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Aliases for TXLNA Gene

Aliases for TXLNA Gene

  • Taxilin Alpha 2 3 5
  • TXLN 3 4
  • Interleukin 14 3
  • Alpha-Taxilin 3
  • IL14 3

External Ids for TXLNA Gene

Previous GeneCards Identifiers for TXLNA Gene

  • GC01P032315
  • GC01P032417
  • GC01P032645
  • GC01P030761

Summaries for TXLNA Gene

GeneCards Summary for TXLNA Gene

TXLNA (Taxilin Alpha) is a Protein Coding gene. Diseases associated with TXLNA include B-Cell Growth Factor and Inclusion Conjunctivitis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity and high molecular weight B cell growth factor receptor binding. An important paralog of this gene is TXLNG.

UniProtKB/Swiss-Prot for TXLNA Gene

  • May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Wiki entry for TXLNA Gene

Additional gene information for TXLNA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNA Gene

Genomics for TXLNA Gene

GeneHancer (GH) Regulatory Elements for TXLNA Gene

Promoters and enhancers for TXLNA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I032178 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 564.1 +0.7 659 4.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B TXLNA ENSG00000224066 IQCC DCDC2B SNRNP40 TSSK3 KPNA6 RBBP4 TMEM234 EIF3I
GH01I031924 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 121.7 -243.9 -243853 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 PTP4A2 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B
GH01I032813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 63.1 +637.6 637556 7.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 S100PBP YARS TXLNA TSSK3 RBBP4 ZBTB8A KHDRBS1 TMEM39B EIF3I FAM229A
GH01I032262 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 98 +85.7 85702 4.8 ZNF493 ZNF529 ZFP64 RARA ZNF213 SCRT2 ZNF654 ZNF680 ZBTB11 CEBPB TXLNA RBBP4 SNRNP40 KHDRBS1 TSSK3 TMEM39B ZBTB8A ZNF362 DCDC2B S100PBP
GH01I031951 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 70.1 -223.6 -223616 9.1 DMAP1 YBX1 IRF4 YY1 E2F8 ZC3H11A MEF2D GLIS1 RCOR2 NBN SNRNP40 KHDRBS1 TXLNA RBBP4 TSSK3 TMEM39B ENSG00000229447 ZBTB8A IQCC ENSG00000228634
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TXLNA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TXLNA gene promoter:

Genomic Locations for TXLNA Gene

Genomic Locations for TXLNA Gene
chr1:32,179,686-32,198,285
(GRCh38/hg38)
Size:
18,600 bases
Orientation:
Plus strand
chr1:32,645,287-32,663,886
(GRCh37/hg19)

Genomic View for TXLNA Gene

Genes around TXLNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXLNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXLNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNA Gene

Proteins for TXLNA Gene

  • Protein details for TXLNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40222-TXLNA_HUMAN
    Recommended name:
    Alpha-taxilin
    Protein Accession:
    P40222
    Secondary Accessions:
    • D3DPP6
    • Q5TFJ6
    • Q66K62
    • Q86T54
    • Q86T85
    • Q86T86
    • Q86Y86
    • Q86YW3
    • Q8N2Y3

    Protein attributes for TXLNA Gene

    Size:
    546 amino acids
    Molecular mass:
    61891 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.
    SequenceCaution:
    • Sequence=AAH46565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXLNA Gene

Post-translational modifications for TXLNA Gene

  • Ubiquitination at isoforms=403
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TXLNA Gene

Domains & Families for TXLNA Gene

Gene Families for TXLNA Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TXLNA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TXLNA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40222

UniProtKB/Swiss-Prot:

TXLNA_HUMAN :
  • Belongs to the taxilin family.
Family:
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNA: view

Function for TXLNA Gene

Molecular function for TXLNA Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Ontology (GO) - Molecular Function for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 8327514
GO:0005515 protein binding IPI 21903422
GO:0019905 syntaxin binding IEA --
GO:0030372 high molecular weight B cell growth factor receptor binding NAS 8327514
genes like me logo Genes that share ontologies with TXLNA: view
genes like me logo Genes that share phenotypes with TXLNA: view

Animal Model Products

miRNA for TXLNA Gene

miRTarBase miRNAs that target TXLNA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXLNA Gene

Localization for TXLNA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXLNA gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 8327514
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with TXLNA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TXLNA Gene

Pathways & Interactions for TXLNA Gene

genes like me logo Genes that share pathways with TXLNA: view

Pathways by source for TXLNA Gene

Gene Ontology (GO) - Biological Process for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0008283 cell proliferation NAS 8327514
GO:0010469 regulation of receptor activity IEA --
GO:0042113 B cell activation IEA --
genes like me logo Genes that share ontologies with TXLNA: view

No data available for SIGNOR curated interactions for TXLNA Gene

Drugs & Compounds for TXLNA Gene

(1) Drugs for TXLNA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with TXLNA: view

Transcripts for TXLNA Gene

Unigene Clusters for TXLNA Gene

Taxilin alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for TXLNA Gene

GeneLoc Exon Structure for
TXLNA
ECgene alternative splicing isoforms for
TXLNA

Expression for TXLNA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXLNA Gene

Protein differential expression in normal tissues from HIPED for TXLNA Gene

This gene is overexpressed in Breast (25.6), Urine (8.0), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXLNA Gene



Protein tissue co-expression partners for TXLNA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXLNA Gene:

TXLNA

SOURCE GeneReport for Unigene cluster for TXLNA Gene:

Hs.17987

mRNA Expression by UniProt/SwissProt for TXLNA Gene:

P40222-TXLNA_HUMAN
Tissue specificity: Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.

Evidence on tissue expression from TISSUES for TXLNA Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TXLNA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXLNA Gene

Orthologs for TXLNA Gene

This gene was present in the common ancestor of animals.

Orthologs for TXLNA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXLNA 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TXLNA 33 34
  • 90.15 (n)
cow
(Bos Taurus)
Mammalia TXLNA 33 34
  • 89.54 (n)
mouse
(Mus musculus)
Mammalia Txlna 33 16 34
  • 87.39 (n)
rat
(Rattus norvegicus)
Mammalia Txlna 33
  • 87.34 (n)
oppossum
(Monodelphis domestica)
Mammalia TXLNA 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXLNA 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXLNA 33 34
  • 73.69 (n)
lizard
(Anolis carolinensis)
Reptilia TXLNA 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1214 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7529 33
zebrafish
(Danio rerio)
Actinopterygii txlna 33 34
  • 70.88 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009667 33
  • 55.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 33 34
  • 53.64 (n)
worm
(Caenorhabditis elegans)
Secernentea T22C1.6 33 34
  • 43.64 (n)
Species where no ortholog for TXLNA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNA Gene

ENSEMBL:
Gene Tree for TXLNA (if available)
TreeFam:
Gene Tree for TXLNA (if available)

Paralogs for TXLNA Gene

Paralogs for TXLNA Gene

(5) SIMAP similar genes for TXLNA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXLNA: view

Variants for TXLNA Gene

Sequence variations from dbSNP and Humsavar for TXLNA Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000056294 -- 32,186,268(+) G/A intron_variant
rs1000089966 -- 32,185,830(+) C/T intron_variant
rs1000119851 -- 32,190,702(+) A/G intron_variant
rs1000374182 -- 32,197,781(+) T/C 3_prime_UTR_variant
rs1000464886 -- 32,183,782(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXLNA Gene

Variant ID Type Subtype PubMed ID
nsv7745 CNV insertion 18451855

Variation tolerance for TXLNA Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXLNA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXLNA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNA Gene

Disorders for TXLNA Gene

MalaCards: The human disease database

(3) MalaCards diseases for TXLNA Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TXLNA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TXLNA

genes like me logo Genes that share disorders with TXLNA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXLNA Gene

Publications for TXLNA Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S … Shirataki H (Biochemical and biophysical research communications 2004) 2 3 22 58
  2. Interaction of taxilin with syntaxin which does not form the SNARE complex. (PMID: 14623251) Nogami S … Shirataki H (Biochemical and biophysical research communications 2003) 2 3 4 58
  3. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells. (PMID: 12558796) Nogami S … Shirataki H (Genes to cells : devoted to molecular & cellular mechanisms 2003) 3 4 22 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TXLNA Gene

Sources for TXLNA Gene

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