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Aliases for TVP23B Gene

Aliases for TVP23B Gene

  • Trans-Golgi Network Vesicle Protein 23 Homolog B 2 3 5
  • Family With Sequence Similarity 18, Member B1 2 3
  • Family With Sequence Similarity 18, Member B 2 3
  • FAM18B1 3 4
  • FAM18B 3 4
  • Trans-Golgi Network Vesicle Protein 23 Homolog B (S. Cerevisiae) 2
  • Golgi Apparatus Membrane Protein TVP23 Homolog B 3
  • Protein FAM18B1 3
  • YDR084C 3
  • CGI-148 3
  • NPD008 3

External Ids for TVP23B Gene

Previous HGNC Symbols for TVP23B Gene

  • FAM18B
  • FAM18B1

Previous GeneCards Identifiers for TVP23B Gene

  • GC17P018690

Summaries for TVP23B Gene

GeneCards Summary for TVP23B Gene

TVP23B (Trans-Golgi Network Vesicle Protein 23 Homolog B) is a Protein Coding gene. An important paralog of this gene is TVP23C.

Gene Wiki entry for TVP23B Gene

Additional gene information for TVP23B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TVP23B Gene

Genomics for TVP23B Gene

GeneHancer (GH) Regulatory Elements for TVP23B Gene

Promoters and enhancers for TVP23B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I018780 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 621.5 +0.3 314 2.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B TVP23B MAPK7 FOXO3B SMCR8 DRG2 ENSG00000262202 ZNF286B LOC100419436 ENSG00000264885 ENSG00000264932
GH17I018857 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 30.6 +78.4 78375 3.8 HDGF PKNOX1 MLX ARID4B SIN3A IRF4 YY1 ZNF121 GLIS2 ZNF207 PRPSAP2 TVP23B ENSG00000231625 LOC645139 B9D1 FOXO3B ENSG00000264273 RN7SL627P LOC101929141
GH17I018744 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 26.2 -35.3 -35293 3.4 GATAD2A TFE3 FOXA2 SAP130 FOXA3 ZFP64 CHD7 RARA RAD51 NR2F6 FBXW10 TVP23B SHMT1 SMCR8
GH17I018899 Enhancer 1.2 FANTOM5 Ensembl ENCODE 27.3 +119.8 119833 3.1 HDGF PKNOX1 RB1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 PRPSAP2 TVP23B ENSG00000212618 GC17P018891 LOC100419620
GH17I018718 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 19.1 -60.4 -60449 4.9 NEUROD1 ZIC2 CTBP1 ZNF316 SCRT2 PRDM10 NFE2 FOS IKZF2 SRF TRIM16L TVP23B SMCR8 SNORD3B-1 ENSG00000265693 FBXW10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TVP23B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TVP23B Gene

Genomic Locations for TVP23B Gene
chr17:18,780,995-18,806,714
(GRCh38/hg38)
Size:
25,720 bases
Orientation:
Plus strand
chr17:18,684,308-18,710,027
(GRCh37/hg19)

Genomic View for TVP23B Gene

Genes around TVP23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TVP23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TVP23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TVP23B Gene

Proteins for TVP23B Gene

  • Protein details for TVP23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ1-TV23B_HUMAN
    Recommended name:
    Golgi apparatus membrane protein TVP23 homolog B
    Protein Accession:
    Q9NYZ1
    Secondary Accessions:
    • A8K448
    • Q96HK5
    • Q9Y3E6

    Protein attributes for TVP23B Gene

    Size:
    205 amino acids
    Molecular mass:
    23576 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34143.1; Type=Frameshift; Positions=178; Evidence={ECO:0000305};

neXtProt entry for TVP23B Gene

Post-translational modifications for TVP23B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TVP23B Gene

Domains & Families for TVP23B Gene

Gene Families for TVP23B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TVP23B Gene

Suggested Antigen Peptide Sequences for TVP23B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYZ1

UniProtKB/Swiss-Prot:

TV23B_HUMAN :
  • Belongs to the TVP23 family.
Family:
  • Belongs to the TVP23 family.
genes like me logo Genes that share domains with TVP23B: view

Function for TVP23B Gene

Phenotypes for TVP23B Gene

genes like me logo Genes that share phenotypes with TVP23B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TVP23B

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TVP23B Gene

Localization for TVP23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TVP23B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TVP23B gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TVP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with TVP23B: view

Pathways & Interactions for TVP23B Gene

SuperPathways for TVP23B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TVP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IBA --
GO:0016192 vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with TVP23B: view

No data available for Pathways by source and SIGNOR curated interactions for TVP23B Gene

Drugs & Compounds for TVP23B Gene

No Compound Related Data Available

Transcripts for TVP23B Gene

Unigene Clusters for TVP23B Gene

Trans-golgi network vesicle protein 23 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TVP23B Gene

No ASD Table

Relevant External Links for TVP23B Gene

GeneLoc Exon Structure for
TVP23B
ECgene alternative splicing isoforms for
TVP23B

Expression for TVP23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TVP23B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TVP23B Gene:

TVP23B

SOURCE GeneReport for Unigene cluster for TVP23B Gene:

Hs.87295

Evidence on tissue expression from TISSUES for TVP23B Gene

  • Kidney(4)
  • Muscle(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TVP23B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TVP23B Gene

Orthologs for TVP23B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TVP23B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC455050 33
  • 98.86 (n)
TVP23B 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TVP23B 33 34
  • 89.76 (n)
cow
(Bos Taurus)
Mammalia TVP23B 33 34
  • 87.64 (n)
mouse
(Mus musculus)
Mammalia Tvp23b 33 16 34
  • 85.04 (n)
rat
(Rattus norvegicus)
Mammalia Tvp23b 33
  • 84.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM18B1 33 34
  • 75.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 79 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tvp23b 33
  • 70.77 (n)
Str.7026 33
zebrafish
(Danio rerio)
Actinopterygii tvp23b 33 34
  • 67.53 (n)
zgc:112148 34
  • 60 (a)
ManyToMany
Dr.18457 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4385 33
fruit fly
(Drosophila melanogaster)
Insecta CG5021 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_C34D4.4 33
  • 52.1 (n)
C34D4.4 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TVP23 34 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4306 34
  • 51 (a)
OneToMany
Species where no ortholog for TVP23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TVP23B Gene

ENSEMBL:
Gene Tree for TVP23B (if available)
TreeFam:
Gene Tree for TVP23B (if available)

Paralogs for TVP23B Gene

Paralogs for TVP23B Gene

(3) SIMAP similar genes for TVP23B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TVP23B Gene

genes like me logo Genes that share paralogs with TVP23B: view

Variants for TVP23B Gene

Sequence variations from dbSNP and Humsavar for TVP23B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000226487 -- 18,801,334(+) G/T intron_variant
rs1000587913 -- 18,788,288(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000618941 -- 18,788,054(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000768770 -- 18,794,287(+) T/C intron_variant
rs1001138923 -- 18,794,720(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TVP23B Gene

Variant ID Type Subtype PubMed ID
dgv564e214 CNV gain 21293372
nsv1055999 CNV gain 25217958
nsv1057803 CNV loss 25217958
nsv1063354 CNV gain 25217958
nsv1076440 CNV duplication 25765185
nsv442413 CNV gain 18776908
nsv499818 OTHER inversion 21111241
nsv523721 CNV gain 19592680
nsv833389 CNV gain 17160897
nsv833390 CNV loss 17160897
nsv9504 CNV gain+loss 18304495
nsv960431 CNV duplication 23825009
nsv978381 CNV duplication 23825009

Variation tolerance for TVP23B Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TVP23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TVP23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TVP23B Gene

Disorders for TVP23B Gene

Additional Disease Information for TVP23B

No disorders were found for TVP23B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TVP23B Gene

Publications for TVP23B Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  4. Role of FAM18B in diabetic retinopathy. (PMID: 25221423) Wang AL … Grassi MA (Molecular vision 2014) 3 58
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 58

Products for TVP23B Gene

Sources for TVP23B Gene

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