This gene produces a long non-coding RNA that interacts with the Polycomb repressor complex and functions in the epigenetic regulation of transcription. This RNA promotes cell proliferation and is upregulated in tumor cells. It may act as a sponge for microRNAs. The homologous mouse gene is required for differentiation of retina. Alternative splicing results in multiple transcr... See more...

Aliases for TUG1 Gene

Subcategory (RNA class) for TUG1 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for TUG1 Gene

  • Taurine Up-Regulated 1 2 3 5
  • TUG1 2 5 165
  • Taurine Up-Regulated 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 80 2 3
  • NCRNA00080 2 3
  • LINC00080 2 3
  • Taurine Upregulated 1 (Non-Protein Coding) 2
  • Taurine Upregulated Gene 1 3
  • Non-Protein Coding RNA 80 2
  • TUG1 Noncoding RNA 3
  • NONHSAG033691.2 91
  • HSALNG0134930 164
  • FLJ20618 2
  • TI-227H 3

External Ids for TUG1 Gene

Previous GeneCards Identifiers for TUG1 Gene

  • GC22P029692
  • GC22P031365
  • GC22P014327

Summaries for TUG1 Gene

Entrez Gene Summary for TUG1 Gene

  • This gene produces a long non-coding RNA that interacts with the Polycomb repressor complex and functions in the epigenetic regulation of transcription. This RNA promotes cell proliferation and is upregulated in tumor cells. It may act as a sponge for microRNAs. The homologous mouse gene is required for differentiation of retina. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017]

GeneCards Summary for TUG1 Gene

TUG1 (Taurine Up-Regulated 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TUG1 include Hepatoblastoma and Intrahepatic Cholangiocarcinoma.

Gene Wiki entry for TUG1 Gene

Rfam classification for TUG1 Gene

  • Taurine upregulated gene 1 conserved region 4
  • Taurine upregulated gene 1 conserved region 3
  • Taurine upregulated gene 1 conserved region 1
  • Taurine upregulated gene 1 conserved region 2

Additional gene information for TUG1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for TUG1 Gene

Genomics for TUG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TUG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUG1 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the TUG1 gene promoter:
  • CP2
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Olf-1
  • p53
  • Pax-2
  • Pax-2a

Genomic Locations for TUG1 Gene

Genomic Locations for TUG1 Gene
chr22:30,969,158-30,985,225
(GRCh38/hg38)
Size:
16,068 bases
Orientation:
Plus strand
chr22:31,365,634-31,375,381
(GRCh37/hg19)
Size:
9,748 bases
Orientation:
Plus strand

Genomic View for TUG1 Gene

Genes around TUG1 on UCSC Golden Path with GeneCards custom track
TUG1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
TUG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUG1 Gene

Proteins for TUG1 Gene

Post-translational modifications for TUG1 Gene

No Post-translational modifications

Other Protein References for TUG1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TUG1 Gene

Domains & Families for TUG1 Gene

Gene Families for TUG1 Gene

genes like me logo Genes that share domains with TUG1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TUG1 Gene

Function for TUG1 Gene

Phenotypes From GWAS Catalog for TUG1 Gene

genes like me logo Genes that share phenotypes with TUG1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUG1 Gene

Localization for TUG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUG1 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TUG1 Gene

Pathways & Interactions for TUG1 Gene

PathCards logo

SuperPathways for TUG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TUG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042478 regulation of eye photoreceptor cell development IEA --
genes like me logo Genes that share ontologies with TUG1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for TUG1 Gene

Drugs & Compounds for TUG1 Gene

No Compound Related Data Available

Transcripts for TUG1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for TUG1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C98C_9606 lncRNA 7542 3

HGNC: 26066,

RefSeq: NR_002323,

LNCipedia: TUG1:56,

URS000075AC75_9606 lncRNA 7598 2

RefSeq: NR_110492,

LNCipedia: TUG1:57,

URS0000759C95_9606 lncRNA 7528 2

RefSeq: NR_110493,

LNCipedia: TUG1:58,

URS0000CCDFC7_9606 lncRNA 7652 1

RefSeq: NR_152871,

URS0000CCE0A4_9606 lncRNA 7472 1

RefSeq: NR_152870,

TUG1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for TUG1 Gene

16 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUG1 Gene

No ASD Table

Relevant External Links for TUG1 Gene

GeneLoc Exon Structure for
TUG1

Expression for TUG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUG1

SOURCE GeneReport for Unigene cluster for TUG1 Gene:

Hs.554829
genes like me logo Genes that share expression patterns with TUG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUG1 Gene

Orthologs for TUG1 Gene

Evolution for TUG1 Gene

ENSEMBL:
Gene Tree for TUG1 (if available)
TreeFam:
Gene Tree for TUG1 (if available)

No data available for Orthologs for TUG1 Gene

Paralogs for TUG1 Gene

No data available for Paralogs for TUG1 Gene

Variants for TUG1 Gene

Additional dbSNP identifiers (rs#s) for TUG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TUG1 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv9896 CNV gain 18304495

Additional Variant Information for TUG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TUG1 Gene

Disorders for TUG1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for TUG1 Gene - From: LncRNADisease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TUG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUG1

genes like me logo Genes that share disorders with TUG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUG1 Gene

Publications for TUG1 Gene

  1. Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells. (PMID: 28205334) Wang Y … Zhang W (Cancer science 2017) 2 3
  2. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PMID: 24381249) Sauvageau M … Rinn JL (eLife 2013) 2 3
  3. Long intergenic non-coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder. (PMID: 22961206) Han Y … Cai Z (Journal of surgical oncology 2013) 2 3
  4. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao WJ … Zhang ZY (World journal of gastroenterology 2013) 2 3
  5. The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. (PMID: 15797018) Young TL … Cepko CL (Current biology : CB 2005) 2 3

Products for TUG1 Gene

Sources for TUG1 Gene