Aliases for TUBB2B Gene
External Ids for TUBB2B Gene
Previous GeneCards Identifiers for TUBB2B Gene
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
GeneCards Summary for TUBB2B Gene
TUBB2B (Tubulin Beta 2B Class IIb) is a Protein Coding gene. Diseases associated with TUBB2B include Cortical Dysplasia, Complex, With Other Brain Malformations 7 and Tubulinopathy-Associated Dysgyria. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB2A.
UniProtKB/Swiss-Prot Summary for TUBB2B Gene
Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910).
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).