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TWSG1 (Twisted Gastrulation BMP Signaling Modulator 1) is a Protein Coding gene. Diseases associated with TWSG1 include Breast Papillomatosis and Holoprosencephaly. Among its related pathways are Mesodermal Commitment Pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO:0050431 | transforming growth factor beta binding | IDA | 17164348 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mesodermal Commitment Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001503 | ossification | IEA | -- |
GO:0001707 | mesoderm formation | IEA | -- |
GO:0001818 | negative regulation of cytokine production | IDA | 17164348 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 17164348 |
GO:0007275 | multicellular organism development | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TWSG1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TWSG1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TWSG1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TWSG1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TWSG1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Twsg1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Twsg1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TWSG1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TWSG1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | twsg1 30 |
|
||
Str.1743 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.778 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | twsg1a 30 31 |
|
OneToMany | |
twsg1b 31 |
|
OneToMany | |||
tsga 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1024 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | tsg 30 31 |
|
OneToMany | |
srw 31 |
|
OneToMany | |||
cv 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1546n106 | CNV | deletion | 24896259 |
dgv55n6 | CNV | deletion | 16902084 |
esv2716769 | CNV | deletion | 23290073 |
esv3304810 | CNV | mobile element insertion | 20981092 |
esv3310271 | CNV | mobile element insertion | 20981092 |
esv3332314 | CNV | insertion | 20981092 |
esv3555034 | CNV | deletion | 23714750 |
esv7261 | CNV | loss | 19470904 |
nsv1056407 | CNV | gain | 25217958 |
nsv1069735 | CNV | deletion | 25765185 |
nsv1133243 | CNV | tandem duplication | 24896259 |
nsv1151888 | CNV | deletion | 26484159 |
nsv1160506 | CNV | duplication | 26073780 |
nsv507859 | OTHER | sequence alteration | 20534489 |
nsv576447 | CNV | gain | 21841781 |
nsv833585 | CNV | gain+loss | 17160897 |
nsv954080 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast papillomatosis |
|
|
holoprosencephaly |
|
|
prolapse of urethra |
|
|
anemia, congenital dyserythropoietic, type ia |
|
|
agnathia-otocephaly complex |
|
|