Aliases for TUBG2 Gene
Aliases for TUBG2 Gene
External Ids for TUBG2 Gene
- HGNC: 12419
- Entrez Gene: 27175
- Ensembl: ENSG00000037042
- OMIM: 605785
- UniProtKB: Q9NRH3
Previous GeneCards Identifiers for TUBG2 Gene
- GC17M040390
- GC17P042975
- GC17P040720
- GC17P041184
- GC17P041144
- GC17P038064
- GC17P040811
- GC17P036576
Summaries for TUBG2 Gene
GeneCards Summary for TUBG2 Gene
TUBG2 (Tubulin Gamma 2) is a Protein Coding gene. Among its related pathways are PAK Pathway and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBG1.
UniProtKB/Swiss-Prot for TUBG2 Gene
-
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).
-
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).
No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBG2 Gene
Genomics for TUBG2 Gene
GeneHancer (GH) Regulatory Elements for TUBG2 Gene
Promoters and enhancers for TUBG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TUBG2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TUBG2 Gene
Genomic Locations for TUBG2 Gene
- chr17:42,659,248-42,667,006
- (GRCh38/hg38)
- Size:
- 7,759 bases
- Orientation:
- Plus strand
- chr17:40,811,266-40,819,024
- (GRCh37/hg19)
Genomic View for TUBG2 Gene
Genes around TUBG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by Ensembl
- 17q21.2 by Entrez Gene
- 17q21.2 by HGNC
TUBG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TUBG2 Gene
Proteins for TUBG2 Gene
-
Protein details for TUBG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRH3-TBG2_HUMAN
- Recommended name:
- Tubulin gamma-2 chain
- Protein Accession:
- Q9NRH3
- A6NDI4
- Q32NB2
Protein attributes for TUBG2 Gene
- Size:
- 451 amino acids
- Molecular mass:
- 51092 Da
- Quaternary structure:
- No Data Available
Protein Expression for TUBG2 Gene
Post-translational modifications for TUBG2 Gene
- Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TUBG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TUBG2
- Novus Biologicals Antibodies for TUBG2
- Invitrogen Antibodies for TUBG2
- Search GeneTex for Antibodies for TUBG2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TUBG2
Protein Products
-
OriGene Purified Proteins for TUBG2
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Assay Products
No data available for DME Specific Peptides for TUBG2 Gene
Domains & Families for TUBG2 Gene
Gene Families for TUBG2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TUBG2 Gene
Suggested Antigen Peptide Sequences for TUBG2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NRH3- Family:
-
- Belongs to the tubulin family.
Function for TUBG2 Gene
Molecular function for TUBG2 Gene
- UniProtKB/Swiss-Prot Function:
- Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).
Phenotypes From GWAS Catalog for TUBG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005198 | structural molecule activity | TAS | 10903841 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for TUBG2 Gene
- MGI mutant phenotypes for TUBG2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TUBG2:
Animal Models for TUBG2 Gene
- MGI Knock Outs for TUBG2:
-
- Tubg2 tm1Sts
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TUBG2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TUBG2 gene
-
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- Search ViGene Biosciences for TUBG2
CRISPR Products
-
OriGene CRISPR knockouts for TUBG2
- genomics-online: gRNA clones - Search results for 112 available TUBG2 gene related products
- Overview of 112 available TUBG2 gene related products
- Applied Biological Materials CRISPR for TUBG2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TUBG2
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- Overview of 112 available TUBG2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TUBG2 gene
Clone Products
- Sino Biological Human cDNA Clone for TUBG2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TUBG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TUBG2
-
ViGene Biosciences adenoviral particle packaged cDNA for TUBG2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TUBG2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TUBG2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TUBG2 Gene
Localization for TUBG2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TUBG2 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
- Microtubule organizing center (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000242 | pericentriolar material | IEA | -- |
| GO:0000930 | gamma-tubulin complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IEA | -- |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for TUBG2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Sertoli-Sertoli Cell Junction Dynamics | ||
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | PI3K-Akt signaling pathway | ||
| 5 | Nanog in Mammalian ESC Pluripotency | ||
Pathways by source for TUBG2 Gene
7 Reactome pathways for TUBG2 Gene
1 KEGG pathway for TUBG2 Gene
1 GeneGo (Thomson Reuters) pathway for TUBG2 Gene
Interacting Proteins for TUBG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007017 | microtubule-based process | IEA | -- |
| GO:0007020 | microtubule nucleation | IEA | -- |
| GO:0031122 | cytoplasmic microtubule organization | IEA | -- |
No data available for SIGNOR curated interactions for TUBG2 Gene
Drugs & Compounds for TUBG2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vinblastine sulfate | Pharma | Anti-mitotic agent, Disrupts microtubules | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for TUBG2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| MPC 6827 hydrochloride | Inhibitor of microtubule polymerization; antimitotic and antitumor | 917369-31-4 |
| Nocodazole | Microtubule inhibitor | 31430-18-9 |
| Noscapine hydrochloride | Tubulin inhibitor; induces apoptosis | 912-60-7 |
| Taxol | Promotes assembly and inhibits disassembly of microtubules | 33069-62-4 |
| Vinblastine sulfate | Disrupts microtubules | 143-67-9 |
Transcripts for TUBG2 Gene
mRNA/cDNA for TUBG2 Gene
- (8) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (691) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TUBG2
- genomics-online: gRNA clones - Search results for 112 available TUBG2 gene related products
- Overview of 112 available TUBG2 gene related products
- Applied Biological Materials CRISPR for TUBG2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TUBG2
- GenScript: Design CRISPR guide RNA sequences for TUBG2
miRNA Products
- Search ViGene Biosciences for TUBG2
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for TUBG2
- Browse OriGene Inhibitory RNA Products For TUBG2
- genomics-online: shRNA clones - Search results for 112 available TUBG2 gene related products
- Overview of 112 available TUBG2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TUBG2 gene
Clone Products
- Sino Biological Human cDNA Clone for TUBG2
- VectorBuilder custom plasmid, inducible vectors for TUBG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TUBG2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TUBG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | - |
Expression for TUBG2 Gene
This gene is overexpressed in Heart (56.1) and Ovary (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBG2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TUBG2 Gene:
TUBG2SOURCE GeneReport for Unigene cluster for TUBG2 Gene:
Hs.708059Evidence on tissue expression from TISSUES for TUBG2 Gene
- Nervous system(4.9)
- Lung(4.5)
Primer Products
-
OriGene qPCR primer pairs for TUBG2
-
OriGene qPCR primer pairs and template standards for TUBG2
- genomics-online: primer clones - Search results for 112 available TUBG2 gene related products
- Overview of 112 available TUBG2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBG2 Gene
Orthologs for TUBG2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TUBG2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TUBG1 34 |
|
OneToOne | |
| TUBG2 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | TUBG2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tubg2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tubg2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TUBG2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | TUBG2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | tubg1 34 |
|
OneToMany | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12613 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | gammaTub37C 35 34 |
|
||
| gammaTub23C 35 33 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007834 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | tbg-1 35 |
|
|
|
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TUB4 34 |
|
OneToMany | |
| barley (Hordeum vulgare) |
Liliopsida | Hv.90 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.2349 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for TUBG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TUBG2 Gene
(25) SIMAP similar genes for TUBG2 Gene using alignment to 1 proteins:
Variants for TUBG2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000803601 | -- | 42,662,068(+) | G/T | intron_variant | |
| rs1000824486 | -- | 42,663,078(+) | A/G | intron_variant | |
| rs1000881476 | -- | 42,666,975(+) | T/C | 3_prime_UTR_variant | |
| rs1000981577 | -- | 42,661,142(+) | A/G | 5_prime_UTR_variant, intron_variant | |
| rs1001424476 | -- | 42,664,608(+) | A/G | intron_variant |
Residual Variation Intolerance Score:
14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.58;
95.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TUBG2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TUBG2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBG2 Gene
Disorders for TUBG2 Gene
Additional Disease Information for TUBG2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TUBG2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBG2 Gene
Publications for TUBG2 Gene
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The gamma-tubulin gene family in humans. (PMID: 10903841) Wise DO … Oakley BR (Genomics 2000) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for TUBG2 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 11 available TUBG2 Antibodies ranked by validation data
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- antibodies-online: Search results for available TUBG2 related products ranked by validation data
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- genomics-online: cdna clones - Search results for 112 available TUBG2 gene related products
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Sources for TUBG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
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