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Aliases for TUSC5 Gene

Aliases for TUSC5 Gene

  • Tumor Suppressor Candidate 5 2 3 5
  • Dispanin Subfamily B Member 1 2 3 4
  • Interferon-Induced Transmembrane Domain-Containing Protein D3 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 3 2 3
  • Protein Located At Seventeen-P-Thirteen Point Three 1 3 4
  • Located At Seventeen P Thirteen Point Three 1 2 3
  • Brain Endothelial Cell Derived Gene-1 2 3
  • IFITMD3 3 4
  • DSPB1 3 4
  • LOST1 3 4
  • BEC-1 3

External Ids for TUSC5 Gene

Previous GeneCards Identifiers for TUSC5 Gene

  • GC17P001390
  • GC17P001129
  • GC17P001182

Summaries for TUSC5 Gene

GeneCards Summary for TUSC5 Gene

TUSC5 (Tumor Suppressor Candidate 5) is a Protein Coding gene. Diseases associated with TUSC5 include Accommodative Esotropia and Chiasmal Syndrome. An important paralog of this gene is PRRT2.

UniProtKB/Swiss-Prot for TUSC5 Gene

  • May be involved in fat metabolism.

Additional gene information for TUSC5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUSC5 Gene

Genomics for TUSC5 Gene

GeneHancer (GH) Regulatory Elements for TUSC5 Gene

Promoters and enhancers for TUSC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I001279 Promoter/Enhancer 1 EPDnew dbSUPER 550.8 0.0 -20 0.1 KLF1 GLIS1 ZSCAN4 KLF17 ZNF398 ZIC2 TUSC5 BHLHA9
GH17I001258 Enhancer 1.2 Ensembl ENCODE 12.6 -20.2 -20160 1.8 SIN3A ZNF2 ZNF213 ZNF416 ZNF207 ZNF143 ZNF548 KLF13 SP3 ZC3H11A PRPF8 SMYD4 WDR81 RPA1 GEMIN4 ENSG00000262228 DPH1 ENSG00000262920 MYO1C HIC1
GH17I001484 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.8 +209.0 208993 9.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF213 MYO1C PITPNA PRPF8 WDR81 SMYD4 GEMIN4 DPH1 YWHAE ENSG00000262228 INPP5K
GH17I001253 Promoter/Enhancer 1.2 Ensembl ENCODE 12.3 -25.8 -25819 0.7 BCOR HDAC1 MEIS2 CHD4 SIN3A ZBTB40 CTBP1 MTA3 POLR2A HSF1 ENSG00000262213 GC17M001250 TUSC5 ABR ENSG00000235361 YWHAE MYO1C INPP5K SLC43A2
GH17I001313 Enhancer 0.7 FANTOM5 dbSUPER 14.8 +34.1 34110 0.3 IKZF1 CEBPA CEBPB GC17M001298 TUSC5 TLCD2 GC17P001285
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TUSC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUSC5 gene promoter:

Genomic Locations for TUSC5 Gene

Genomic Locations for TUSC5 Gene
21,325 bases
Plus strand

Genomic View for TUSC5 Gene

Genes around TUSC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUSC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUSC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC5 Gene

Proteins for TUSC5 Gene

  • Protein details for TUSC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor suppressor candidate 5
    Protein Accession:
    Secondary Accessions:
    • A6NMK4

    Protein attributes for TUSC5 Gene

    177 amino acids
    Molecular mass:
    19254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUSC5 Gene

Post-translational modifications for TUSC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUSC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUSC5 Gene

Domains & Families for TUSC5 Gene

Gene Families for TUSC5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TUSC5 Gene

Suggested Antigen Peptide Sequences for TUSC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD225/Dispanin family.
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TUSC5: view

Function for TUSC5 Gene

Molecular function for TUSC5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fat metabolism.

Phenotypes From GWAS Catalog for TUSC5 Gene

genes like me logo Genes that share phenotypes with TUSC5: view

Animal Models for TUSC5 Gene

MGI Knock Outs for TUSC5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TUSC5 Gene

Localization for TUSC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUSC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUSC5 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TUSC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with TUSC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TUSC5 Gene

Pathways & Interactions for TUSC5 Gene

SuperPathways for TUSC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TUSC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009607 response to biotic stimulus IEA --
GO:0032869 cellular response to insulin stimulus IEA --
GO:0044381 glucose import in response to insulin stimulus IEA --
GO:0045026 plasma membrane fusion IEA --
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with TUSC5: view

No data available for Pathways by source and SIGNOR curated interactions for TUSC5 Gene

Drugs & Compounds for TUSC5 Gene

No Compound Related Data Available

Transcripts for TUSC5 Gene

mRNA/cDNA for TUSC5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUSC5 Gene

Tumor suppressor candidate 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC5 Gene

No ASD Table

Relevant External Links for TUSC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUSC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUSC5 Gene

mRNA differential expression in normal tissues according to GTEx for TUSC5 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x17.1), Adipose - Subcutaneous (x15.4), and Breast - Mammary Tissue (x8.9).

Protein differential expression in normal tissues from HIPED for TUSC5 Gene

This gene is overexpressed in Adipocyte (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TUSC5 Gene

Protein tissue co-expression partners for TUSC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TUSC5 Gene:


SOURCE GeneReport for Unigene cluster for TUSC5 Gene:


mRNA Expression by UniProt/SwissProt for TUSC5 Gene:

Tissue specificity: Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.

Evidence on tissue expression from TISSUES for TUSC5 Gene

  • Lung(4)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with TUSC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUSC5 Gene

Orthologs for TUSC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TUSC5 33 34
  • 97.55 (n)
(Canis familiaris)
Mammalia TUSC5 33 34
  • 82.49 (n)
(Rattus norvegicus)
Mammalia Tusc5 33
  • 82.08 (n)
(Bos Taurus)
Mammalia TUSC5 33 34
  • 81.92 (n)
(Mus musculus)
Mammalia Tusc5 33 16 34
  • 81.31 (n)
(Monodelphis domestica)
Mammalia TUSC5 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TUSC5 34
  • 51 (a)
(Gallus gallus)
Aves TUSC5 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tusc5 33
  • 62.03 (n)
(Danio rerio)
Actinopterygii LOC101886018 33
  • 53.83 (n)
TUSC5 34
  • 34 (a)
Species where no ortholog for TUSC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUSC5 Gene

Gene Tree for TUSC5 (if available)
Gene Tree for TUSC5 (if available)

Paralogs for TUSC5 Gene

Paralogs for TUSC5 Gene

(1) SIMAP similar genes for TUSC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TUSC5: view

Variants for TUSC5 Gene

Sequence variations from dbSNP and Humsavar for TUSC5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000133556 -- 1,282,090(+) A/G intron_variant
rs1000266700 -- 1,278,191(+) G/A upstream_transcript_variant
rs1000464562 -- 1,282,043(+) T/C intron_variant
rs1000882086 -- 1,301,114(+) G/A downstream_transcript_variant
rs1000904748 -- 1,278,851(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TUSC5 Gene

Variant ID Type Subtype PubMed ID
dgv3080n100 CNV gain 25217958
dgv3081n100 CNV gain 25217958
esv1777284 CNV deletion 17803354
esv2715442 CNV deletion 23290073
esv2715443 CNV deletion 23290073
esv2715444 CNV deletion 23290073
esv2715445 CNV deletion 23290073
esv2761939 CNV loss 21179565
esv3639678 CNV loss 21293372
esv3639679 CNV loss 21293372
esv6254 CNV gain 19470904
nsv1064006 CNV gain 25217958
nsv1071360 CNV deletion 25765185
nsv1118745 CNV deletion 24896259
nsv1125200 CNV insertion 24896259
nsv1131127 CNV deletion 24896259
nsv1131290 CNV deletion 24896259
nsv1147091 CNV insertion 26484159
nsv509645 CNV insertion 20534489
nsv952097 CNV deletion 24416366

Variation tolerance for TUSC5 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUSC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUSC5 Gene

Disorders for TUSC5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TUSC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
accommodative esotropia
  • esotropia with accommodative compensation
chiasmal syndrome
  • chiasma syndrome
regular astigmatism
miller-dieker lissencephaly syndrome
  • mdls
- elite association - COSMIC cancer census association via MalaCards
Search TUSC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUSC5

genes like me logo Genes that share disorders with TUSC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUSC5 Gene

Publications for TUSC5 Gene

  1. Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer. (PMID: 12660825) Konishi H … Takahashi T (Oncogene 2003) 2 3 4 58
  2. TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. (PMID: 26629404) Beaton N … Wolfrum C (Molecular metabolism 2015) 2 3 58
  3. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TUSC5 Gene

Sources for TUSC5 Gene

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