISS | -- |
GO:0051726 | regulation of cell cycle | ISS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TXLNG 30 31 |
|
OneToMany | |
CYHYorf15A 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Gm8258 31 |
|
OneToMany | |
Txlng 30 17 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | TXLNG 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Txlng 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TXLNG 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TXLNG 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TXLNG 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TXLNG 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | txlng 30 |
|
||
Str.1600 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | txlng 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5886 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | T22C1.6 31 |
|
OneToMany | |
Corn (Zea mays) |
Liliopsida | Zm.12913 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2668322 | CNV | deletion | 23128226 |
Disorder | Aliases | PubMed IDs |
---|---|---|
palmoplantar keratoderma and congenital alopecia 2 |
|
|