Aliases for TUBA1B Gene
External Ids for TUBA1B Gene
Previous GeneCards Identifiers for TUBA1B Gene
GeneCards Summary for TUBA1B Gene
TUBA1B (Tubulin Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include Kenny-Caffey Syndrome and Hypoparathyroidism-Retardation-Dysmorphism Syndrome. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA1A.
UniProtKB/Swiss-Prot Summary for TUBA1B Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).