Free for academic non-profit institutions. Other users need a Commercial license
TUBG2 (Tubulin Gamma 2) is a Protein Coding gene. Diseases associated with TUBG2 include Childhood Pilocytic Astrocytoma. Among its related pathways are G-Beta Gamma Signaling and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBG1.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA | -- |
GO:0005198 | structural molecule activity | TAS | 10903841 |
GO:0005200 | structural constituent of cytoskeleton | IBA | 21873635 |
GO:0005525 | GTP binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000242 | pericentriolar material | IEA | -- |
GO:0000930 | gamma-tubulin complex | IBA | 21873635 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005813 | centrosome | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
2 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
3 | Cell Cycle, Mitotic |
.83
|
|
4 | PI3K-Akt signaling pathway | ||
5 | Nanog in Mammalian ESC Pluripotency |
14-3-3 Induced Intracellular Signaling
.59
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000070 | mitotic sister chromatid segregation | IBA | 21873635 |
GO:0000212 | meiotic spindle organization | IBA | 21873635 |
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0000278 | mitotic cell cycle | IBA | 21873635 |
GO:0007017 | microtubule-based process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Nocodazole | Experimental | Pharma | Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor | 0 | ||
MPC 6827 hydrochloride | Pharma | Potent microtubule inhibitor, Inhibitor of microtubule polymerization; antimitotic and antitumor | 0 | |||
Vinblastine sulfate | Pharma | Anti-mitotic agent, Disrupts microtubules | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Noscapine hydrochloride |
|
912-60-7 |
|
|
||
taxol |
|
Agonist | 33069-62-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
MPC 6827 hydrochloride | Inhibitor of microtubule polymerization; antimitotic and antitumor | 917369-31-4 |
Nocodazole | Microtubule inhibitor | 31430-18-9 |
Noscapine hydrochloride | Tubulin inhibitor; induces apoptosis | 912-60-7 |
Taxol | Promotes assembly and inhibits disassembly of microtubules | 33069-62-4 |
Vinblastine sulfate | Disrupts microtubules | 143-67-9 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||
SP7: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TUBG2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TUBG1 31 |
|
OneToOne | |
TUBG2 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | TUBG2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tubg2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tubg2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TUBG2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | TUBG2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | tubg1 31 |
|
OneToMany | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12613 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | gammaTub37C 31 32 |
|
ManyToMany | |
gammaTub23C 30 31 32 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007834 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | tbg-1 32 |
|
|
|
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TUB4 31 |
|
OneToMany | |
Barley (Hordeum vulgare) |
Liliopsida | Hv.90 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.2349 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
childhood pilocytic astrocytoma |
|
|