Aliases for TUBB8 Gene
External Ids for TUBB8 Gene
Previous GeneCards Identifiers for TUBB8 Gene
The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]
GeneCards Summary for TUBB8 Gene
TUBB8 (Tubulin Beta 8 Class VIII) is a Protein Coding gene. Diseases associated with TUBB8 include Oocyte Maturation Defect 2 and Female Infertility Due To Oocyte Meiotic Arrest. Among its related pathways are Gap junction and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB8B.
UniProtKB/Swiss-Prot Summary for TUBB8 Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871).