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TUG1 Gene(RNA Gene)

Taurine Up-Regulated 1 (Non-Protein Coding)

GCID:
GC22P030969
GIFtS:
25
Genes Participants
UDN Logo

Aliases for TUG1 Gene

Subcategory (RNA class) for TUG1 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for TUG1 Gene

  • Taurine Up-Regulated 1 (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 80 2 3
  • Taurine Upregulated 1 (Non-Protein Coding) 2
  • Taurine Upregulated Gene 1 3
  • Non-Protein Coding RNA 80 2
  • TUG1 Noncoding RNA 3
  • NCRNA00080 3
  • LINC00080 3
  • TI-227H 3

External Ids for TUG1 Gene

Previous GeneCards Identifiers for TUG1 Gene

  • GC22P029692
  • GC22P031365
  • GC22P014327

Summaries for TUG1 Gene

Entrez Gene Summary for TUG1 Gene

  • This gene produces a long non-coding RNA that interacts with the Polycomb repressor complex and functions in the epigenetic regulation of transcription. This RNA promotes cell proliferation and is upregulated in tumor cells. It may act as a sponge for microRNAs. The homologous mouse gene is required for differentiation of retina. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017]

GeneCards Summary for TUG1 Gene

TUG1 (Taurine Up-Regulated 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with TUG1 include Bladder Urothelial Carcinoma.

Gene Wiki entry for TUG1 Gene

Additional gene information for TUG1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUG1 Gene

Genomics for TUG1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TUG1 Gene

Promoters and enhancers for TUG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22I030967 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 576.3 +0.0 31 3.1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF213 TUG1 MORC2 ENSG00000276664 SF3A1 RNF215 PES1 PRR14L DEPDC5 OSBP2
GH22I030234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 64.7 -722.5 -722481 24.6 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF416 ZNF143 FOS ZNF263 SP5 LIF LOC91370 TUG1 SF3A1 EWSR1 MORC2 PES1 RNF215 TBC1D10A ENSG00000272689
GH22I031097 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 44.7 +133.8 133840 10.5 PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF143 FOS DEK SP3 SELENOM TUG1 MORC2 RNF185 SF3A1 PRR14L DEPDC5 PES1 EIF4ENIF1 PATZ1
GH22I031077 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 32.9 +113.7 113686 10.3 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 ENSG00000273387 SMTN TUG1 MORC2 SELENOM SF3A1 INPP5J TBC1D10A PRR14L PES1
GH22I030415 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 32.7 -547.8 -547772 11.6 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 RNF215 ENSG00000272689 ENSG00000273350 MTFP1 RNU6-564P TUG1 SF3A1 TBC1D10A SEC14L3 PES1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TUG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUG1 gene promoter:

Genomic Locations for TUG1 Gene

Genomic Locations for TUG1 Gene
chr22:30,969,211-30,979,395
(GRCh38/hg38)
Size:
10,185 bases
Orientation:
Plus strand
chr22:31,365,634-31,375,381
(GRCh37/hg19)

Genomic View for TUG1 Gene

Genes around TUG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUG1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TUG1 Gene

Proteins for TUG1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for TUG1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TUG1 Gene

Domains & Families for TUG1 Gene

Gene Families for TUG1 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TUG1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TUG1 Gene

Function for TUG1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for TUG1 Gene

Phenotypes for TUG1 Gene

GenomeRNAi human phenotypes for TUG1:
genes like me logo Genes that share phenotypes with TUG1: view

Animal Model Products

miRNA for TUG1 Gene

miRTarBase miRNAs that target TUG1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUG1 Gene

Localization for TUG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUG1 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TUG1 Gene

Pathways & Interactions for TUG1 Gene

SuperPathways for TUG1 Gene

PathCards logo More details on SuperPathways for TUG1
No Data Available

Interacting Proteins for TUG1 Gene

Gene Ontology (GO) - Biological Process for TUG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TUG1 Gene

Drugs & Compounds for TUG1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TUG1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TUG1 Gene

(8) Additional mRNA sequences :
(707) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUG1 Gene

Taurine upregulated 1 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUG1 Gene

No ASD Table

Relevant External Links for TUG1 Gene

GeneLoc Exon Structure for
TUG1
ECgene alternative splicing isoforms for
TUG1

Expression for TUG1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUG1 Gene

mRNA expression in normal human tissues for TUG1 Gene
mRNA expression by BioGPS for TUG1 GenemRNA expression by GTEx for TUG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TUG1 Gene:

TUG1

SOURCE GeneReport for Unigene cluster for TUG1 Gene:

Hs.554829
genes like me logo Genes that share expression patterns with TUG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUG1 Gene

Orthologs for TUG1 Gene

Evolution for TUG1 Gene

ENSEMBL:
Gene Tree for TUG1 (if available)
TreeFam:
Gene Tree for TUG1 (if available)

No data available for Orthologs for TUG1 Gene

Paralogs for TUG1 Gene

No data available for Paralogs for TUG1 Gene

Variants for TUG1 Gene

Sequence variations from dbSNP and Humsavar for TUG1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000116196 -- 30,970,885(+) G/T non_coding_transcript_variant
rs1000284790 -- 30,970,519(+) G/C non_coding_transcript_variant
rs1000333069 -- 30,976,225(+) AAAA/AA non_coding_transcript_variant
rs1000808730 -- 30,975,994(+) C/T non_coding_transcript_variant
rs1001040346 -- 30,967,743(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TUG1 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv9896 CNV gain 18304495

Additional Variant Information for TUG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TUG1 Gene

Disorders for TUG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TUG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUG1

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TUG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUG1 Gene

Publications for TUG1 Gene

  1. Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells. (PMID: 28205334) Wang Y … Zhang W (Cancer science 2017) 2 3 58
  2. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PMID: 24381249) Sauvageau M … Rinn JL (eLife 2013) 2 3 58
  3. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao WJ … Zhang ZY (World journal of gastroenterology 2013) 2 3 58
  4. Long intergenic non-coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder. (PMID: 22961206) Han Y … Cai Z (Journal of surgical oncology 2013) 2 3 58
  5. The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. (PMID: 15797018) Young TL … Cepko CL (Current biology : CB 2005) 2 3 58

Products for TUG1 Gene

Sources for TUG1 Gene

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