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Aliases for TUBD1 Gene
Aliases for TUBD1 Gene
External Ids for TUBD1 Gene
- HGNC: 16811
- NCBI Entrez Gene: 51174
- Ensembl: ENSG00000108423
- OMIM®: 607344
- UniProtKB/Swiss-Prot: Q9UJT1
Previous GeneCards Identifiers for TUBD1 Gene
- GC17M057786
- GC17M060386
- GC17M058278
- GC17M058412
- GC17M055291
- GC17M057936
- GC17M053309
Summaries for TUBD1 Gene
GeneCards Summary for TUBD1 Gene
TUBD1 (Tubulin Delta 1) is a Protein Coding gene. Diseases associated with TUBD1 include Seckel Syndrome 7 and Orofaciodigital Syndrome Ix. Among its related pathways are Remodeling of Adherens Junctions and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB8.
UniProtKB/Swiss-Prot Summary for TUBD1 Gene
-
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
-
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).
Additional gene information for TUBD1 Gene
No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUBD1 Gene
Genomics for TUBD1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TUBD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TUBD1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUBD1
- Top Transcription factor binding sites by QIAGEN in the TUBD1 gene promoter:
-
- CREB
- deltaCREB
- E2F
- E2F-1
- Evi-1
- NF-1
- NF-1/L
- POU3F2
- POU3F2 (N-Oct-5a)
- YY1
Genomic Locations for TUBD1 Gene
Latest Assembly
- chr17:59,859,467-59,892,948
- (GRCh38/hg38)
- Size:
- 33,482 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:57,936,840-57,970,304
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 33,465 bases
- Orientation:
- Minus strand
Genomic View for TUBD1 Gene
Genes around TUBD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.1 by HGNC
- 17q23.1 by Entrez Gene
- 17q23.1 by Ensembl
TUBD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TUBD1 Gene
Proteins for TUBD1 Gene
-
Protein details for TUBD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJT1-TBD_HUMAN
- Recommended name:
- Tubulin delta chain
- Protein Accession:
- Q9UJT1
- B4DPT8
- B4DW01
- D3DU02
- E9PCA7
- E9PCQ8
- Q5KU36
- Q9BWG9
- Q9H7Z8
Protein attributes for TUBD1 Gene
- Size:
- 453 amino acids
- Molecular mass:
- 51034 Da
- Quaternary structure:
-
- Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.
Protein Expression for TUBD1 Gene
Post-translational modifications for TUBD1 Gene
Other Protein References for TUBD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ TUBD1 Antibody
- Novus Biologicals Antibodies for TUBD1
- Invitrogen Antibodies for TUBD1 (AFLGC-TUBD1)
-
Boster Bio Antibodies for TUBD1
-
Custom Antibody ServicesProSci Antibodies for TUBD1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TUBD1
Protein products for research
-
OriGene Purified Proteins for TUBD1
- Search Origene for MassSpec and Protein Over-expression Lysates for TUBD1
- Origene Custom Protein Services for TUBD1
-
Abcam proteins for TUBD1
Assay products for research
No data available for DME Specific Peptides for TUBD1 Gene
Domains & Families for TUBD1 Gene
Gene Families for TUBD1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for TUBD1 Gene
- InterPro:
- Blocks:
-
- Delta tubulin signature
Suggested Antigen Peptide Sequences for TUBD1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57211, highly similar to Tubulin delta chain (B4DW01_HUMAN)
- Delta-tubulin (TBD_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UJT1- Family:
-
- Belongs to the tubulin family.
Function for TUBD1 Gene
Molecular function for TUBD1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Phenotypes From GWAS Catalog for TUBD1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | IBA | 21873635 |
| GO:0005525 | GTP binding | IBA | 21873635 |
Phenotypes for TUBD1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TUBD1 - Starting at $85 >
- * TUBD1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TUBD1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TUBD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TUBD1
miRNA for TUBD1 Gene
- miRTarBase miRNAs that target TUBD1
-
- hsa-miR-26b-5p (MIRT028800)
- hsa-miR-1276 (MIRT449868)
- hsa-miR-376a-2-5p (MIRT573334)
- hsa-miR-7150 (MIRT573335)
- hsa-miR-4451 (MIRT573336)
- hsa-miR-4650-3p (MIRT573337)
- hsa-miR-5681a (MIRT573338)
- hsa-miR-3529-5p (MIRT573339)
- hsa-miR-379-5p (MIRT573340)
- hsa-miR-96-5p (MIRT573341)
- hsa-miR-182-5p (MIRT573342)
- hsa-miR-1271-5p (MIRT573343)
- hsa-miR-2054 (MIRT614116)
- hsa-miR-190a-3p (MIRT614117)
- hsa-miR-380-3p (MIRT614118)
- hsa-miR-411-3p (MIRT614119)
- hsa-miR-379-3p (MIRT614120)
- hsa-miR-4495 (MIRT614121)
- hsa-miR-5011-5p (MIRT614122)
- hsa-miR-4789-3p (MIRT614123)
- hsa-miR-8485 (MIRT614124)
- hsa-miR-3941 (MIRT628731)
- hsa-miR-603 (MIRT628732)
- hsa-miR-362-3p (MIRT628733)
- hsa-miR-329-3p (MIRT628734)
- hsa-miR-6783-3p (MIRT665574)
- hsa-miR-1343-3p (MIRT665575)
- hsa-miR-23b-5p (MIRT665576)
- hsa-miR-23a-5p (MIRT665577)
- hsa-miR-4284 (MIRT665578)
- hsa-miR-6829-3p (MIRT665579)
- hsa-miR-6791-3p (MIRT665580)
- hsa-miR-2276-3p (MIRT665581)
- hsa-miR-4638-5p (MIRT665582)
- hsa-miR-1307-3p (MIRT665583)
- hsa-miR-1304-3p (MIRT665584)
- hsa-miR-6741-3p (MIRT665585)
- hsa-miR-1281 (MIRT665586)
- hsa-miR-6852-5p (MIRT665587)
- hsa-miR-939-3p (MIRT665588)
- hsa-miR-660-3p (MIRT665589)
- hsa-miR-4485-5p (MIRT665590)
- hsa-miR-6890-3p (MIRT665591)
- hsa-miR-598-3p (MIRT665592)
- hsa-miR-7151-3p (MIRT706821)
- hsa-miR-5095 (MIRT706822)
- hsa-miR-365b-5p (MIRT706823)
- hsa-miR-365a-5p (MIRT706824)
- hsa-miR-8052 (MIRT706825)
- hsa-miR-3199 (MIRT706826)
- hsa-miR-6720-3p (MIRT706827)
- hsa-miR-6778-3p (MIRT706828)
- hsa-miR-4258 (MIRT706829)
- hsa-miR-4740-3p (MIRT706830)
- hsa-miR-6715b-5p (MIRT706831)
- hsa-miR-4269 (MIRT706832)
- hsa-miR-4438 (MIRT706833)
- hsa-miR-620 (MIRT717935)
- hsa-miR-4531 (MIRT717937)
- hsa-miR-1270 (MIRT717938)
- hsa-miR-550a-3p (MIRT717939)
- hsa-miR-200c-5p (MIRT717940)
- hsa-miR-6879-3p (MIRT717941)
- hsa-miR-139-3p (MIRT717942)
- hsa-miR-4524a-3p (MIRT717943)
- hsa-miR-550b-3p (MIRT717944)
- hsa-miR-215-3p (MIRT717945)
- hsa-miR-6773-3p (MIRT717946)
- hsa-miR-3664-5p (MIRT717947)
- hsa-miR-514a-5p (MIRT717948)
- hsa-miR-4714-5p (MIRT717949)
- hsa-miR-122-5p (MIRT761358)
- hsa-miR-143-5p (MIRT762704)
- hsa-miR-3135b (MIRT764955)
- hsa-miR-3652 (MIRT766316)
- hsa-miR-4430 (MIRT768951)
- hsa-miR-4634 (MIRT770506)
- hsa-miR-504-3p (MIRT773078)
- hsa-miR-5693 (MIRT775046)
- hsa-miR-5698 (MIRT775171)
- hsa-miR-6499-3p (MIRT776401)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TUBD1
- Browse OriGene Inhibitory RNA Products For TUBD1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBD1
Clone products for research
- Applied Biological Materials (abm): Clones for TUBD1 - Starting at $45 >
- * TUBD1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207275
- MR207275
- MR207275L3
- MR207275L4
- MR229990
- MR230158
- MR230159
- RC220591
- RC220591L3
- RC220591L4
- RC230791
- RC230791L3
- RC230791L4
- RC230822
- RC230822L3
- RC230822L4
- RC231084
- RC231084L3
- RC231084L4
- RC231177
- RC231177L3
- RC231177L4
- RC231207
- RC231207L3
- RC231207L4
- RG220591
- RG230791
- RG230822
- RG231084
- RG231177
- RG231207
- RR209179
- RR209179L3
- RR209179L4
- MR207275L3V
- MR207275L4V
- RC220591L3V
- RC220591L4V
- RC230791L3V
- RC230791L4V
- RC230822L3V
- RC230822L4V
- RC231084L3V
- RC231084L4V
- RC231177L3V
- RC231177L4V
- RC231207L3V
- RC231207L4V
- RR209179L3V
- RR209179L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TUBD1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TUBD1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBD1 Gene
Localization for TUBD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TUBD1 Gene
- Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Note=Associated with centrioles. Both cytoplasmic and nuclear. In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head. {ECO:0000250 UniProtKB:Q9R1K7}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005814 | centriole | TAS,IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for TUBD1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
| 2 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
| 3 | G-Beta Gamma Signaling |
Hedgehog Signaling in Mammals
.32
|
|
| 4 | ERK Signaling |
Molecular Mechanisms of Cancer
.51
|
|
| 5 | Remodeling of Adherens Junctions |
Remodeling of Adherens Junctions
-
|
|
Pathways by source for TUBD1 Gene
7 Qiagen pathways for TUBD1 Gene
- Epithelial Adherens Junctions
- Epithelial Tight Junctions
- Germ Cell-Sertoli Cell Junction Dynamics
- Hedgehog Signaling in Mammals
- Molecular Mechanisms of Cancer
Interacting Proteins for TUBD1 Gene
GPS-Prot Interaction Network for TUBD1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
| GO:0000278 | mitotic cell cycle | IBA | 21873635 |
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0007017 | microtubule-based process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for TUBD1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vinblastine | Approved | Pharma | Target, adduct | 195 | ||
| Nocodazole | Experimental | Pharma | Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor | 0 | ||
| MPC 6827 hydrochloride | Pharma | Potent microtubule inhibitor, Inhibitor of microtubule polymerization; antimitotic and antitumor | 0 | |||
| Vinblastine sulfate | Pharma | Anti-mitotic agent, Disrupts microtubules | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Noscapine hydrochloride |
|
912-60-7 |
|
|
||
| taxol |
|
33069-62-4 |
|
|
(5) Tocris Compounds for TUBD1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| MPC 6827 hydrochloride | Inhibitor of microtubule polymerization; antimitotic and antitumor | 917369-31-4 |
| Nocodazole | Microtubule inhibitor | 31430-18-9 |
| Noscapine hydrochloride | Tubulin inhibitor; induces apoptosis | 912-60-7 |
| Taxol | Promotes assembly and inhibits disassembly of microtubules | 33069-62-4 |
| Vinblastine sulfate | Disrupts microtubules | 143-67-9 |
Transcripts for TUBD1 Gene
mRNA/cDNA for TUBD1 Gene
- 6 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000325752 2491 nts (view in UCSC)
- ENST00000340993 1769 nts (view in UCSC)
- ENST00000346141 1490 nts (view in UCSC)
- ENST00000376094 1154 nts (view in UCSC)
- ENST00000394239 1680 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TUBD1 - Starting at $85 >
- * TUBD1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TUBD1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TUBD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TUBD1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TUBD1
- Browse OriGene Inhibitory RNA Products For TUBD1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBD1
Clone products for research
- Applied Biological Materials (abm): Clones for TUBD1 - Starting at $45 >
- * TUBD1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207275
- MR207275
- MR207275L3
- MR207275L4
- MR229990
- MR230158
- MR230159
- RC220591
- RC220591L3
- RC220591L4
- RC230791
- RC230791L3
- RC230791L4
- RC230822
- RC230822L3
- RC230822L4
- RC231084
- RC231084L3
- RC231084L4
- RC231177
- RC231177L3
- RC231177L4
- RC231207
- RC231207L3
- RC231207L4
- RG220591
- RG230791
- RG230822
- RG231084
- RG231177
- RG231207
- RR209179
- RR209179L3
- RR209179L4
- MR207275L3V
- MR207275L4V
- RC220591L3V
- RC220591L4V
- RC230791L3V
- RC230791L4V
- RC230822L3V
- RC230822L4V
- RC231084L3V
- RC231084L4V
- RC231177L3V
- RC231177L4V
- RC231207L3V
- RC231207L4V
- RR209179L3V
- RR209179L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TUBD1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TUBD1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - |
Relevant External Links for TUBD1 Gene
- GeneLoc Exon Structure for
- TUBD1
Expression for TUBD1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBD1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUBD1
SOURCE GeneReport for Unigene cluster for TUBD1 Gene:
Hs.463638Evidence on tissue expression from TISSUES for TUBD1 Gene
- Eye(4.2)
- Stomach(4.1)
Primer products for research
-
OriGene qPCR primer pairs for TUBD1
-
OriGene qPCR primer pairs and template standards for TUBD1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBD1 Gene
Orthologs for TUBD1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TUBD1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TUBD1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TUBD1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tubd1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tubd1 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TUBD1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TUBD1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TUBD1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TUBD1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tubd1 29 |
|
||
| Str.12654 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | tubd1-A-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tubd1 29 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | tbg-1 30 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TUB4 30 |
|
OneToMany |
- Species where no ortholog for TUBD1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TUBD1 Gene
- ENSEMBL:
- Gene Tree for TUBD1 (if available)
- TreeFam:
- Gene Tree for TUBD1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TUBD1: view image
- Alliance of Genome Resources:
- Additional Orthologs for TUBD1
Paralogs for TUBD1 Gene
Paralogs for TUBD1 Gene
(5) SIMAP similar genes for TUBD1 Gene using alignment to 5 proteins:
- TBD_HUMAN
- K7EKE2_HUMAN
- K7EMW6_HUMAN
- K7EPQ0_HUMAN
- K7EQN9_HUMAN
Variants for TUBD1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUBD1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs76112765 | Benign: not provided | 59,890,847(-) |
A/G NM_016261.4(TUBD1):c.156T>C (p.Ser52=) |
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON | |
| rs1292053 | -- |
p.Met76Thr |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2716085 | CNV | deletion | 23290073 |
| esv3554613 | CNV | deletion | 23714750 |
| esv3640914 | CNV | gain | 21293372 |
| nsv1116228 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.32;
95.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TUBD1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBD1 Gene
Disorders for TUBD1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| seckel syndrome 7 |
|
|
| orofaciodigital syndrome ix |
|
|
| cone-rod dystrophy 20 |
|
|
| joubert syndrome 1 |
|
|
Search TUBD1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TUBD1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TUBD1 Gene
Publications for TUBD1 Gene
- Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P … Stearns T (Nature cell biology 2000) 2 3 4 22
- Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis. (PMID: 15081367) Kato A … Todokoro K (Developmental biology 2004) 3 4 22
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 40
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for TUBD1 Gene
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- antibodies-online: Show 12 available TUBD1 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for TUBD1
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- Search for TUBD1 Proteins at ProSci
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- Boster Bio Antibodies for TUBD1
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Sources for TUBD1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33)