This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008] See more...

Aliases for TUSC2 Gene

Aliases for TUSC2 Gene

  • Tumor Suppressor 2, Mitochondrial Calcium Regulator 2 3 5
  • Tumor Suppressor Candidate 2 2 3 4
  • PDGFA-Associated Protein 2 3 4
  • Fusion 1 Protein 3 4
  • Fus-1 Protein 3 4
  • C3orf11 3 4
  • PDAP2 3 4
  • FUS1 3 4
  • PDGFA Associated Protein 2 2
  • LGCC 4
  • PAP 3

External Ids for TUSC2 Gene

Previous HGNC Symbols for TUSC2 Gene

  • PDAP2

Previous GeneCards Identifiers for TUSC2 Gene

  • GC03M050321
  • GC03M050338
  • GC03M050357
  • GC03M050328

Summaries for TUSC2 Gene

Entrez Gene Summary for TUSC2 Gene

  • This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUSC2 Gene

TUSC2 (Tumor Suppressor 2, Mitochondrial Calcium Regulator) is a Protein Coding gene. Diseases associated with TUSC2 include Lung Cancer.

UniProtKB/Swiss-Prot Summary for TUSC2 Gene

  • May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Gene Wiki entry for TUSC2 Gene

Additional gene information for TUSC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUSC2 Gene

Genomics for TUSC2 Gene

GeneHancer (GH) Regulatory Elements for TUSC2 Gene

Promoters and enhancers for TUSC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUSC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUSC2

Top Transcription factor binding sites by QIAGEN in the TUSC2 gene promoter:
  • AP-1
  • ATF-2

Genomic Locations for TUSC2 Gene

Genomic Locations for TUSC2 Gene
chr3:50,320,027-50,328,251
(GRCh38/hg38)
Size:
8,225 bases
Orientation:
Minus strand
chr3:50,357,458-50,365,682
(GRCh37/hg19)
Size:
8,225 bases
Orientation:
Minus strand

Genomic View for TUSC2 Gene

Genes around TUSC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUSC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUSC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC2 Gene

Proteins for TUSC2 Gene

  • Protein details for TUSC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75896-TUSC2_HUMAN
    Recommended name:
    Tumor suppressor candidate 2
    Protein Accession:
    O75896
    Secondary Accessions:
    • B2R4Y9

    Protein attributes for TUSC2 Gene

    Size:
    110 amino acids
    Molecular mass:
    12074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUSC2 Gene

Post-translational modifications for TUSC2 Gene

Other Protein References for TUSC2 Gene

No data available for DME Specific Peptides for TUSC2 Gene

Domains & Families for TUSC2 Gene

Gene Families for TUSC2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TUSC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TUSC2 Gene

GenScript: Design optimal peptide antigens:
  • PDGFA-associated protein 2 (TUSC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75896

UniProtKB/Swiss-Prot:

TUSC2_HUMAN :
  • Belongs to the TUSC2 family.
Family:
  • Belongs to the TUSC2 family.
genes like me logo Genes that share domains with TUSC2: view

Function for TUSC2 Gene

Molecular function for TUSC2 Gene

UniProtKB/Swiss-Prot Function:
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Phenotypes From GWAS Catalog for TUSC2 Gene

Gene Ontology (GO) - Molecular Function for TUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TUSC2: view
genes like me logo Genes that share phenotypes with TUSC2: view

Animal Models for TUSC2 Gene

MGI Knock Outs for TUSC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUSC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TUSC2 Gene

Localization for TUSC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUSC2 gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA 21873635
genes like me logo Genes that share ontologies with TUSC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TUSC2 Gene

Pathways & Interactions for TUSC2 Gene

PathCards logo

SuperPathways for TUSC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0006909 phagocytosis IEA --
GO:0006954 inflammatory response IBA,IEA 21873635
GO:0007049 cell cycle IEA --
GO:0032618 interleukin-15 production IEA --
genes like me logo Genes that share ontologies with TUSC2: view

No data available for Pathways by source and SIGNOR curated interactions for TUSC2 Gene

Drugs & Compounds for TUSC2 Gene

(1) Drugs for TUSC2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DOTAP:chol-FUS1 Pharma Others 0
genes like me logo Genes that share compounds with TUSC2: view

Transcripts for TUSC2 Gene

mRNA/cDNA for TUSC2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUSC2

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -
SP4: - - -
SP5:

Relevant External Links for TUSC2 Gene

GeneLoc Exon Structure for
TUSC2

Expression for TUSC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUSC2 Gene

Protein differential expression in normal tissues from HIPED for TUSC2 Gene

This gene is overexpressed in Fetal Brain (28.9), Fetal testis (22.6), and Spinal cord (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUSC2 Gene



Protein tissue co-expression partners for TUSC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUSC2

SOURCE GeneReport for Unigene cluster for TUSC2 Gene:

Hs.517981

mRNA Expression by UniProt/SwissProt for TUSC2 Gene:

O75896-TUSC2_HUMAN
Tissue specificity: Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.

Evidence on tissue expression from TISSUES for TUSC2 Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TUSC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUSC2 Gene

Orthologs for TUSC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUSC2 31 30
  • 99.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TUSC2 31 30
  • 92.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tusc2 30
  • 90 (n)
mouse
(Mus musculus)
Mammalia Tusc2 17 31 30
  • 88.79 (n)
dog
(Canis familiaris)
Mammalia TUSC2 31
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUSC2 31
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUSC2 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUSC2 31 30
  • 83.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUSC2 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tusc2 30
  • 67.92 (n)
Str.5198 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68809 30
zebrafish
(Danio rerio)
Actinopterygii tusc2a 31 30
  • 65.15 (n)
OneToMany
tusc2b 31
  • 65 (a)
OneToMany
Dr.15528 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.974 30
Species where no ortholog for TUSC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUSC2 Gene

ENSEMBL:
Gene Tree for TUSC2 (if available)
TreeFam:
Gene Tree for TUSC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUSC2: view image

Paralogs for TUSC2 Gene

No data available for Paralogs for TUSC2 Gene

Variants for TUSC2 Gene

Additional dbSNP identifiers (rs#s) for TUSC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TUSC2 Gene

Variant ID Type Subtype PubMed ID
dgv8317n54 CNV loss 21841781
esv2759148 CNV loss 17122850
esv3584502 CNV gain 24956385
nsv3813 CNV deletion 18451855
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for TUSC2 Gene

Gene Damage Index Score: 0.04; 0.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUSC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUSC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUSC2 Gene

Disorders for TUSC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUSC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search TUSC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUSC2

genes like me logo Genes that share disorders with TUSC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUSC2 Gene

Publications for TUSC2 Gene

  1. Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells. (PMID: 11593436) Kondo M … Minna JD (Oncogene 2001) 2 3 4 23 54
  2. Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells. (PMID: 15126327) Uno F … Ji L (Cancer research 2004) 3 4 23 54
  3. Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. (PMID: 18172250) Prudkin L … Wistuba II (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for TUSC2 Gene

Sources for TUSC2 Gene