TUBG2 Gene (Protein Coding)

Tubulin Gamma 2

GC17P042659
GIFtS:
37
See more...

Aliases for TUBG2 Gene

Aliases for TUBG2 Gene

  • Tubulin Gamma 2 2 3 5
  • Tubulin Gamma-2 Chain 3 4
  • Gamma-2-Tubulin 3 4
  • Tubulin Gamma 2 Chain 3
  • Tubulin, Gamma 2 2
  • TUBG2 5

External Ids for TUBG2 Gene

Previous GeneCards Identifiers for TUBG2 Gene

  • GC17M040390
  • GC17P042975
  • GC17P040720
  • GC17P041184
  • GC17P041144
  • GC17P038064
  • GC17P040811
  • GC17P036576

Summaries for TUBG2 Gene

GeneCards Summary for TUBG2 Gene

TUBG2 (Tubulin Gamma 2) is a Protein Coding gene. Diseases associated with TUBG2 include Childhood Pilocytic Astrocytoma. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot Summary for TUBG2 Gene

  • Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Tocris Summary for TUBG2 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBG2 Gene

Additional gene information for TUBG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUBG2 Gene

Genomics for TUBG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TUBG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUBG2

Top Transcription factor binding sites by QIAGEN in the TUBG2 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for TUBG2 Gene

Latest Assembly
chr17:42,659,284-42,667,006
(GRCh38/hg38)
Size:
7,723 bases
Orientation:
Plus strand

Previous Assembly
chr17:40,811,302-40,819,024
(GRCh37/hg19 by Entrez Gene)
Size:
7,723 bases
Orientation:
Plus strand

chr17:40,811,323-40,819,024
(GRCh37/hg19 by Ensembl)
Size:
7,702 bases
Orientation:
Plus strand

Genomic View for TUBG2 Gene

Genes around TUBG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBG2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TUBG2 Gene

Proteins for TUBG2 Gene

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  3. Assay products for research

  • Protein details for TUBG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH3-TBG2_HUMAN
    Recommended name:
    Tubulin gamma-2 chain
    Protein Accession:
    Q9NRH3
    Secondary Accessions:
    • A6NDI4
    • Q32NB2

    Protein attributes for TUBG2 Gene

    Size:
    451 amino acids
    Molecular mass:
    51092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBG2 Gene

Protein Expression for TUBG2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TUBG2 Gene

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBG2 Gene

Domains & Families for TUBG2 Gene

Gene Families for TUBG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUBG2 Gene

InterPro:
Blocks:
  • Gamma tubulin signature

Suggested Antigen Peptide Sequences for TUBG2 Gene

GenScript: Design optimal peptide antigens:
  • Gamma-2-tubulin (TBG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRH3

UniProtKB/Swiss-Prot:

TBG2_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBG2: view

Function for TUBG2 Gene

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  3. miRNA products for research
  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for TUBG2 Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Phenotypes From GWAS Catalog for TUBG2 Gene

Gene Ontology (GO) - Molecular Function for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 10903841
GO:0005200 structural constituent of cytoskeleton IBA 21873635
GO:0005525 GTP binding IBA 21873635
genes like me logo Genes that share ontologies with TUBG2: view
genes like me logo Genes that share phenotypes with TUBG2: view

Animal Models for TUBG2 Gene

MGI Knock Outs for TUBG2:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBG2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TUBG2 Gene

Localization for TUBG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBG2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBG2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
mitochondrion 1
golgi apparatus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000930 gamma-tubulin complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IEA,IBA 21873635
genes like me logo Genes that share ontologies with TUBG2: view

Pathways & Interactions for TUBG2 Gene

PathCards logo

SuperPathways for TUBG2 Gene

genes like me logo Genes that share pathways with TUBG2: view

Pathways by source for TUBG2 Gene

1 KEGG pathway for TUBG2 Gene
1 GeneGo (Thomson Reuters) pathway for TUBG2 Gene
  • Cytoskeleton remodeling Neurofilaments
9 Qiagen pathways for TUBG2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Epithelial Adherens Junctions
  • Epithelial Tight Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Hedgehog Signaling in Mammals

Gene Ontology (GO) - Biological Process for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA 21873635
GO:0000212 meiotic spindle organization IBA 21873635
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0007017 microtubule-based process IEA --
genes like me logo Genes that share ontologies with TUBG2: view

No data available for SIGNOR curated interactions for TUBG2 Gene

Drugs & Compounds for TUBG2 Gene

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  1. Drug products for research

(3) Drugs for TUBG2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
MPC 6827 hydrochloride Pharma Potent microtubule inhibitor, Inhibitor of microtubule polymerization; antimitotic and antitumor 0
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBG2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Noscapine hydrochloride
912-60-7
taxol
33069-62-4

(5) Tocris Compounds for TUBG2 Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBG2: view

Transcripts for TUBG2 Gene

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mRNA/cDNA for TUBG2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBG2

Alternative Splicing Database (ASD) splice patterns (SP) for TUBG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7: -

Relevant External Links for TUBG2 Gene

GeneLoc Exon Structure for
TUBG2

Expression for TUBG2 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUBG2 Gene

mRNA expression in normal human tissues for TUBG2 Gene
mRNA expression by GTEx for TUBG2 GenemRNA expression by BioGPS for TUBG2 Gene

Protein differential expression in normal tissues from HIPED for TUBG2 Gene

This gene is overexpressed in Heart (56.1) and Ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBG2 Gene



Protein tissue co-expression partners for TUBG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUBG2

SOURCE GeneReport for Unigene cluster for TUBG2 Gene:

Hs.708059

Evidence on tissue expression from TISSUES for TUBG2 Gene

  • Nervous system(4.9)
  • Lung(4.5)
genes like me logo Genes that share expression patterns with TUBG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBG2 Gene

Orthologs for TUBG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TUBG2 29 30
  • 99.63 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TUBG1 30
  • 98 (a)
 OneToOne
TUBG2 29
  • 93.35 (n)
Cow
(Bos Taurus)
 Mammalia TUBG2 29 30
  • 93.35 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tubg2 29 16 30
  • 92.02 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tubg2 29
  • 91.5 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia TUBG2 30
  • 82 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 23 (a)
 ManyToMany
Chicken
(Gallus gallus)
 Aves -- 30
  • 96 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia TUBG2 30
  • 93 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii tubg1 30
  • 96 (a)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12613 29
Fruit Fly
(Drosophila melanogaster)
 Insecta gammaTub37C 30 31
  • 76 (a)
 ManyToMany
gammaTub23C 29 30 31
  • 71.2 (n)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007834 29
  • 72.57 (n)
Worm
(Caenorhabditis elegans)
 Secernentea tbg-1 31
  • 43 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TUB4 30
  • 38 (a)
 OneToMany
Barley
(Hordeum vulgare)
 Liliopsida Hv.90 29
Rice
(Oryza sativa)
 Liliopsida Os.2349 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 82 (a)
 OneToMany
Species where no ortholog for TUBG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TUBG2 Gene

ENSEMBL:
Gene Tree for TUBG2 (if available)
TreeFam:
Gene Tree for TUBG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUBG2: view image
Alliance of Genome Resources:
Additional Orthologs for TUBG2

Paralogs for TUBG2 Gene

Variants for TUBG2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUBG2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs525911 Benign: not provided 42,659,901(+) A/G
NM_016437.3(TUBG2):c.117A>G (p.Glu39=) 		SYNONYMOUS
rs1046097 -- p.Met413Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TUBG2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TUBG2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897
nsv953899 CNV deletion 24416366

Variation tolerance for TUBG2 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.58; 95.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBG2
Leiden Open Variation Database (LOVD)
TUBG2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBG2 Gene

Disorders for TUBG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUBG2 Gene - From: COP

Disorder Aliases PubMed IDs
childhood pilocytic astrocytoma
  • pediatric pilocytic astrocytoma
- elite association - COSMIC cancer census association via MalaCards
Search TUBG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUBG2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TUBG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBG2 Gene

Publications for TUBG2 Gene

  1. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 40
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The gamma-tubulin gene family in humans. (PMID: 10903841) Wise DO … Oakley BR (Genomics 2000) 3 4
  5. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3

ExternalLinks

View latest publications for TUBG2 gene in Mastermind

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Sources for TUBG2 Gene