Aliases for TUBE1 Gene
Aliases for TUBE1 Gene
External Ids for TUBE1 Gene
- HGNC: 20775
- Entrez Gene: 51175
- Ensembl: ENSG00000074935
- OMIM: 607345
- UniProtKB: Q9UJT0
Previous GeneCards Identifiers for TUBE1 Gene
- GC06M112414
- GC06M112437
- GC06M112498
- GC06M109966
- GC06M112391
Summaries for TUBE1 Gene
-
This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
GeneCards Summary for TUBE1 Gene
TUBE1 (Tubulin Epsilon 1) is a Protein Coding gene. Diseases associated with TUBE1 include Chronic Frontal Sinusitis and Frontal Sinusitis. Among its related pathways are PAK Pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB8.
-
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).
No data available for CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBE1 Gene
Genomics for TUBE1 Gene
GeneHancer (GH) Regulatory Elements for TUBE1 Gene
Promoters and enhancers for TUBE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TUBE1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TUBE1 gene promoter:
Regulatory Element Products
Genomic Locations for TUBE1 Gene
Genomic Locations for TUBE1 Gene
- chr6:112,070,657-112,087,548
- (GRCh38/hg38)
- Size:
- 16,892 bases
- Orientation:
- Minus strand
- chr6:112,391,860-112,408,751
- (GRCh37/hg19)
Genomic View for TUBE1 Gene
Genes around TUBE1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by Ensembl
- 6q21 by Entrez Gene
- 6q21 by HGNC
TUBE1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TUBE1 Gene
Proteins for TUBE1 Gene
-
Protein details for TUBE1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJT0-TBE_HUMAN
- Recommended name:
- Tubulin epsilon chain
- Protein Accession:
- Q9UJT0
- Q5H8W8
- Q8NEG3
Protein attributes for TUBE1 Gene
- Size:
- 475 amino acids
- Molecular mass:
- 52932 Da
- Quaternary structure:
- No Data Available
Protein Expression for TUBE1 Gene
Post-translational modifications for TUBE1 Gene
No Post-translational modifications
Other Protein References for TUBE1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for TUBE1
-
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-
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Protein Products
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-
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-
Abcam proteins for TUBE1
Assay Products
No data available for DME Specific Peptides for TUBE1 Gene
Domains & Families for TUBE1 Gene
Gene Families for TUBE1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for TUBE1 Gene
Suggested Antigen Peptide Sequences for TUBE1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UJT0- Family:
-
- Belongs to the tubulin family.
Function for TUBE1 Gene
Phenotypes From GWAS Catalog for TUBE1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 10620804 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for TUBE1 Gene
- GenomeRNAi human phenotypes for TUBE1:
Animal Model Products
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Vectors and viruses for KO, Activation, Repression, and more
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miRNA for TUBE1 Gene
- miRTarBase miRNAs that target TUBE1
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TUBE1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBE1 Gene
Localization for TUBE1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TUBE1 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with pericentriolar material.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000242 | pericentriolar material | TAS | 10620804 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TUBE1 Gene
Pathways & Interactions for TUBE1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sertoli-Sertoli Cell Junction Dynamics | ||
| 2 | Nanog in Mammalian ESC Pluripotency | ||
| 3 | PAK Pathway | ||
| 4 | G-Beta Gamma Signaling | ||
| 5 | ERK Signaling | ||
Pathways by source for TUBE1 Gene
Interacting Proteins for TUBE1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007017 | microtubule-based process | IEA | -- |
| GO:0007098 | centrosome cycle | TAS | 10620804 |
No data available for SIGNOR curated interactions for TUBE1 Gene
Drugs & Compounds for TUBE1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for TUBE1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| MPC 6827 hydrochloride | Inhibitor of microtubule polymerization; antimitotic and antitumor | 917369-31-4 |
| Nocodazole | Microtubule inhibitor | 31430-18-9 |
| Noscapine hydrochloride | Tubulin inhibitor; induces apoptosis | 912-60-7 |
| Taxol | Promotes assembly and inhibits disassembly of microtubules | 33069-62-4 |
| Vinblastine sulfate | Disrupts microtubules | 143-67-9 |
Transcripts for TUBE1 Gene
mRNA/cDNA for TUBE1 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (147) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TUBE1
- genomics-online: gRNA clones - Search results for 115 available TUBE1 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TUBE1
- GenScript: Design CRISPR guide RNA sequences for TUBE1
miRNA Products
- Search ViGene Biosciences for TUBE1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TUBE1
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- genomics-online: shRNA clones - Search results for 115 available TUBE1 gene related products
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-
ViGene Biosciences ready-to-package AAV shRNAs for TUBE1 gene
Clone Products
- Sino Biological Human cDNA Clone for TUBE1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TUBE1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TUBE1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TUBE1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for TUBE1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
This gene is overexpressed in Monocytes (48.2), Testis (10.9), and Tlymphocyte (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBE1 Gene
NURSA nuclear receptor signaling pathways regulating expression of TUBE1 Gene:
TUBE1SOURCE GeneReport for Unigene cluster for TUBE1 Gene:
Hs.34851Evidence on tissue expression from TISSUES for TUBE1 Gene
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for TUBE1
-
OriGene qPCR primer pairs and template standards for TUBE1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBE1 Gene
Orthologs for TUBE1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TUBE1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TUBE1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tube1 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TUBE1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TUBE1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tube1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TUBE1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TUBE1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TUBE1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tube1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tube1 33 34 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32396 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | tbb-6 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for TUBE1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TUBE1 Gene
Paralogs for TUBE1 Gene
(27) SIMAP similar genes for TUBE1 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for TUBE1 Gene
Variants for TUBE1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000085628 | -- | 112,089,430(-) | T/G | upstream_transcript_variant | |
| rs1000431472 | -- | 112,082,923(-) | G/A | intron_variant | |
| rs1000802493 | -- | 112,075,710(-) | T/C | intron_variant | |
| rs1000919012 | -- | 112,083,320(-) | A/T | intron_variant | |
| rs1000968420 | -- | 112,075,214(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv950495 | CNV | duplication | 24416366 |
| esv3366325 | CNV | insertion | 20981092 |
Residual Variation Intolerance Score:
39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.94;
49.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TUBE1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TUBE1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBE1 Gene
Disorders for TUBE1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic frontal sinusitis |
|
|
| frontal sinusitis |
|
|
| laryngeal tuberculosis |
|
|
Search TUBE1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TUBE1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TUBE1 Gene
Publications for TUBE1 Gene
- Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P … Stearns T (Nature cell biology 2000) 2 3 4 22 58
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Epsilon-tubulin is required for centriole duplication and microtubule organization. (PMID: 12510196) Chang P … Stearns T (Nature cell biology 2003) 3 22 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for TUBE1 Gene
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- VectorBuilder custom plasmid, inducible vectors for TUBE1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TUBE1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 65 available TUBE1 Antibodies ranked by validation data
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- Overview of 115 available TUBE1 gene related products
Sources for TUBE1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
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