Aliases for TUBA1B Gene

Aliases for TUBA1B Gene

  • Tubulin Alpha 1b 2 3 5
  • Tubulin Alpha-Ubiquitous Chain 3 4
  • Tubulin, Alpha, Ubiquitous 2 3
  • Alpha-Tubulin Ubiquitous 3 4
  • Tubulin Alpha-1B Chain 3 4
  • Tubulin K-Alpha-1 3 4
  • K-ALPHA-1 2 3
  • Alpha Tubulin 3
  • TUBA1B 5

External Ids for TUBA1B Gene

Previous GeneCards Identifiers for TUBA1B Gene

  • GC12M047809
  • GC12M049523
  • GC12M046552

Summaries for TUBA1B Gene

GeneCards Summary for TUBA1B Gene

TUBA1B (Tubulin Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include Kenny-Caffey Syndrome and Interstitial Nephritis, Karyomegalic. Among its related pathways are Neuroscience and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA1A.

UniProtKB/Swiss-Prot Summary for TUBA1B Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Tocris Summary for TUBA1B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBA1B Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TUBA1B Gene

Genomics for TUBA1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TUBA1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBA1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TUBA1B

Top Transcription factor binding sites by QIAGEN in the TUBA1B gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • HNF-1
  • HNF-1A
  • p53
  • TBP

Genomic Locations for TUBA1B Gene

Genomic Locations for TUBA1B Gene
chr12:49,127,782-49,131,397
(GRCh38/hg38)
Size:
3,616 bases
Orientation:
Minus strand
chr12:49,521,565-49,525,304
(GRCh37/hg19)
Size:
3,740 bases
Orientation:
Minus strand

Genomic View for TUBA1B Gene

Genes around TUBA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA1B Gene

Proteins for TUBA1B Gene

  • Protein details for TUBA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68363-TBA1B_HUMAN
    Recommended name:
    Tubulin alpha-1B chain
    Protein Accession:
    P68363
    Secondary Accessions:
    • P04687
    • P05209
    • Q27I68
    • Q8WU19

    Protein attributes for TUBA1B Gene

    Size:
    451 amino acids
    Molecular mass:
    50152 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Three dimensional structures from OCA and Proteopedia for TUBA1B Gene

    Alternative splice isoforms for TUBA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBA1B Gene

Post-translational modifications for TUBA1B Gene

  • Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
  • Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).
  • Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
  • Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
  • Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.
  • [Tubulin alpha-1B chain]: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
  • [Detyrosinated tubulin alpha-1B chain]: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
  • Ubiquitination at Lys326 and Lys370
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBA1B Gene

Antibody Products

  • Abcam antibodies for TUBA1B

No data available for DME Specific Peptides for TUBA1B Gene

Domains & Families for TUBA1B Gene

Gene Families for TUBA1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUBA1B Gene

Suggested Antigen Peptide Sequences for TUBA1B Gene

GenScript: Design optimal peptide antigens:
  • TUBA1B protein (Q8WU19_HUMAN)
  • Tubulin alpha-ubiquitous chain (TBA1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P68363

UniProtKB/Swiss-Prot:

TBA1B_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA1B: view

Function for TUBA1B Gene

Molecular function for TUBA1B Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Phenotypes From GWAS Catalog for TUBA1B Gene

Gene Ontology (GO) - Molecular Function for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 12090300
GO:0005200 structural constituent of cytoskeleton IEA,IBA 21873635
genes like me logo Genes that share ontologies with TUBA1B: view
genes like me logo Genes that share phenotypes with TUBA1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBA1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBA1B Gene

Localization for TUBA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA1B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBA1B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA,TAS 12090300
GO:0005881 cytoplasmic microtubule IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with TUBA1B: view

Pathways & Interactions for TUBA1B Gene

PathCards logo

SuperPathways for TUBA1B Gene

genes like me logo Genes that share pathways with TUBA1B: view

Pathways by source for TUBA1B Gene

10 GeneGo (Thomson Reuters) pathways for TUBA1B Gene
  • Cell adhesion Gap junctions
  • Cell cycle_Spindle assembly and chromosome separation
  • Cytoskeleton remodeling Keratin filaments
  • Cytoskeleton remodeling Neurofilaments
  • Cytoskeleton remodeling Reverse signaling by ephrin B
3 Cell Signaling Technology pathways for TUBA1B Gene

SIGNOR curated interactions for TUBA1B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA,IBA 21873635
GO:0000278 mitotic cell cycle IBA 21873635
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA,TAS 12090300
GO:0030705 cytoskeleton-dependent intracellular transport TAS 12090300
genes like me logo Genes that share ontologies with TUBA1B: view

Drugs & Compounds for TUBA1B Gene

(42) Drugs for TUBA1B Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2330
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Experimental Pharma Target 0
Patupilone Experimental, Investigational Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(32) Additional Compounds for TUBA1B Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Noscapine hydrochloride
912-60-7
taxol
Agonist 33069-62-4

(5) Tocris Compounds for TUBA1B Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9

(4) ApexBio Compounds for TUBA1B Gene

Compound Action Cas Number
Docetaxel Microtubulin disassembly inhibitor 114977-28-5
Epothilone A Microtubule stabilizing macrolide 152044-53-6
Epothilone B (EPO906, Patupilone) Microtubule stabilizing macrolide 152044-54-7
MPC 6827 hydrochloride Potent microtubule inhibitor 917369-31-4
genes like me logo Genes that share compounds with TUBA1B: view

Drug Products

Transcripts for TUBA1B Gene

mRNA/cDNA for TUBA1B Gene

1 REFSEQ mRNAs :
33 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBA1B

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA1B Gene

No ASD Table

Relevant External Links for TUBA1B Gene

GeneLoc Exon Structure for
TUBA1B

Expression for TUBA1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUBA1B Gene

Protein differential expression in normal tissues from HIPED for TUBA1B Gene

This gene is overexpressed in Bone (29.6) and Brain (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TUBA1B Gene



Protein tissue co-expression partners for TUBA1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TUBA1B

SOURCE GeneReport for Unigene cluster for TUBA1B Gene:

Hs.524390

Evidence on tissue expression from TISSUES for TUBA1B Gene

  • Nervous system(5)
  • Skin(5)
  • Lung(5)
  • Liver(5)
  • Eye(4.9)
  • Intestine(4.9)
  • Muscle(4.9)
  • Kidney(4.9)
  • Pancreas(4.8)
  • Blood(4.8)
  • Heart(4.6)
  • Stomach(4.6)
  • Bone(4.4)
  • Spleen(3.7)
  • Bone marrow(3.2)
  • Lymph node(3.1)
  • Thyroid gland(2.6)
  • Gall bladder(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with TUBA1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBA1B Gene

Orthologs for TUBA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1B Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia -- 31
  • 100 (a)
ManyToMany
LOC610636 30
  • 85.37 (n)
Oppossum
(Monodelphis domestica)
Mammalia TUBA1B 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia TUBA1B 30 31
  • 99.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TUBA1B 30 31
  • 95.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tuba1b 30 17 31
  • 94.38 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 94 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves TUBAL3 30
  • 81.85 (n)
-- 31
  • 57 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 100 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tuba4a 30
  • 87.21 (n)
Zebrafish
(Danio rerio)
Actinopterygii tuba2 30 31
  • 82.63 (n)
ManyToMany
-- 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.460 30
Worm
(Caenorhabditis elegans)
Secernentea Y19D2B.1 31
  • 82 (a)
OneToMany
tba-9 30
  • 71.99 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7613 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
Species where no ortholog for TUBA1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TUBA1B Gene

ENSEMBL:
Gene Tree for TUBA1B (if available)
TreeFam:
Gene Tree for TUBA1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUBA1B: view image

Paralogs for TUBA1B Gene

(29) SIMAP similar genes for TUBA1B Gene using alignment to 7 proteins:

  • TBA1B_HUMAN
  • F8VRK0_HUMAN
  • F8VU66_HUMAN
  • F8VVB9_HUMAN
  • F8VWV9_HUMAN
  • F8VX09_HUMAN
  • Q8WU19_HUMAN

Pseudogenes.org Pseudogenes for TUBA1B Gene

genes like me logo Genes that share paralogs with TUBA1B: view

Variants for TUBA1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TUBA1B Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
747171 Benign: not provided 49,129,702(-) G/A SYNONYMOUS_VARIANT
768541 Benign: not provided 49,128,795(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TUBA1B Gene

Structural Variations from Database of Genomic Variants (DGV) for TUBA1B Gene

Variant ID Type Subtype PubMed ID
nsv975485 CNV duplication 23825009

Variation tolerance for TUBA1B Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBA1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBA1B Gene

Disorders for TUBA1B Gene

MalaCards: The human disease database

(8) MalaCards diseases for TUBA1B Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TUBA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBA1B Gene

Publications for TUBA1B Gene

  1. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. (PMID: 6646120) Cowan NJ … Cleveland DW (Molecular and cellular biology 1983) 2 3 4
  2. Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of alpha-tubulin. (PMID: 20204303) Gridling M … Krupitza G (Oncology reports 2010) 3 23
  3. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PMID: 19409876) Wei SM … Cai JT (Biochemical and biophysical research communications 2009) 3 23
  4. Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast. (PMID: 19215229) Niu Y … Zhang F (Cancer science 2009) 3 23
  5. alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. (PMID: 18195004) Kawahara K … Masliah E (The Journal of biological chemistry 2008) 3 23

Products for TUBA1B Gene

  • Signalway ELISA kits for TUBA1B
  • Signalway Proteins for TUBA1B

Sources for TUBA1B Gene