This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008] See more...

Aliases for TUSC1 Gene

Aliases for TUSC1 Gene

  • Tumor Suppressor Candidate 1 2 3 5
  • Tumor Suppressor Candidate Gene 1 Protein 3 4
  • TSG-9 3 4
  • TSG9 3 4
  • CCDC89B 3

External Ids for TUSC1 Gene

Previous GeneCards Identifiers for TUSC1 Gene

  • GC09U900702

Summaries for TUSC1 Gene

Entrez Gene Summary for TUSC1 Gene

  • This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUSC1 Gene

TUSC1 (Tumor Suppressor Candidate 1) is a Protein Coding gene. Diseases associated with TUSC1 include Lung Cancer.

Additional gene information for TUSC1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUSC1 Gene

Genomics for TUSC1 Gene

GeneHancer (GH) Regulatory Elements for TUSC1 Gene

Promoters and enhancers for TUSC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J025676 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 512.8 +1.1 1144 3 PHF8 ZFX ZIC2 POLR2A CLOCK ZNF423 ZBTB26 HDAC2 SREBF2 MYC TUSC1 lnc-IFT74-9-001 lnc-IFT74-9-002 piR-52794-007
GH09J025681 Enhancer 0.5 Ensembl 13.3 -2.5 -2543 0.4 FOS EP300 CEBPB JUND BHLHE40 STAT3 TUSC1 lnc-IFT74-9-002 HSALNG0070493
GH09J025396 Enhancer 0.6 Ensembl ENCODE 5.7 +281.6 281613 2.3 GATA2 CHD7 EP300 POU5F1 NANOG TUSC1 HSALNG0070484 hsa-miR-5096-150
GH09J025674 Enhancer 0.3 Ensembl 10.9 +4.2 4157 1 FOXA1 piR-52324-066 piR-52794-007 TUSC1
GH09J025518 Enhancer 0.5 ENCODE 4.5 +159.5 159520 1.8 ZNF217 CTBP1 NEUROD1 FOXA1 DPF2 ESR1 GATA3 SMARCE1 TUSC1 piR-51006-015 LOC105375996
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUSC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUSC1

Top Transcription factor binding sites by QIAGEN in the TUSC1 gene promoter:
  • AML1a
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • CREB
  • Nkx6-1
  • NRF-2

Genomic Locations for TUSC1 Gene

Genomic Locations for TUSC1 Gene
chr9:25,676,389-25,678,858
(GRCh38/hg38)
Size:
2,470 bases
Orientation:
Minus strand
chr9:25,676,387-25,678,856
(GRCh37/hg19)
Size:
2,470 bases
Orientation:
Minus strand

Genomic View for TUSC1 Gene

Genes around TUSC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUSC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUSC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC1 Gene

Proteins for TUSC1 Gene

  • Protein details for TUSC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAM9-TUSC1_HUMAN
    Recommended name:
    Tumor suppressor candidate gene 1 protein
    Protein Accession:
    Q2TAM9
    Secondary Accessions:
    • A0PJ78
    • Q67GI3
    • Q86SS1
    • Q8TAH8

    Protein attributes for TUSC1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23390 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO38227.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TUSC1 Gene

Post-translational modifications for TUSC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUSC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUSC1 Gene

Domains & Families for TUSC1 Gene

Gene Families for TUSC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUSC1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TUSC1 Gene

GenScript: Design optimal peptide antigens:
  • TSG-9 (TUSC1_HUMAN)
genes like me logo Genes that share domains with TUSC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TUSC1 Gene

Function for TUSC1 Gene

Phenotypes From GWAS Catalog for TUSC1 Gene

genes like me logo Genes that share phenotypes with TUSC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUSC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUSC1 Gene

Localization for TUSC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUSC1 gene
Compartment Confidence
nucleus 3
plasma membrane 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TUSC1 Gene

Pathways & Interactions for TUSC1 Gene

PathCards logo

SuperPathways for TUSC1 Gene

No Data Available

Interacting Proteins for TUSC1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000350716 Q2TAM9-TUSC1_HUMAN for TUSC1 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TUSC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TUSC1 Gene

Drugs & Compounds for TUSC1 Gene

No Compound Related Data Available

Transcripts for TUSC1 Gene

mRNA/cDNA for TUSC1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUSC1

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC1 Gene

No ASD Table

Relevant External Links for TUSC1 Gene

GeneLoc Exon Structure for
TUSC1

Expression for TUSC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUSC1 Gene

Protein differential expression in normal tissues from HIPED for TUSC1 Gene

This gene is overexpressed in Liver, secretome (37.9), Neutrophil (24.8), and Adipocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TUSC1 Gene



Protein tissue co-expression partners for TUSC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUSC1

SOURCE GeneReport for Unigene cluster for TUSC1 Gene:

Hs.26268

mRNA Expression by UniProt/SwissProt for TUSC1 Gene:

Q2TAM9-TUSC1_HUMAN
Tissue specificity: Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.
genes like me logo Genes that share expression patterns with TUSC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUSC1 Gene

Orthologs for TUSC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUSC1 31 30
  • 97.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TUSC1 31 30
  • 85.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tusc1 17 31 30
  • 76.91 (n)
oppossum
(Monodelphis domestica)
Mammalia TUSC1 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUSC1 31
  • 43 (a)
OneToOne
Species where no ortholog for TUSC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TUSC1 Gene

ENSEMBL:
Gene Tree for TUSC1 (if available)
TreeFam:
Gene Tree for TUSC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUSC1: view image

Paralogs for TUSC1 Gene

No data available for Paralogs for TUSC1 Gene

Variants for TUSC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUSC1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs34498078 - p.Asn123Asp

Additional dbSNP identifiers (rs#s) for TUSC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TUSC1 Gene

Variant ID Type Subtype PubMed ID
esv3573179 CNV loss 25503493
nsv613889 CNV gain 21841781
nsv613912 CNV loss 21841781
nsv824893 CNV gain 20364138
nsv831530 CNV gain 17160897

Variation tolerance for TUSC1 Gene

Gene Damage Index Score: 4.62; 65.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUSC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUSC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUSC1 Gene

Disorders for TUSC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUSC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search TUSC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUSC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TUSC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUSC1 Gene

Publications for TUSC1 Gene

  1. Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer. (PMID: 15208665) Shan Z … Wiest JS (Oncogene 2004) 2 3 4 23 54
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 41 54
  3. Combined treatment of human multiple myeloma cells with bortezomib and doxorubicin alters the interactome of 20S proteasomes. (PMID: 30009671) Mittenberg AG … Barlev NA (Cell cycle (Georgetown, Tex.) 2018) 3 54
  4. Association of TUSC1 and DPF3 gene polymorphisms with male infertility. (PMID: 28975488) Sato Y … Iwamoto T (Journal of assisted reproduction and genetics 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TUSC1 Gene

Sources for TUSC1 Gene