Aliases for TUBD1 Gene

Aliases for TUBD1 Gene

  • Tubulin Delta 1 2 3 5
  • Tubulin Delta Chain 3 4
  • Delta-Tubulin 3 4
  • TUBD 3 4
  • Tubulin, Delta 1 2

External Ids for TUBD1 Gene

Previous GeneCards Identifiers for TUBD1 Gene

  • GC17M057786
  • GC17M060386
  • GC17M058278
  • GC17M058412
  • GC17M055291
  • GC17M057936
  • GC17M053309

Summaries for TUBD1 Gene

GeneCards Summary for TUBD1 Gene

TUBD1 (Tubulin Delta 1) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot Summary for TUBD1 Gene

  • Acts as a positive regulator of hedgehog signaling and regulates ciliary function.

Tocris Summary for TUBD1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Additional gene information for TUBD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUBD1 Gene

Genomics for TUBD1 Gene

GeneHancer (GH) Regulatory Elements for TUBD1 Gene

Promoters and enhancers for TUBD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBD1 gene promoter:
  • CREB
  • deltaCREB
  • E2F
  • E2F-1
  • Evi-1
  • NF-1
  • NF-1/L
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • YY1

Genomic Locations for TUBD1 Gene

Genomic Locations for TUBD1 Gene
chr17:59,859,479-59,892,945
(GRCh38/hg38)
Size:
33,467 bases
Orientation:
Minus strand
chr17:57,936,840-57,970,306
(GRCh37/hg19)
Size:
33,467 bases
Orientation:
Minus strand

Genomic View for TUBD1 Gene

Genes around TUBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBD1 Gene

Proteins for TUBD1 Gene

  • Protein details for TUBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT1-TBD_HUMAN
    Recommended name:
    Tubulin delta chain
    Protein Accession:
    Q9UJT1
    Secondary Accessions:
    • B4DPT8
    • B4DW01
    • D3DU02
    • E9PCA7
    • E9PCQ8
    • Q5KU36
    • Q9BWG9
    • Q9H7Z8

    Protein attributes for TUBD1 Gene

    Size:
    453 amino acids
    Molecular mass:
    51034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TUBD1 Gene

neXtProt entry for TUBD1 Gene

Post-translational modifications for TUBD1 Gene

  • Ubiquitination at Lys47 and Lys79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBD1 Gene

Domains & Families for TUBD1 Gene

Gene Families for TUBD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TUBD1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57211, highly similar to Tubulin delta chain (B4DW01_HUMAN)
  • Delta-tubulin (TBD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJT1

UniProtKB/Swiss-Prot:

TBD_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBD1: view

Function for TUBD1 Gene

Molecular function for TUBD1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.

Phenotypes From GWAS Catalog for TUBD1 Gene

Gene Ontology (GO) - Molecular Function for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IBA 21873635
GO:0005525 GTP binding IBA 21873635
genes like me logo Genes that share ontologies with TUBD1: view
genes like me logo Genes that share phenotypes with TUBD1: view

Animal Model Products

CRISPR Products

miRNA for TUBD1 Gene

miRTarBase miRNAs that target TUBD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBD1 Gene

Localization for TUBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBD1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Note=Associated with centrioles. Both cytoplasmic and nuclear. In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head. {ECO:0000250 UniProtKB:Q9R1K7}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBD1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005814 centriole TAS,IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TUBD1: view

Pathways & Interactions for TUBD1 Gene

PathCards logo

SuperPathways for TUBD1 Gene

SuperPathway Contained pathways
1 Sertoli-Sertoli Cell Junction Dynamics
.38
.38
.36
2 PAK Pathway
.36
3 G-Beta Gamma Signaling
.32
4 ERK Signaling
.51
5 Remodeling of Adherens Junctions
-
genes like me logo Genes that share pathways with TUBD1: view

Pathways by source for TUBD1 Gene

7 Qiagen pathways for TUBD1 Gene
  • Epithelial Adherens Junctions
  • Epithelial Tight Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Hedgehog Signaling in Mammals
  • Molecular Mechanisms of Cancer

SIGNOR curated interactions for TUBD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IBA 21873635
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Drugs & Compounds for TUBD1 Gene

(4) Drugs for TUBD1 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 215
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
MPC 6827 hydrochloride Pharma Potent microtubule inhibitor, Inhibitor of microtubule polymerization; antimitotic and antitumor 0
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBD1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Noscapine hydrochloride
912-60-7
taxol
Agonist 33069-62-4

(5) Tocris Compounds for TUBD1 Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBD1: view

Transcripts for TUBD1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - -

Relevant External Links for TUBD1 Gene

GeneLoc Exon Structure for
TUBD1
ECgene alternative splicing isoforms for
TUBD1

Expression for TUBD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TUBD1 Gene:

TUBD1

SOURCE GeneReport for Unigene cluster for TUBD1 Gene:

Hs.463638

Evidence on tissue expression from TISSUES for TUBD1 Gene

  • Eye(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with TUBD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBD1 Gene

Orthologs for TUBD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBD1 33 32
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TUBD1 33 32
  • 91.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TUBD1 33 32
  • 90.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tubd1 17 33 32
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Tubd1 32
  • 82.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TUBD1 33
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBD1 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUBD1 33 32
  • 73.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBD1 33
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubd1 32
  • 72.21 (n)
Str.12654 32
African clawed frog
(Xenopus laevis)
Amphibia tubd1-A-prov 32
zebrafish
(Danio rerio)
Actinopterygii tubd1 33 32
  • 62.78 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbg-1 33
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 33
  • 21 (a)
OneToMany
Species where no ortholog for TUBD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBD1 Gene

ENSEMBL:
Gene Tree for TUBD1 (if available)
TreeFam:
Gene Tree for TUBD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUBD1: view image

Paralogs for TUBD1 Gene

(5) SIMAP similar genes for TUBD1 Gene using alignment to 5 proteins:

  • TBD_HUMAN
  • K7EKE2_HUMAN
  • K7EMW6_HUMAN
  • K7EPQ0_HUMAN
  • K7EQN9_HUMAN
genes like me logo Genes that share paralogs with TUBD1: view

Variants for TUBD1 Gene

Sequence variations from dbSNP and Humsavar for TUBD1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000021445 -- 59,891,985(-) A/T intron_variant
rs1000207163 -- 59,869,174(-) G/A/C intron_variant
rs1000312990 -- 59,862,850(-) G/A/C intron_variant
rs1000333130 -- 59,874,639(-) A/C/G coding_sequence_variant, intron_variant, synonymous_variant
rs1000336935 -- 59,893,558(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBD1 Gene

Variant ID Type Subtype PubMed ID
esv2716085 CNV deletion 23290073
esv3554613 CNV deletion 23714750
esv3640914 CNV gain 21293372
nsv1116228 CNV deletion 24896259

Variation tolerance for TUBD1 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.32; 95.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBD1 Gene

Human Gene Mutation Database (HGMD)
TUBD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBD1 Gene

Disorders for TUBD1 Gene

Additional Disease Information for TUBD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TUBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBD1 Gene

Publications for TUBD1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P … Stearns T (Nature cell biology 2000) 2 3 4 23 56
  2. Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis. (PMID: 15081367) Kato A … Todokoro K (Developmental biology 2004) 3 4 23 56
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 43 56
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for TUBD1 Gene