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This gene encodes a membrane protein associated with the Golgi apparatus, which plays a crucial role in intracellular vesicular transport. The encoded protein is likely associated with the late (trans) Golgi compartments, which are involved in the delivery of secretory and membrane proteins to the endosome, lysosome or the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
TVP23A (Trans-Golgi Network Vesicle Protein 23 Homolog A) is a Protein Coding gene. Diseases associated with TVP23A include Atrial Septal Defect 3 and Pachyonychia Congenita 1. An important paralog of this gene is TVP23B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 32296183 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030173 | integral component of Golgi membrane | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009306 | protein secretion | IBA | 21873635 |
GO:0016192 | vesicle-mediated transport | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TVP23A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TVP23A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TVP23A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tvp23a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tvp23a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TVP23A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | FAM18A 30 |
|
||
TVP23A 31 |
|
OneToOne | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tvp23a 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5021 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012432 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | C34D4.4 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C11869g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TVP23 30 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR153C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G09330 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0331900 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU02733 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tvp23 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4306 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2204919 | CNV | deletion | 18987734 |
esv2678178 | CNV | deletion | 23128226 |
esv2713976 | CNV | deletion | 23290073 |
esv2763131 | CNV | loss | 21179565 |
esv3637915 | CNV | loss | 21293372 |
nsv1040428 | CNV | gain | 25217958 |
nsv1071264 | CNV | deletion | 25765185 |
nsv833140 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
atrial septal defect 3 |
|
|
pachyonychia congenita 1 |
|
|