This gene produces a spliced long non-coding RNA that may play a role in maintaining pluripotency and the neural differentiation of embryonic stem cells. Expression of this lncRNA in the caudate nucleus of brains from Huntington's Disease patients has been found to decrease as the disease progresses. It has also been suggested that this transcript may play a role in the progres... See more...

Aliases for TUNAR Gene

Subcategory (RNA class) for TUNAR Gene

lncRNA

Aliases for TUNAR Gene

External Ids for TUNAR Gene

Previous HGNC Symbols for TUNAR Gene

  • LINC00617

Previous GeneCards Identifiers for TUNAR Gene

  • GC14P096345

Summaries for TUNAR Gene

Entrez Gene Summary for TUNAR Gene

  • This gene produces a spliced long non-coding RNA that may play a role in maintaining pluripotency and the neural differentiation of embryonic stem cells. Expression of this lncRNA in the caudate nucleus of brains from Huntington's Disease patients has been found to decrease as the disease progresses. It has also been suggested that this transcript may play a role in the progression of breast cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Aug 2015]

GeneCards Summary for TUNAR Gene

TUNAR (TCL1 Upstream Neural Differentiation-Associated RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TUNAR include Huntington Disease and Glioma.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUNAR Gene

Genomics for TUNAR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TUNAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J095877 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 256.7 +0.4 444 1.8 ZBTB10 CTCF ZIC2 SIN3A ZNF341 ZNF2 TAF1 ZNF398 ZNF561 ZBTB7A TUNAR HSALNG0103466 C14orf132 TCL1A
GH14J095715 Promoter/Enhancer 0.5 EPDnew dbSUPER 250.1 -160.8 -160798 0.1 TCL1A TUNAR ENSG00000257275 LOC107984703 piR-30350-026 C14orf132
GH14J095891 Enhancer 0.8 Ensembl ENCODE 0.4 +15.7 15748 0.8 EP300 CTBP1 FOSL1 USF2 JUND ZNF589 CEBPG ATF4 ATF3 RFX1 TUNAR HSALNG0103466 C14orf132 TCL1A
GH14J095896 Enhancer 0.7 Ensembl ENCODE 0.3 +20.5 20543 1.6 CTCF SIN3A SMC3 YY1 RAD21 USF2 MAX RAD51 MNT ZNF143 HSALNG0103466 TUNAR C14orf132 TCL1A
GH14J095895 Enhancer 0.6 ENCODE 0.4 +19.6 19632 0.2 CTCF SIN3A SMC3 YY1 RAD21 USF2 MAX PKNOX1 RAD51 MNT TUNAR HSALNG0103466 C14orf132 TCL1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUNAR on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TUNAR Gene

Latest Assembly
chr14:95,876,257-95,925,663
(GRCh38/hg38)
Size:
49,407 bases
Orientation:
Plus strand

Previous Assembly
chr14:96,342,729-96,391,908
(GRCh37/hg19 by Entrez Gene)
Size:
49,180 bases
Orientation:
Plus strand

chr14:96,342,729-96,391,908
(GRCh37/hg19 by Ensembl)
Size:
49,180 bases
Orientation:
Plus strand

Genomic View for TUNAR Gene

Genes around TUNAR on UCSC Golden Path with GeneCards custom track
TUNAR in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
TUNAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUNAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUNAR Gene

Proteins for TUNAR Gene

  • Protein details for TUNAR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GTB2-A0A1B0GTB2_HUMAN
    Recommended name:
    HCG2038094, isoform CRA_a
    Protein Accession:
    A0A1B0GTB2
    Secondary Accessions:
    • A0A1B0GUV0

    Protein attributes for TUNAR Gene

    Size:
    48 amino acids
    Molecular mass:
    5360 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUNAR Gene

Post-translational modifications for TUNAR Gene

No Post-translational modifications

Other Protein References for TUNAR Gene

No data available for DME Specific Peptides for TUNAR Gene

Domains & Families for TUNAR Gene

Gene Families for TUNAR Gene

Protein Domains for TUNAR Gene

ProtoNet:
genes like me logo Genes that share domains with TUNAR: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TUNAR Gene

Function for TUNAR Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TUNAR Gene

Localization for TUNAR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUNAR gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TUNAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TUNAR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TUNAR Gene

Pathways & Interactions for TUNAR Gene

PathCards logo

SuperPathways for TUNAR Gene

No Data Available

Gene Ontology (GO) - Biological Process for TUNAR Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for TUNAR Gene

Drugs & Compounds for TUNAR Gene

No Compound Related Data Available

Transcripts for TUNAR Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for TUNAR Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00008E3A31_9606 lncRNA 3330 1

RefSeq: NR_132398,

URS000075CAB8_9606 lncRNA 3197 1

RefSeq: NR_038861,

URS00008E3A2D_9606 lncRNA 2939 1

RefSeq: NR_132399,

URS000056D6BA_9606 lncRNA 767 2

LncBook: HSALNT0215285,

NONCODE: NONHSAT039500.2,

URS0000D5BFCB_9606 lncRNA 22278 1

LNCipedia: lnc-TUNAR-1:2,

TUNAR in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for TUNAR Gene

5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TUNAR Gene

No ASD Table

Relevant External Links for TUNAR Gene

GeneLoc Exon Structure for
TUNAR

Expression for TUNAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUNAR Gene

mRNA differential expression in normal tissues according to GTEx for TUNAR Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x12.7), Brain - Caudate (basal ganglia) (x9.6), and Brain - Nucleus accumbens (basal ganglia) (x7.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUNAR

genes like me logo Genes that share expression patterns with TUNAR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUNAR Gene

Orthologs for TUNAR Gene

Evolution for TUNAR Gene

ENSEMBL:
Gene Tree for TUNAR (if available)
TreeFam:
Gene Tree for TUNAR (if available)

No data available for Orthologs for TUNAR Gene

Paralogs for TUNAR Gene

No data available for Paralogs for TUNAR Gene

Variants for TUNAR Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TUNAR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TUNAR Gene

Variant ID Type Subtype PubMed ID
esv3581398 CNV loss 25503493
nsv1046191 CNV gain 25217958
nsv1414 CNV insertion 18451855
nsv509547 CNV insertion 20534489

Additional Variant Information for TUNAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUNAR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TUNAR Gene

Disorders for TUNAR Gene

MalaCards: The human disease database

(3) MalaCards diseases for TUNAR Gene - From: LNC and COP

Disorder Aliases PubMed IDs
huntington disease
  • hd
glioma
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search TUNAR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUNAR

genes like me logo Genes that share disorders with TUNAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUNAR Gene

Publications for TUNAR Gene

  1. An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. (PMID: 24530304) Lin N … Rana TM (Molecular cell 2014) 2 3 74
  2. [ARTICLE WITHDRAWN] Long Noncoding RNA TUNAR Represses Growth, Migration, and Invasion of Human Glioma Cells Through Regulating miR-200a and Rac1. (PMID: 29540255) Dai J … Hu Y (Oncology research 2018) 3 74
  3. Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer. (PMID: 26207516) Li H … Sheng Y (Molecular carcinogenesis 2017) 3 74
  4. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. (PMID: 23040067) Morán I … Ferrer J (Cell metabolism 2012) 2 3
  5. Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. (PMID: 22196729) Ulitsky I … Bartel DP (Cell 2011) 2 3

Products for TUNAR Gene

Sources for TUNAR Gene