Aliases for TUBGCP5 Gene

Aliases for TUBGCP5 Gene

  • Tubulin Gamma Complex Associated Protein 5 2 3 5
  • Gamma-Tubulin Complex Component GCP5 2 3
  • Gamma-Tubulin Complex Component 5 3 4
  • GCP5 3 4
  • Tubulin, Gamma Complex Associated Protein 5 2
  • KIAA1899 4
  • GCP-5 4

External Ids for TUBGCP5 Gene

Previous GeneCards Identifiers for TUBGCP5 Gene

  • GC15P019112
  • GC15M016124
  • GC15P020251
  • GC15P020381
  • GC15P020384
  • GC15P022833
  • GC15P001146

Summaries for TUBGCP5 Gene

GeneCards Summary for TUBGCP5 Gene

TUBGCP5 (Tubulin Gamma Complex Associated Protein 5) is a Protein Coding gene. Diseases associated with TUBGCP5 include Cataract 25 and Chromosome 15Q11.2 Deletion Syndrome. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot Summary for TUBGCP5 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP5 Gene

Additional gene information for TUBGCP5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUBGCP5 Gene

Genomics for TUBGCP5 Gene

GeneHancer (GH) Regulatory Elements for TUBGCP5 Gene

Promoters and enhancers for TUBGCP5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J023038 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.5 +0.3 287 2.4 ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G GTF2E2 PHF8 JUND ZFX TUBGCP5 ENSG00000259414 ENSG00000259098 piR-43105-185 RF00017-1706
GH15J022991 Enhancer 0.4 Ensembl 6 +47.8 47772 1.4 ATF4 PRDM1 CEBPB TUBGCP5 HE856158 CYFIP1 RF00017-1706
GH15J023036 Enhancer 0.6 ENCODE 0.7 +3.5 3540 0.2 CTCF MYC RAD21 TRIM22 SIN3A SMC3 MAX YY1 KLF13 SMARCA5 TUBGCP5 piR-43105-185 RF00017-1706
GH15J022989 Enhancer 0.4 ENCODE 0.3 +49.6 49599 0.4 CTCF ZFHX2 ZNF398 RAD21 EGR2 CYFIP1 HE856158 TUBGCP5 RF00017-1706
GH15J022990 Enhancer 0.3 ENCODE 0.3 +49.9 49920 0.2 CTCF CYFIP1 HE856158 TUBGCP5 RF00017-1706
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUBGCP5

Top Transcription factor binding sites by QIAGEN in the TUBGCP5 gene promoter:
  • C/EBPalpha
  • FOXC1
  • FOXD3
  • Msx-1
  • Nkx2-2
  • POU2F1
  • POU2F1a
  • POU3F2
  • Sox5
  • Sox9

Genomic Locations for TUBGCP5 Gene

Genomic Locations for TUBGCP5 Gene
56,482 bases
Minus strand
40,498 bases
Plus strand

Genomic View for TUBGCP5 Gene

Genes around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP5 Gene

Proteins for TUBGCP5 Gene

  • Protein details for TUBGCP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-tubulin complex component 5
    Protein Accession:
    Secondary Accessions:
    • E9PB12
    • Q6IQ52
    • Q96PY8

    Protein attributes for TUBGCP5 Gene

    1024 amino acids
    Molecular mass:
    118321 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
    • Sequence=AAH46182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK056416; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AK056416; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB67792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP5 Gene


neXtProt entry for TUBGCP5 Gene

Post-translational modifications for TUBGCP5 Gene

  • Ubiquitination at Lys570, Lys590, and Lys663
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBGCP5 Gene

Domains & Families for TUBGCP5 Gene

Gene Families for TUBGCP5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUBGCP5 Gene

  • Spc97/Spc98

Suggested Antigen Peptide Sequences for TUBGCP5 Gene

GenScript: Design optimal peptide antigens:
  • Gamma-tubulin complex component 5 (GCP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TUBGCP family.
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP5: view

Function for TUBGCP5 Gene

Molecular function for TUBGCP5 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Phenotypes From GWAS Catalog for TUBGCP5 Gene

Gene Ontology (GO) - Molecular Function for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IDA 11694571
GO:0043015 gamma-tubulin binding IBA,IEA 21873635
GO:0051011 contributes_to microtubule minus-end binding IBA 21873635
genes like me logo Genes that share ontologies with TUBGCP5: view
genes like me logo Genes that share phenotypes with TUBGCP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBGCP5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP5 Gene

Localization for TUBGCP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBGCP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA 21873635
GO:0000930 gamma-tubulin complex IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA,IBA 21399614
genes like me logo Genes that share ontologies with TUBGCP5: view

Pathways & Interactions for TUBGCP5 Gene

genes like me logo Genes that share pathways with TUBGCP5: view

Pathways by source for TUBGCP5 Gene

3 Qiagen pathways for TUBGCP5 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Hedgehog Signaling in Mammals
  • Parkinson's Disease Pathway

Gene Ontology (GO) - Biological Process for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA 21873635
GO:0007020 microtubule nucleation IEA,IDA 11694571
GO:0031122 cytoplasmic microtubule organization IBA 21873635
GO:0051225 spindle assembly IBA 21873635
GO:0051321 meiotic cell cycle IBA 21873635
genes like me logo Genes that share ontologies with TUBGCP5: view

No data available for SIGNOR curated interactions for TUBGCP5 Gene

Drugs & Compounds for TUBGCP5 Gene

No Compound Related Data Available

Transcripts for TUBGCP5 Gene

mRNA/cDNA for TUBGCP5 Gene

10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBGCP5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP5 Gene

No ASD Table

Relevant External Links for TUBGCP5 Gene

GeneLoc Exon Structure for

Expression for TUBGCP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUBGCP5 Gene

Protein differential expression in normal tissues from HIPED for TUBGCP5 Gene

This gene is overexpressed in Heart (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBGCP5 Gene

Protein tissue co-expression partners for TUBGCP5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUBGCP5

SOURCE GeneReport for Unigene cluster for TUBGCP5 Gene:


mRNA Expression by UniProt/SwissProt for TUBGCP5 Gene:

Tissue specificity: Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.

Evidence on tissue expression from TISSUES for TUBGCP5 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TUBGCP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBGCP5 Gene

Orthologs for TUBGCP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBGCP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TUBGCP5 30
  • 99.45 (n)
(Canis familiaris)
Mammalia TUBGCP5 30
  • 89.78 (n)
(Bos Taurus)
Mammalia TUBGCP5 30
  • 89.55 (n)
(Mus musculus)
Mammalia Tubgcp5 17 30
  • 87.14 (n)
(Rattus norvegicus)
Mammalia Tubgcp5 30
  • 87.04 (n)
(Gallus gallus)
Aves TUBGCP5 30
  • 78.6 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp5 30
  • 71.86 (n)
Str.18945 30
(Danio rerio)
Actinopterygii tubgcp5 30
  • 68.82 (n)
wufa03b04 30
fruit fly
(Drosophila melanogaster)
Insecta Grip128 30
  • 42.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001227 30
  • 41.17 (n)
Species where no ortholog for TUBGCP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP5 Gene

Gene Tree for TUBGCP5 (if available)
Gene Tree for TUBGCP5 (if available)
Evolutionary constrained regions (ECRs) for TUBGCP5: view image

Paralogs for TUBGCP5 Gene

Paralogs for TUBGCP5 Gene

genes like me logo Genes that share paralogs with TUBGCP5: view

Variants for TUBGCP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUBGCP5 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
709938 Benign: not provided 23,010,031(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
710289 Benign: not provided 23,005,480(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
717098 Likely Benign: not provided 23,003,072(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
717714 Likely Benign: not provided 23,039,414(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
726102 Benign: not provided 23,026,108(-) T/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TUBGCP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP5 Gene

Variant ID Type Subtype PubMed ID
dgv2403n100 CNV gain 25217958
dgv2404n100 CNV gain 25217958
dgv2405n100 CNV gain+loss 25217958
dgv2406n100 CNV gain 25217958
dgv2407n100 CNV gain+loss 25217958
dgv2408n100 CNV loss 25217958
dgv2409n100 CNV loss 25217958
dgv287n27 CNV gain 19166990
dgv4317n54 CNV loss 21841781
dgv4318n54 CNV gain 21841781
dgv4319n54 CNV gain+loss 21841781
dgv4320n54 CNV gain 21841781
dgv4322n54 CNV loss 21841781
dgv708e212 CNV loss 25503493
dgv709e212 CNV gain 25503493
dgv8n31 CNV loss 19718026
esv2474417 CNV loss 19546169
esv34463 CNV gain 17911159
esv3569265 CNV gain 25503493
esv3635806 CNV loss 21293372
esv3635807 CNV gain 21293372
esv3635815 CNV loss 21293372
esv3635816 CNV gain 21293372
esv3635817 CNV loss 21293372
esv3635818 CNV gain 21293372
esv3892604 CNV gain+loss 25118596
esv3892622 CNV gain 25118596
esv3892626 CNV gain+loss 25118596
nsv1036020 CNV loss 25217958
nsv1040546 CNV gain 25217958
nsv1113689 CNV deletion 24896259
nsv1459 CNV insertion 18451855
nsv433290 CNV loss 18776910
nsv433429 CNV gain 18776910
nsv442359 CNV gain+loss 18776908
nsv456612 CNV loss 19166990
nsv456635 CNV loss 19166990
nsv471225 CNV gain 18288195
nsv471226 CNV loss 18288195
nsv471375 CNV loss 19718026
nsv511042 OTHER inversion 20534489
nsv568225 CNV loss 21841781
nsv568226 CNV gain 21841781
nsv568235 CNV loss 21841781
nsv568258 CNV loss 21841781
nsv568259 CNV loss 21841781
nsv9183 CNV gain+loss 18304495

Variation tolerance for TUBGCP5 Gene

Residual Variation Intolerance Score: 6.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBGCP5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Disorders for TUBGCP5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TUBGCP5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cataract 25
  • ctrct25
chromosome 15q11.2 deletion syndrome
  • duplication 15q11-q13 syndrome
prader-willi syndrome
  • pws
albinism, oculocutaneous, type ii
  • oca2
retinitis pigmentosa 22
  • rp22
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TUBGCP5

genes like me logo Genes that share disorders with TUBGCP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBGCP5 Gene

Publications for TUBGCP5 Gene

  1. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy SM … Stearns T (Molecular biology of the cell 2001) 2 3 4 54
  2. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. (PMID: 18316369) Izumi N … Kikuchi A (The Journal of biological chemistry 2008) 3 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. (PMID: 14508708) Chai JH … Nicholls RD (American journal of human genetics 2003) 3 4 54

Products for TUBGCP5 Gene

Sources for TUBGCP5 Gene