Aliases for TXK Gene

Aliases for TXK Gene

  • TXK Tyrosine Kinase 2 3 5
  • RLK 2 3 4
  • PTK4 Protein Tyrosine Kinase 4 2 3
  • Tyrosine-Protein Kinase TXK 3 4
  • Protein-Tyrosine Kinase 4 3 4
  • Resting Lymphocyte Kinase 3 4
  • EC 2.7.10.2 4 51
  • PSCTK5 2 3
  • BTKL 2 3
  • PTK4 3 4
  • TKL 2 3
  • EC 2.7.10 51
  • TXK 5

External Ids for TXK Gene

Previous HGNC Symbols for TXK Gene

  • PTK4

Previous GeneCards Identifiers for TXK Gene

  • GC04M048145
  • GC04M048378
  • GC04M047918
  • GC04M047984
  • GC04M047909
  • GC04M047763
  • GC04M047388

Summaries for TXK Gene

GeneCards Summary for TXK Gene

TXK (TXK Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TXK include Agammaglobulinemia and Behcet Syndrome. Among its related pathways are Sweet Taste Signaling and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot Summary for TXK Gene

  • Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Gene Wiki entry for TXK Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TXK Gene

Genomics for TXK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TXK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J048126 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 611.9 +4.6 4645 8.6 CTCF TEAD4 LEF1 IKZF1 ZNF692 POLR2A BACH1 JUND FOXA1 ZNF24 TXK TEC RNU6-838P ENSG00000248254 CNGA1 ZAR1 ENSG00000283499
GH04J048079 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.2 +54.6 54622 3.4 FOXA1 PKNOX1 ZNF24 ZNF740 SP1 CEBPB JUN MEF2D ZNF592 JUND TXK NIPAL1 RNU6-838P CNGA1 NFXL1 ENSG00000259959 SLAIN2 CWH43 piR-55985-142 RF00026-781
GH04J048135 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 609 -2.8 -2840 5.6 RFX1 POLR2A CTCF RELA RELB RUNX3 BMI1 MTA2 NFE2L2 SPI1 TXK RNU6-838P TEC CNGA1 NIPAL1 ENSG00000248254 lnc-TXK-1
GH04J048336 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.1 -205.5 -205479 8 SP1 GATAD2A PRDM10 REST SOX13 NFKBIZ POLR2A ZNF692 BACH1 TARDBP SLAIN2 lnc-TEC-2 TEC NFXL1 ZAR1 TXK SLC10A4 lnc-TEC-1
GH04J048172 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -38.8 -38793 4.2 TEAD4 PRDM10 IKZF1 JUND PRDM1 RELA ZNF24 TCF12 IKZF2 ZNF740 TXK TEC CNGA1 NIPAL1 ENSG00000248254 NFXL1 RF00017-4306 piR-43583-404
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TXK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TXK

Top Transcription factor binding sites by QIAGEN in the TXK gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myb
  • IRF-2
  • POU2F1
  • POU2F1a
  • RSRFC4
  • STAT1
  • STAT1alpha

Genomic Locations for TXK Gene

Genomic Locations for TXK Gene
chr4:48,063,504-48,135,322
(GRCh38/hg38)
Size:
71,819 bases
Orientation:
Minus strand
chr4:48,068,410-48,136,273
(GRCh37/hg19)
Size:
67,864 bases
Orientation:
Minus strand

Genomic View for TXK Gene

Genes around TXK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXK Gene

Proteins for TXK Gene

  • Protein details for TXK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42681-TXK_HUMAN
    Recommended name:
    Tyrosine-protein kinase TXK
    Protein Accession:
    P42681
    Secondary Accessions:
    • Q14220

    Protein attributes for TXK Gene

    Size:
    527 amino acids
    Molecular mass:
    61258 Da
    Quaternary structure:
    • Interacts with PARP1 and EEF1A1. Interacts with SH2D2A (By similarity).

    Three dimensional structures from OCA and Proteopedia for TXK Gene

neXtProt entry for TXK Gene

Selected DME Specific Peptides for TXK Gene

P42681:
  • SSKSDVWSFGVLMWE
  • RDLAARN
  • SDVWSFGVLMWE
  • LVQLYGVC
  • KSDVWSFG
  • TEFMENG
  • NGCLLNYL
  • RLYRPHLA

Post-translational modifications for TXK Gene

  • Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to the up-regulation of IFN-gamma gene transcription.
  • The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TXK Gene

Gene Families for TXK Gene

Protein Domains for TXK Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Tyrosine protein kinase, active site
  • SH3 domain signature
ProtoNet:

Suggested Antigen Peptide Sequences for TXK Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine kinase (Q6LD13_HUMAN)
  • Tyrosine kinase (Q6LD14_HUMAN)
  • Protein-tyrosine kinase 4 (TXK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42681

UniProtKB/Swiss-Prot:

TXK_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
genes like me logo Genes that share domains with TXK: view

Function for TXK Gene

Molecular function for TXK Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation by FYN.
GENATLAS Biochemistry:
protein tyrosine kinase 4,non receptor type,SRC family,Tec subfamily

Enzyme Numbers (IUBMB) for TXK Gene

Phenotypes From GWAS Catalog for TXK Gene

Gene Ontology (GO) - Molecular Function for TXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11859127
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 11859127
GO:0001012 RNA polymerase II regulatory region DNA binding IDA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 11859127
genes like me logo Genes that share ontologies with TXK: view
genes like me logo Genes that share phenotypes with TXK: view

Animal Models for TXK Gene

MGI Knock Outs for TXK:
  • Txk Txk<tm1Pls>
  • Txk Txk<tm2b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for TXK Gene

miRTarBase miRNAs that target TXK

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXK Gene

Localization for TXK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXK Gene

Cytoplasm. Nucleus. Cell membrane. Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXK gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10523612
GO:0005737 cytoplasm IEA,IDA 10523612
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TXK: view

Pathways & Interactions for TXK Gene

PathCards logo

SuperPathways for TXK Gene

SuperPathway Contained pathways
1 ICos-ICosL Pathway in T-Helper Cell
.66
.66
2 Innate Immune System
3 Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling
4 Sweet Taste Signaling
.37
5 Akt Signaling
.55
genes like me logo Genes that share pathways with TXK: view

Pathways by source for TXK Gene

1 KEGG pathway for TXK Gene
5 Qiagen pathways for TXK Gene
  • CD28 Signaling in T-Helper Cell
  • ICos-ICosL Pathway in T-Helper Cell
  • Sperm Motility
  • Tec Kinases Signaling
  • Transendothelial Migration of Leukocytes

SIGNOR curated interactions for TXK Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production ISS --
GO:0002250 adaptive immune response IBA,ISS --
GO:0002376 immune system process IEA --
GO:0006357 regulation of transcription by RNA polymerase II IDA 11859127
GO:0006468 protein phosphorylation IEA,IDA 17177976
genes like me logo Genes that share ontologies with TXK: view

Drugs & Compounds for TXK Gene

(6) Drugs for TXK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Zanubrutinib Approved, Investigational Pharma Target, inhibitor 33
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(2) Additional Compounds for TXK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with TXK: view

Transcripts for TXK Gene

mRNA/cDNA for TXK Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXK

Alternative Splicing Database (ASD) splice patterns (SP) for TXK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: -

Relevant External Links for TXK Gene

GeneLoc Exon Structure for
TXK

Expression for TXK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TXK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXK Gene

This gene is overexpressed in Whole Blood (x12.5), Spleen (x6.5), and Small Intestine - Terminal Ileum (x4.1).

Protein differential expression in normal tissues from HIPED for TXK Gene

This gene is overexpressed in Spleen (55.4) and Brain (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TXK Gene



Protein tissue co-expression partners for TXK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TXK

SOURCE GeneReport for Unigene cluster for TXK Gene:

Hs.479669

mRNA Expression by UniProt/SwissProt for TXK Gene:

P42681-TXK_HUMAN
Tissue specificity: Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential.

Evidence on tissue expression from TISSUES for TXK Gene

  • Blood(4.6)
  • Spleen(2.3)
  • Lymph node(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with TXK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TXK Gene

Orthologs for TXK Gene

This gene was present in the common ancestor of animals.

Orthologs for TXK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TXK 30 31
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TXK 30 31
  • 89.06 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TXK 30 31
  • 87.73 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Txk 30 17 31
  • 81.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Txk 30
  • 81.56 (n)
Oppossum
(Monodelphis domestica)
Mammalia TXK 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 39 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves TXK 30 31
  • 70.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii LOC100534735 30
  • 62.99 (n)
TXK 31
  • 56 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Btk29A 31 32
  • 31 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T21G5.1 32
  • 38 (a)
kin-23 32
  • 35 (a)
spe-8 32
  • 31 (a)
F26E4.5 32
  • 31 (a)
kin-24 32
  • 25 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
ManyToMany
Species where no ortholog for TXK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TXK Gene

ENSEMBL:
Gene Tree for TXK (if available)
TreeFam:
Gene Tree for TXK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TXK: view image

Paralogs for TXK Gene

genes like me logo Genes that share paralogs with TXK: view

Variants for TXK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TXK Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11724347 - p.Arg336Gln
rs41265727 - p.Arg63Cys
rs7658300 - p.Arg45His

Additional dbSNP identifiers (rs#s) for TXK Gene

Structural Variations from Database of Genomic Variants (DGV) for TXK Gene

Variant ID Type Subtype PubMed ID
dgv26e197 CNV deletion 19546169
dgv2788n106 CNV deletion 24896259
esv1207473 CNV deletion 17803354
esv1703195 CNV deletion 17803354
esv2282150 CNV deletion 18987734
esv2727537 CNV deletion 23290073
esv2727538 CNV deletion 23290073
esv2727539 CNV deletion 23290073
esv3050590 CNV deletion 24192839
esv3302729 CNV tandem duplication 20981092
esv989923 CNV insertion 20482838
esv999712 CNV deletion 20482838
nsv1114518 CNV deletion 24896259
nsv1125808 CNV tandem duplication 24896259
nsv1148910 CNV insertion 26484159
nsv292298 CNV deletion 16902084
nsv293505 CNV deletion 16902084
nsv956886 CNV deletion 24416366

Variation tolerance for TXK Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXK Gene

Disorders for TXK Gene

MalaCards: The human disease database

(4) MalaCards diseases for TXK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
agammaglobulinemia
  • hypogammaglobulinemia
behcet syndrome
  • behcet disease; bd
agammaglobulinemia, x-linked
  • xla
dermatitis, atopic
  • atod
- elite association - COSMIC cancer census association via MalaCards
Search TXK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TXK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TXK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXK Gene

Publications for TXK Gene

  1. Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. (PMID: 17177976) Maruyama T … Suzuki N (Clinical and experimental immunology 2007) 3 4 23
  2. Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. (PMID: 11859127) Takeba Y … Suzuki N (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 23
  3. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. (PMID: 10523612) Kashiwakura J … Sakane T (The Journal of experimental medicine 1999) 3 4 23
  4. Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. (PMID: 9813138) Schneider H … Rudd CE (Biochemical and biophysical research communications 1998) 3 4 23
  5. Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene. (PMID: 8632917) Ohta Y … Litman GW (Oncogene 1996) 3 4 23

Products for TXK Gene

Sources for TXK Gene