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Aliases for TUBG2 Gene

Aliases for TUBG2 Gene

  • Tubulin Gamma 2 2 3 5
  • Gamma-2-Tubulin 3 4
  • Tubulin Gamma 2 Chain 3
  • Tubulin Gamma-2 Chain 3
  • Tubulin, Gamma 2 2

External Ids for TUBG2 Gene

Previous GeneCards Identifiers for TUBG2 Gene

  • GC17M040390
  • GC17P042975
  • GC17P040720
  • GC17P041184
  • GC17P041144
  • GC17P038064
  • GC17P040811
  • GC17P036576

Summaries for TUBG2 Gene

GeneCards Summary for TUBG2 Gene

TUBG2 (Tubulin Gamma 2) is a Protein Coding gene. Among its related pathways are PAK Pathway and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot for TUBG2 Gene

  • Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Tocris Summary for TUBG2 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBG2 Gene

Additional gene information for TUBG2 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBG2 Gene

Genomics for TUBG2 Gene

GeneHancer (GH) Regulatory Elements for TUBG2 Gene

Promoters and enhancers for TUBG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042658 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 572.8 +0.2 184 1.5 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 TUBG2 PIR45597
GH17I042660 Enhancer 1.1 ENCODE dbSUPER 570.6 +1.8 1772 1.5 HDAC1 PKNOX1 ARNT ZNF2 ZEB1 ZNF366 RCOR1 FOS ATF7 SMARCC1 TUBG2 MLX RETREG3 TUBG1 PIR45597
GH17I042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 42.9 +19.5 19450 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 TUBG2 HSD17B1P1 ENSG00000267002 HMGN1P29 HMGN2P15 ENSG00000259623
GH17I042565 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 36.3 -91.8 -91810 3.4 HDGF SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MLX CNTNAP1 TUBG2 CAVIN1 FKBP10 ENSG00000259623 VAT1 ENSG00000267765 RPL27 HSD17B1P1
GH17I042576 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32 -81.1 -81064 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC17P042577 GC17P042580 PSMC3IP DHX8 HMGN1P29 ENSG00000267758 TUBG2 NBR2 MLX STAT5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TUBG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBG2 gene promoter:

Genomic Locations for TUBG2 Gene

Genomic Locations for TUBG2 Gene
chr17:42,659,248-42,667,006
(GRCh38/hg38)
Size:
7,759 bases
Orientation:
Plus strand
chr17:40,811,266-40,819,024
(GRCh37/hg19)

Genomic View for TUBG2 Gene

Genes around TUBG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBG2 Gene

Proteins for TUBG2 Gene

  • Protein details for TUBG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH3-TBG2_HUMAN
    Recommended name:
    Tubulin gamma-2 chain
    Protein Accession:
    Q9NRH3
    Secondary Accessions:
    • A6NDI4
    • Q32NB2

    Protein attributes for TUBG2 Gene

    Size:
    451 amino acids
    Molecular mass:
    51092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBG2 Gene

Post-translational modifications for TUBG2 Gene

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBG2 Gene

No data available for DME Specific Peptides for TUBG2 Gene

Domains & Families for TUBG2 Gene

Gene Families for TUBG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TUBG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRH3

UniProtKB/Swiss-Prot:

TBG2_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBG2: view

Function for TUBG2 Gene

Molecular function for TUBG2 Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Phenotypes From GWAS Catalog for TUBG2 Gene

Gene Ontology (GO) - Molecular Function for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 10903841
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBG2: view
genes like me logo Genes that share phenotypes with TUBG2: view

Animal Models for TUBG2 Gene

MGI Knock Outs for TUBG2:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TUBG2 Gene

Localization for TUBG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBG2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBG2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000930 gamma-tubulin complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with TUBG2: view

Pathways & Interactions for TUBG2 Gene

genes like me logo Genes that share pathways with TUBG2: view

Gene Ontology (GO) - Biological Process for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
GO:0007020 microtubule nucleation IEA --
GO:0031122 cytoplasmic microtubule organization IEA --
genes like me logo Genes that share ontologies with TUBG2: view

No data available for SIGNOR curated interactions for TUBG2 Gene

Drugs & Compounds for TUBG2 Gene

(3) Drugs for TUBG2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBG2 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TUBG2 Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBG2: view

Transcripts for TUBG2 Gene

Unigene Clusters for TUBG2 Gene

Tubulin, gamma 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7: -

Relevant External Links for TUBG2 Gene

GeneLoc Exon Structure for
TUBG2
ECgene alternative splicing isoforms for
TUBG2

Expression for TUBG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBG2 Gene

Protein differential expression in normal tissues from HIPED for TUBG2 Gene

This gene is overexpressed in Heart (56.1) and Ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBG2 Gene



Protein tissue co-expression partners for TUBG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBG2 Gene:

TUBG2

SOURCE GeneReport for Unigene cluster for TUBG2 Gene:

Hs.708059

Evidence on tissue expression from TISSUES for TUBG2 Gene

  • Nervous system(4.9)
  • Lung(4.5)
genes like me logo Genes that share expression patterns with TUBG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBG2 Gene

Orthologs for TUBG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBG2 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia TUBG1 34
  • 98 (a)
OneToOne
TUBG2 33
  • 93.35 (n)
cow
(Bos Taurus)
Mammalia TUBG2 33 34
  • 93.35 (n)
mouse
(Mus musculus)
Mammalia Tubg2 33 16 34
  • 92.02 (n)
rat
(Rattus norvegicus)
Mammalia Tubg2 33
  • 91.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TUBG2 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TUBG2 34
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tubg1 34
  • 96 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12613 33
fruit fly
(Drosophila melanogaster)
Insecta gammaTub37C 35 34
  • 77 (a)
gammaTub23C 35 33 34
  • 71.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007834 33
  • 72.57 (n)
worm
(Caenorhabditis elegans)
Secernentea tbg-1 35
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 34
  • 38 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.90 33
rice
(Oryza sativa)
Liliopsida Os.2349 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 82 (a)
OneToMany
Species where no ortholog for TUBG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TUBG2 Gene

ENSEMBL:
Gene Tree for TUBG2 (if available)
TreeFam:
Gene Tree for TUBG2 (if available)

Paralogs for TUBG2 Gene

Paralogs for TUBG2 Gene

genes like me logo Genes that share paralogs with TUBG2: view

Variants for TUBG2 Gene

Sequence variations from dbSNP and Humsavar for TUBG2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000803601 -- 42,662,068(+) G/T intron_variant
rs1000824486 -- 42,663,078(+) A/G intron_variant
rs1000881476 -- 42,666,975(+) T/C 3_prime_UTR_variant
rs1000981577 -- 42,661,142(+) A/G 5_prime_UTR_variant, intron_variant
rs1001424476 -- 42,664,608(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBG2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897
nsv953899 CNV deletion 24416366

Variation tolerance for TUBG2 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.58; 95.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBG2 Gene

Disorders for TUBG2 Gene

Additional Disease Information for TUBG2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TUBG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBG2 Gene

Publications for TUBG2 Gene

  1. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The gamma-tubulin gene family in humans. (PMID: 10903841) Wise DO … Oakley BR (Genomics 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TUBG2 Gene

Sources for TUBG2 Gene

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