This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan... See more...

Aliases for TUBE1 Gene

Aliases for TUBE1 Gene

  • Tubulin Epsilon 1 2 3 5
  • TUBE 2 3 4
  • Tubulin Epsilon Chain 3 4
  • Epsilon-Tubulin 3 4
  • DJ142L7.2 2 3
  • Tubulin, Epsilon 1 2
  • FLJ22589 2
  • TUBE1 5

External Ids for TUBE1 Gene

Previous GeneCards Identifiers for TUBE1 Gene

  • GC06M112414
  • GC06M112437
  • GC06M112498
  • GC06M109966
  • GC06M112391

Summaries for TUBE1 Gene

Entrez Gene Summary for TUBE1 Gene

  • This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]

GeneCards Summary for TUBE1 Gene

TUBE1 (Tubulin Epsilon 1) is a Protein Coding gene. Diseases associated with TUBE1 include Chronic Frontal Sinusitis and Frontal Sinusitis. Among its related pathways are G-Beta Gamma Signaling and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB8.

Tocris Summary for TUBE1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Additional gene information for TUBE1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUBE1 Gene

Genomics for TUBE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TUBE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J112086 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 328 2.8 CEBPG CREB1 GATAD2A PRDM10 ZNF629 TFE3 RFX1 NFKBIZ POLR2A RCOR2 FAM229B TUBE1 lnc-TUBE1-1 MFSD4B ENSG00000220506 CCN6 FCF1P5 ENSG00000237234 BRD7P4 lnc-LAMA4-3-002
GH06J111477 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 26.2 +605.9 605872 8.7 ZNF221 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 REV3L TRAF3IP2-AS1 MFSD4B ENSG00000220506 BRD7P4 TUBE1 ENSG00000255389 FCF1P5 ENSG00000272356 TRAF3IP2
GH06J111600 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.2 +483.8 483806 7.1 ZNF221 GATAD2A PRDM10 TFE3 LEF1 IKZF1 NFKBIZ ZNF692 RCOR2 POLR2A TRAF3IP2 ENSG00000255389 CNN2P9 TUBE1 MFSD4B ENSG00000220506 BRD7P4 REV3L TRAF3IP2-AS1
GH06J111563 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.9 +521.1 521144 6.3 CEBPG CTCF PRDM10 ZNF629 ZNF692 ZIC2 ZSCAN4 PKNOX1 POLR2A PATZ1 lnc-REV3L-3 MFSD4B ENSG00000220506 REV3L ENSG00000255389 TRAF3IP2-AS1 TRAF3IP2 TUBE1 FCF1P5 BRD7P4
GH06J111870 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +215.1 215059 4.7 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 ZNF512 RFX1 SIX5 IKZF1 FYN LOC102724646 lnc-WISP3-2 LINC02527 ENSG00000272356 TUBE1 REV3L lnc-TRAF3IP2-2 TRAF3IP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUBE1

Top Transcription factor binding sites by QIAGEN in the TUBE1 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • CREB
  • ER-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • MyoD
  • NF-1
  • Pax-4a

Genomic Locations for TUBE1 Gene

Genomic Locations for TUBE1 Gene
chr6:112,070,663-112,087,529
(GRCh38/hg38)
Size:
16,867 bases
Orientation:
Minus strand
chr6:112,391,860-112,408,751
(GRCh37/hg19)
Size:
16,892 bases
Orientation:
Minus strand

Genomic View for TUBE1 Gene

Genes around TUBE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBE1 Gene

Proteins for TUBE1 Gene

  • Protein details for TUBE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT0-TBE_HUMAN
    Recommended name:
    Tubulin epsilon chain
    Protein Accession:
    Q9UJT0
    Secondary Accessions:
    • Q5H8W8
    • Q8NEG3

    Protein attributes for TUBE1 Gene

    Size:
    475 amino acids
    Molecular mass:
    52932 Da
    Quaternary structure:
    • Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.

neXtProt entry for TUBE1 Gene

Post-translational modifications for TUBE1 Gene

  • Glycosylation at Asn401
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for TUBE1 Gene

No data available for DME Specific Peptides for TUBE1 Gene

Domains & Families for TUBE1 Gene

Gene Families for TUBE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for TUBE1 Gene

Suggested Antigen Peptide Sequences for TUBE1 Gene

GenScript: Design optimal peptide antigens:
  • Epsilon-tubulin (TBE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJT0

UniProtKB/Swiss-Prot:

TBE_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBE1: view

Function for TUBE1 Gene

Phenotypes From GWAS Catalog for TUBE1 Gene

Gene Ontology (GO) - Molecular Function for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS,IBA 21873635
GO:0005525 GTP binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with TUBE1: view
genes like me logo Genes that share phenotypes with TUBE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBE1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBE1 Gene

Localization for TUBE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBE1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with pericentriolar material. {ECO:0000269 PubMed:10620804}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
plasma membrane 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material TAS 10620804
GO:0005737 cytoplasm IBA 21873635
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA,IBA 21873635
genes like me logo Genes that share ontologies with TUBE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TUBE1 Gene

Pathways & Interactions for TUBE1 Gene

PathCards logo

SuperPathways for TUBE1 Gene

SuperPathway Contained pathways
1 Sertoli-Sertoli Cell Junction Dynamics
.38
.38
.36
2 Nanog in Mammalian ESC Pluripotency
.59
3 PAK Pathway
.36
4 G-Beta Gamma Signaling
.32
5 ERK Signaling
.51
genes like me logo Genes that share pathways with TUBE1: view

Pathways by source for TUBE1 Gene

9 Qiagen pathways for TUBE1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Epithelial Adherens Junctions
  • Epithelial Tight Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Hedgehog Signaling in Mammals

Gene Ontology (GO) - Biological Process for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0007017 microtubule-based process IEA,IBA 21873635
GO:0007098 centrosome cycle TAS 10620804
genes like me logo Genes that share ontologies with TUBE1: view

No data available for SIGNOR curated interactions for TUBE1 Gene

Drugs & Compounds for TUBE1 Gene

(4) Drugs for TUBE1 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 189
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
MPC 6827 hydrochloride Pharma Potent microtubule inhibitor, Inhibitor of microtubule polymerization; antimitotic and antitumor 0
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBE1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Noscapine hydrochloride
912-60-7
taxol
Agonist 33069-62-4

(5) Tocris Compounds for TUBE1 Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBE1: view

Transcripts for TUBE1 Gene

mRNA/cDNA for TUBE1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBE1

Alternative Splicing Database (ASD) splice patterns (SP) for TUBE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for TUBE1 Gene

GeneLoc Exon Structure for
TUBE1

Expression for TUBE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUBE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBE1 Gene

This gene is overexpressed in Monocytes (48.2), Testis (10.9), and Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBE1 Gene



Protein tissue co-expression partners for TUBE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUBE1

SOURCE GeneReport for Unigene cluster for TUBE1 Gene:

Hs.34851

Evidence on tissue expression from TISSUES for TUBE1 Gene

  • Nervous system(3.3)
  • Skin(2.5)
  • Kidney(2.4)
  • Lung(2.4)
  • Liver(2.3)
  • Heart(2.2)
  • Muscle(2.2)
  • Intestine(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with TUBE1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBE1 Gene

Orthologs for TUBE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TUBE1 30 31
  • 99.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TUBE1 30 31
  • 91.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tube1 30 17 31
  • 85.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TUBE1 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TUBE1 31
  • 84 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tube1 30
  • 82.96 (n)
Oppossum
(Monodelphis domestica)
Mammalia TUBE1 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TUBE1 30 31
  • 78.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TUBE1 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tube1 30
  • 74.59 (n)
Zebrafish
(Danio rerio)
Actinopterygii tube1 30 31 31
  • 67.31 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG32396 31
  • 28 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea tbb-6 31
  • 30 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 67 (a)
OneToOne
Species where no ortholog for TUBE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TUBE1 Gene

ENSEMBL:
Gene Tree for TUBE1 (if available)
TreeFam:
Gene Tree for TUBE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUBE1: view image

Paralogs for TUBE1 Gene

(27) SIMAP similar genes for TUBE1 Gene using alignment to 3 proteins:

  • TBE_HUMAN
  • S4R3K3_HUMAN
  • S4R424_HUMAN

Pseudogenes.org Pseudogenes for TUBE1 Gene

genes like me logo Genes that share paralogs with TUBE1: view

Variants for TUBE1 Gene

Additional dbSNP identifiers (rs#s) for TUBE1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TUBE1 Gene

Variant ID Type Subtype PubMed ID
esv3366325 CNV insertion 20981092
nsv950495 CNV duplication 24416366

Variation tolerance for TUBE1 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUBE1 Gene

Disorders for TUBE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TUBE1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search TUBE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TUBE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TUBE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBE1 Gene

Publications for TUBE1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P … Stearns T (Nature cell biology 2000) 2 3 4 23
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Epsilon-tubulin is required for centriole duplication and microtubule organization. (PMID: 12510196) Chang P … Stearns T (Nature cell biology 2003) 3 23
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

Products for TUBE1 Gene

Sources for TUBE1 Gene