Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
TUBE1 (Tubulin Epsilon 1) is a Protein Coding gene. Diseases associated with TUBE1 include Chronic Frontal Sinusitis and Frontal Sinusitis. Among its related pathways are G-Beta Gamma Signaling and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB8.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA | -- |
GO:0005200 | structural constituent of cytoskeleton | TAS,IBA | 21873635 |
GO:0005525 | GTP binding | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000242 | pericentriolar material | TAS | 10620804 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005815 | microtubule organizing center | IEA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005874 | microtubule | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
2 | Nanog in Mammalian ESC Pluripotency |
14-3-3 Induced Intracellular Signaling
.59
|
|
3 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
4 | G-Beta Gamma Signaling |
Hedgehog Signaling in Mammals
.32
|
|
5 | ERK Signaling |
Molecular Mechanisms of Cancer
.51
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0000278 | mitotic cell cycle | IBA | 21873635 |
GO:0007017 | microtubule-based process | IEA,IBA | 21873635 |
GO:0007098 | centrosome cycle | TAS | 10620804 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Vinblastine | Approved | Pharma | Target, adduct | 189 | ||
Nocodazole | Experimental | Pharma | Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor | 0 | ||
MPC 6827 hydrochloride | Pharma | Potent microtubule inhibitor, Inhibitor of microtubule polymerization; antimitotic and antitumor | 0 | |||
Vinblastine sulfate | Pharma | Anti-mitotic agent, Disrupts microtubules | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Noscapine hydrochloride |
|
912-60-7 |
|
|
||
taxol |
|
Agonist | 33069-62-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
MPC 6827 hydrochloride | Inhibitor of microtubule polymerization; antimitotic and antitumor | 917369-31-4 |
Nocodazole | Microtubule inhibitor | 31430-18-9 |
Noscapine hydrochloride | Tubulin inhibitor; induces apoptosis | 912-60-7 |
Taxol | Promotes assembly and inhibits disassembly of microtubules | 33069-62-4 |
Vinblastine sulfate | Disrupts microtubules | 143-67-9 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TUBE1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TUBE1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tube1 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TUBE1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TUBE1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tube1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TUBE1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TUBE1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TUBE1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tube1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tube1 30 31 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG32396 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | tbb-6 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3366325 | CNV | insertion | 20981092 |
nsv950495 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chronic frontal sinusitis |
|
|
frontal sinusitis |
|
|
joubert syndrome 1 |
|
|