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This gene produces a long non-coding RNA that interacts with the Polycomb repressor complex and functions in the epigenetic regulation of transcription. This RNA promotes cell proliferation and is upregulated in tumor cells. It may act as a sponge for microRNAs. The homologous mouse gene is required for differentiation of retina. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017]
TUG1 (Taurine Up-Regulated 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TUG1 include Hepatoblastoma and Intrahepatic Cholangiocarcinoma.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0042478 | regulation of eye photoreceptor cell development | IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075C98C_9606 | lncRNA | 7542 | 3 |
HGNC: 26066, RefSeq: NR_002323, LNCipedia: TUG1:56, |
URS000075AC75_9606 | lncRNA | 7598 | 2 |
RefSeq: NR_110492, LNCipedia: TUG1:57, |
URS0000759C95_9606 | lncRNA | 7528 | 2 |
RefSeq: NR_110493, LNCipedia: TUG1:58, |
URS0000CCDFC7_9606 | lncRNA | 7652 | 1 |
RefSeq: NR_152871, |
URS0000CCE0A4_9606 | lncRNA | 7472 | 1 |
RefSeq: NR_152870, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1110864 | OTHER | inversion | 24896259 |
nsv9896 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
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hepatoblastoma |
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intrahepatic cholangiocarcinoma |
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relapsing-remitting multiple sclerosis |
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pulmonary disease, chronic obstructive |
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atherosclerosis susceptibility |
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