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Aliases for TULP2 Gene

Aliases for TULP2 Gene

  • Tubby Like Protein 2 2 3 5
  • Cancer/Testis Antigen 65 2 4
  • TUBL2 3 4
  • CT65 3 4
  • Cancer Testis Antigen 65 3
  • Tubby-Related Protein 2 3
  • Tubby-Like Protein 2 4

External Ids for TULP2 Gene

Previous GeneCards Identifiers for TULP2 Gene

  • GC19M050042
  • GC19M049751
  • GC19M054060
  • GC19M054076
  • GC19M049384
  • GC19M045760

Summaries for TULP2 Gene

Entrez Gene Summary for TULP2 Gene

  • TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. [provided by RefSeq, Jul 2008]

GeneCards Summary for TULP2 Gene

TULP2 (Tubby Like Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein complex binding. An important paralog of this gene is TUB.

Additional gene information for TULP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TULP2 Gene

Genomics for TULP2 Gene

GeneHancer (GH) Regulatory Elements for TULP2 Gene

Promoters and enhancers for TULP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I048898 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 567.6 -0.1 -58 3.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 NUCB1 TULP2 PPP1R15A PLEKHA4 BAX FTL DBP SEC1P IRF3 NUCB1-AS1
GH19I048871 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 17.7 +24.2 24169 8.8 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 GC19M048876 PPP1R15A PRR12 SNRNP70 IRF3 GRWD1 SNORD35A PTOV1-AS2 SNORD35B PIH1D1
GH19I048958 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -63.8 -63845 10.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 FTL ENSG00000267898 GC19P048966 GC19P048967 NUP62 PTOV1-AS2 IRF3 PRR12 SNORD35A SNORD35B
GH19I048988 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.4 -91.9 -91869 7.2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B RUVBL2 GYS1 NUP62 GRWD1 PTOV1-AS2 SNORD35A ENSG00000268047 IRF3 SNORD35B SNRNP70
GH19I048809 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 +88.3 88273 4.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B E2F8 BCAT2 HSD17B14 PRR12 IZUMO1 RASIP1 NUCB1 TULP2 SNRNP70 SNORD35A LOC105372432
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TULP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TULP2 gene promoter:

Genomic Locations for TULP2 Gene

Genomic Locations for TULP2 Gene
19,363 bases
Minus strand

Genomic View for TULP2 Gene

Genes around TULP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TULP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TULP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TULP2 Gene

Proteins for TULP2 Gene

  • Protein details for TULP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubby-related protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8TC50

    Protein attributes for TULP2 Gene

    520 amino acids
    Molecular mass:
    58664 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TULP2 Gene

Post-translational modifications for TULP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TULP2 Gene

Domains & Families for TULP2 Gene

Gene Families for TULP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TULP2 Gene

Suggested Antigen Peptide Sequences for TULP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TUB family.
  • Belongs to the TUB family.
genes like me logo Genes that share domains with TULP2: view

Function for TULP2 Gene

Molecular function for TULP2 Gene

GENATLAS Biochemistry:
tubby-like protein 2,weakly expressed in retina,highly in testis

Phenotypes From GWAS Catalog for TULP2 Gene

Gene Ontology (GO) - Molecular Function for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 20889716
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with TULP2: view
genes like me logo Genes that share phenotypes with TULP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TULP2

CRISPR Products

miRNA for TULP2 Gene

miRTarBase miRNAs that target TULP2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TULP2 Gene

Localization for TULP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TULP2 Gene

Cytoplasm. Secreted. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TULP2 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005929 cilium IBA --
genes like me logo Genes that share ontologies with TULP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TULP2 Gene

Pathways & Interactions for TULP2 Gene

SuperPathways for TULP2 Gene

No Data Available

Interacting Proteins for TULP2 Gene

Gene Ontology (GO) - Biological Process for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 9096357
GO:0097500 receptor localization to non-motile cilium IBA --
GO:1903546 protein localization to photoreceptor outer segment IBA --
genes like me logo Genes that share ontologies with TULP2: view

No data available for Pathways by source and SIGNOR curated interactions for TULP2 Gene

Drugs & Compounds for TULP2 Gene

No Compound Related Data Available

Transcripts for TULP2 Gene

Unigene Clusters for TULP2 Gene

Tubby like protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TULP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: -

Relevant External Links for TULP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TULP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TULP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TULP2 Gene

This gene is overexpressed in Testis (x36.3).

Protein differential expression in normal tissues from HIPED for TULP2 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TULP2 Gene

Protein tissue co-expression partners for TULP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TULP2 Gene:


SOURCE GeneReport for Unigene cluster for TULP2 Gene:


mRNA Expression by UniProt/SwissProt for TULP2 Gene:

Tissue specificity: Strongly expressed in testis. Also expressed in retina. Expressed in cancer cell lines.

Evidence on tissue expression from TISSUES for TULP2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TULP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TULP2 Gene

Orthologs for TULP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TULP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TULP2 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia TULP2 33 34
  • 77.35 (n)
(Bos Taurus)
Mammalia TULP2 33 34
  • 76.05 (n)
(Rattus norvegicus)
Mammalia Tulp2 33
  • 69.81 (n)
(Mus musculus)
Mammalia Tulp2 33 16 34
  • 68.82 (n)
(Monodelphis domestica)
Mammalia TULP2 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
(Anolis carolinensis)
Reptilia TULP2 34
  • 32 (a)
(Danio rerio)
Actinopterygii TULP2 34
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta king-tubby 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea tub-1 35 34
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for TULP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TULP2 Gene

Gene Tree for TULP2 (if available)
Gene Tree for TULP2 (if available)

Paralogs for TULP2 Gene

Paralogs for TULP2 Gene

(3) SIMAP similar genes for TULP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TULP2: view

Variants for TULP2 Gene

Sequence variations from dbSNP and Humsavar for TULP2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000028104 -- 48,897,360(-) C/A coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000113043 -- 48,889,569(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000307076 -- 48,883,724(-) A/G intron_variant
rs1000446799 -- 48,888,349(-) C/T intron_variant
rs1000490397 -- 48,880,428(-) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TULP2 Gene

Variant ID Type Subtype PubMed ID
esv2670526 CNV deletion 23128226
esv3644604 CNV loss 21293372
esv3644605 CNV loss 21293372
esv3644606 CNV loss 21293372
esv3644607 CNV insertion 21293372
nsv470148 CNV gain 18288195
nsv833855 CNV loss 17160897
nsv833856 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for TULP2 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TULP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TULP2 Gene

Disorders for TULP2 Gene

Additional Disease Information for TULP2

No disorders were found for TULP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TULP2 Gene

Publications for TULP2 Gene

  1. Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PMID: 9096357) North MA … Nishina PM (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 58
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  5. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 58

Products for TULP2 Gene

Sources for TULP2 Gene

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