Aliases for TUBB6 Gene
External Ids for TUBB6 Gene
Previous GeneCards Identifiers for TUBB6 Gene
GeneCards Summary for TUBB6 Gene
TUBB6 (Tubulin Beta 6 Class V) is a Protein Coding gene. Diseases associated with TUBB6 include Facial Palsy, Congenital, With Ptosis And Velopharyngeal Dysfunction and Ptosis. Among its related pathways are Phagosome and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB3.
UniProtKB/Swiss-Prot Summary for TUBB6 Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).