Aliases for TUBAL3 Gene

Aliases for TUBAL3 Gene

  • Tubulin Alpha Like 3 2 3 5
  • Tubulin Alpha Chain-Like 3 3 4
  • Tubulin, Alpha-Like 3 2
  • FLJ21665 2
  • TUBAL3 5

External Ids for TUBAL3 Gene

Previous GeneCards Identifiers for TUBAL3 Gene

  • GC10M005390

Summaries for TUBAL3 Gene

GeneCards Summary for TUBAL3 Gene

TUBAL3 (Tubulin Alpha Like 3) is a Protein Coding gene. Among its related pathways are Apoptosis Modulation and Signaling and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA1B.

UniProtKB/Swiss-Prot Summary for TUBAL3 Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUBAL3 Gene

Genomics for TUBAL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TUBAL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J005402 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 266.5 +0.9 907 3 ZNF592 BHLHE40 TBP ARNT TAF9B ELF1 ZNF316 MYNN ZFP91 ATF1 TUBAL3 UCN3 piR-31321-001
GH10J005486 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 259.3 -83.5 -83456 4.5 MYC IKZF1 ZNF217 SMAD5 MBD2 ZBTB7B CTBP1 NBN NKRF ELF1 TUBAL3 CALML3-AS1 FBH1 ENSG00000226647 TASOR2 CALML3 ENSG00000256462 AKR1E2 CALML5 UCN3
GH10J005444 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.7 -43.1 -43105 7 MYC NCOR1 IKZF1 ZNF600 ZNF580 ZNF592 KLF9 POLR2A CEBPA NFIC NET1 NRBF2P5 TUBAL3 ENSG00000232807 FBH1 TASOR2 CALML5 ENSG00000256462 CALML3 CALML3-AS1
GH10J005411 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.6 -8.3 -8273 2.6 SP1 IKZF1 NFIC POLR2A ZIC2 YY1 MXD4 SMAD5 SIN3A MBD2 NET1 NONHSAG005096.2 TUBAL3 UCN3 CALML5 piR-30287
GH10J005289 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 16.6 +111.0 110982 8.8 NCOR1 ZNF592 CEBPA REST CTCF CEBPB BHLHE40 HOMEZ EP300 THAP11 LINC02561 lnc-UCN3-3 TUBAL3 UCN3 ENSG00000239142 AKR1C3 AKR1E2 lnc-TUBAL3-1 AKR1C4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBAL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUBAL3

Top Transcription factor binding sites by QIAGEN in the TUBAL3 gene promoter:
  • C/EBPalpha
  • E2F
  • E2F-1
  • GATA-1
  • Gfi-1
  • Lmo2
  • NF-1
  • NF-1/L
  • STAT5B
  • YY1

Genomic Locations for TUBAL3 Gene

Latest Assembly
chr10:5,393,101-5,404,828
(GRCh38/hg38)
Size:
11,728 bases
Orientation:
Minus strand

Previous Assembly
chr10:5,435,064-5,446,791
(GRCh37/hg19 by Entrez Gene)
Size:
11,728 bases
Orientation:
Minus strand

chr10:5,435,061-5,446,793
(GRCh37/hg19 by Ensembl)
Size:
11,733 bases
Orientation:
Minus strand

Genomic View for TUBAL3 Gene

Genes around TUBAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBAL3 Gene

Proteins for TUBAL3 Gene

  • Protein details for TUBAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHL2-TBAL3_HUMAN
    Recommended name:
    Tubulin alpha chain-like 3
    Protein Accession:
    A6NHL2
    Secondary Accessions:
    • B4DKL2
    • Q4QQJ5
    • Q9H6Z0

    Protein attributes for TUBAL3 Gene

    Size:
    446 amino acids
    Molecular mass:
    49909 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Alternative splice isoforms for TUBAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBAL3 Gene

Post-translational modifications for TUBAL3 Gene

  • Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.
  • Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBAL3 Gene

No data available for DME Specific Peptides for TUBAL3 Gene

Domains & Families for TUBAL3 Gene

Gene Families for TUBAL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TUBAL3 Gene

GenScript: Design optimal peptide antigens:
  • Tubulin alpha chain-like 3 (TBAL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NHL2

UniProtKB/Swiss-Prot:

TBAL3_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBAL3: view

Function for TUBAL3 Gene

Molecular function for TUBAL3 Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Phenotypes From GWAS Catalog for TUBAL3 Gene

Gene Ontology (GO) - Molecular Function for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IBA 21873635
GO:0005525 GTP binding IBA 21873635
genes like me logo Genes that share ontologies with TUBAL3: view
genes like me logo Genes that share phenotypes with TUBAL3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBAL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBAL3 Gene

Localization for TUBAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBAL3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBAL3 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
plasma membrane 1
extracellular 1
nucleus 0

Gene Ontology (GO) - Cellular Components for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IBA 21873635
genes like me logo Genes that share ontologies with TUBAL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TUBAL3 Gene

Pathways & Interactions for TUBAL3 Gene

genes like me logo Genes that share pathways with TUBAL3: view

Pathways by source for TUBAL3 Gene

10 GeneGo (Thomson Reuters) pathways for TUBAL3 Gene
  • Cell adhesion Gap junctions
  • Cell cycle_Spindle assembly and chromosome separation
  • Cytoskeleton remodeling Keratin filaments
  • Cytoskeleton remodeling Neurofilaments
  • Cytoskeleton remodeling Reverse signaling by ephrin B

Gene Ontology (GO) - Biological Process for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0007017 microtubule-based process IEA --
genes like me logo Genes that share ontologies with TUBAL3: view

No data available for SIGNOR curated interactions for TUBAL3 Gene

Drugs & Compounds for TUBAL3 Gene

(1) Drugs for TUBAL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with TUBAL3: view

Transcripts for TUBAL3 Gene

mRNA/cDNA for TUBAL3 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBAL3

Alternative Splicing Database (ASD) splice patterns (SP) for TUBAL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TUBAL3 Gene

GeneLoc Exon Structure for
TUBAL3

Expression for TUBAL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUBAL3 Gene

mRNA differential expression in normal tissues according to GTEx for TUBAL3 Gene

This gene is overexpressed in Colon - Transverse (x19.1), Small Intestine - Terminal Ileum (x14.2), and Kidney - Cortex (x8.3).

Protein differential expression in normal tissues from HIPED for TUBAL3 Gene

This gene is overexpressed in Brain (44.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBAL3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUBAL3

SOURCE GeneReport for Unigene cluster for TUBAL3 Gene:

Hs.163079

Evidence on tissue expression from TISSUES for TUBAL3 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with TUBAL3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBAL3 Gene

Orthologs for TUBAL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBAL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TUBAL3 29 30
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TUBAL3 29 30
  • 84.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tubal3 29 16 30
  • 81.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tubal3 29
  • 81.5 (n)
Cow
(Bos Taurus)
Mammalia TUBAL3 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TUBAL3 30
  • 72 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta alphaTub67C 30
  • 63 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea tba-7 30
  • 69 (a)
OneToMany
tba-6 30
  • 67 (a)
OneToMany
tba-8 30
  • 66 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB3 30
  • 65 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7910 30
  • 69 (a)
OneToOne
Species where no ortholog for TUBAL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for TUBAL3 Gene

ENSEMBL:
Gene Tree for TUBAL3 (if available)
TreeFam:
Gene Tree for TUBAL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUBAL3: view image
Alliance of Genome Resources:
Additional Orthologs for TUBAL3

Paralogs for TUBAL3 Gene

Variants for TUBAL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUBAL3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs11818372 Benign: not provided 5,394,453(-) C/Gp.Gln135His
NM_024803.3(TUBAL3):c.405G>C (p.Gln135His)
MISSENSE
rs12359438 Benign: not provided 5,394,387(-) C/T
NM_024803.3(TUBAL3):c.471G>A (p.Thr157=)
SYNONYMOUS
rs35744127 Benign: not provided 5,393,841(-) G/A
NM_024803.3(TUBAL3):c.1017C>T (p.Ile339=)
SYNONYMOUS
rs41289265 Uncertain Significance: not provided 5,394,020(-) C/T
NM_024803.3(TUBAL3):c.838G>A (p.Ala280Thr)
MISSENSE
rs570546258 Likely Benign: not provided 5,395,390(-) C/T
NM_024803.3(TUBAL3):c.333G>A (p.Ala111=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TUBAL3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TUBAL3 Gene

Variant ID Type Subtype PubMed ID
nsv1045141 CNV gain 25217958
nsv549886 CNV loss 21841781

Variation tolerance for TUBAL3 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBAL3 Gene

Human Gene Mutation Database (HGMD)
TUBAL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBAL3
Leiden Open Variation Database (LOVD)
TUBAL3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBAL3 Gene

Disorders for TUBAL3 Gene

Additional Disease Information for TUBAL3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TUBAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBAL3 Gene

Publications for TUBAL3 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 40
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  3. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. (PMID: 31501420) Liu Y … Sun F (Cell death & disease 2019) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3

Products for TUBAL3 Gene

Sources for TUBAL3 Gene