Free for academic non-profit institutions. Other users need a Commercial license
ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]
TUT4 (Terminal Uridylyl Transferase 4) is a Protein Coding gene. Diseases associated with TUT4 include Perlman Syndrome and Renal Wilms' Tumor. An important paralog of this gene is TUT7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004652 | polynucleotide adenylyltransferase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 19703396 |
GO:0008270 | zinc ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 22664934 |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 19703396 |
GO:0005829 | cytosol | IDA,TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | -- |
GO:0001556 | oocyte maturation | ISS | -- |
GO:0001816 | cytokine production | IEA | -- |
GO:0006378 | mRNA polyadenylation | IBA | 21873635 |
GO:0006397 | mRNA processing | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Uridine triphosphate | Experimental, Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZCCHC11 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZCCHC11 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LOC528986 30 |
|
||
ZCCHC11 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Zcchc11 30 31 |
|
OneToOne | |
Tut4 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Zcchc11 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ZCCHC11 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZCCHC11 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZCCHC11 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZCCHC11 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zcchc11 30 |
|
||
Str.15797 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | LOC795358 30 |
|
||
zcchc11 31 |
|
OneToOne | |||
Dr.17857 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | mkg-p 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | pup-2 31 |
|
ManyToMany | |
cid-1 31 |
|
ManyToMany | |||
Y34F4.3 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5065 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4240 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
719704 | Benign: not provided | 52,461,743(-) | T/C | SYNONYMOUS_VARIANT | |
719705 | Benign: not provided | 52,525,715(-) | G/A | MISSENSE_VARIANT | |
769514 | Benign: not provided | 52,475,173(-) | C/A | MISSENSE_VARIANT | |
780240 | Benign: not provided | 52,525,897(-) | T/C | SYNONYMOUS_VARIANT | |
791794 | Benign: not provided | 52,461,623(-) | T/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3586051 | CNV | loss | 21293372 |
esv988243 | CNV | insertion | 20482838 |
nsv1137759 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
perlman syndrome |
|
|
renal wilms' tumor |
|
|
cardiomyopathy, familial hypertrophic, 13 |
|
|
diffuse lipomatosis |
|
|